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The map label for this gene is vanR [H]

Identifier: 226947596

GI number: 226947596

Start: 459197

End: 459895

Strand: Direct

Name: vanR [H]

Synonym: CLM_0433

Alternate gene names: 226947596

Gene position: 459197-459895 (Clockwise)

Preceding gene: 226947595

Following gene: 226947597

Centisome position: 11.05

GC content: 28.47

Gene sequence:

>699_bases
ATGTCAGCAGAAAAAATCCTTATTGTTGATGATGAAAAAGAAATCAGAGATTTAATAGATATATACTTAACCAATGAAGG
TTATATAACTTTAAAGGCATCTAATGGTATAGAGGCATTAGAGCTTTTAAAAACTAATAATGTTCATCTTATAATATTAG
ATATAATGATGCCTAAGATGGATGGTATAGAAGCTTGCATGAAAATAAGAGAAGAAAAAAGTATGCCTATAATAATGCTT
TCAGCTAAGAGTGAAGATATGGATAAAATAATAGGATTAACCACAGGTGCAGATGATTATATAACAAAGCCTTTTAATCC
CTTAGAACTTTTAGCTAGAGTTAAATCTCAGTTGAGAAGATATATAAAGCTTAATAATTCAAATGGAAATGAAAATGAAG
ATATTGTTACTATAGAGGATATAACTATAAATGTAGCAACTCATGAGGTTAAAATTGGAGATCAGCCAGTTAGACTTACA
CCGAGAGAATTTGATATTTTAGAGCTACTGGCTAGAAATAGAGGAGTAGTGTTTAGTATAGAAAAGATATATGAATTAGT
ATGGAAAGAAGAATTTTTAGACTCTAATAATACAGTAATGGTTCATATAAGAAAATTAAGAGAAAAAATAGAACAAAATC
CTAGAAATCCAAGATATATAAAAACAGTTTGGGGAGTTGGGTATAAGGTTGAAAAATAG

Upstream 100 bases:

>100_bases
TTATAAAACAACATGTTTTATTAGACGCAATATTTGCTATAATCTTAGGTGAAGGAATTTACAATATGATAAATTATTAT
GGTTTGGAGATGATTAAGAA

Downstream 100 bases:

>100_bases
AATAAAGAGATTATTTAATAAAATAATGAAACCTTTCAAATATATATATAAATTAATATCTTATAAAGTAAAAAAAAGTT
TAAGATTAGAACTTATATTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSAEKILIVDDEKEIRDLIDIYLTNEGYITLKASNGIEALELLKTNNVHLIILDIMMPKMDGIEACMKIREEKSMPIIML
SAKSEDMDKIIGLTTGADDYITKPFNPLELLARVKSQLRRYIKLNNSNGNENEDIVTIEDITINVATHEVKIGDQPVRLT
PREFDILELLARNRGVVFSIEKIYELVWKEEFLDSNNTVMVHIRKLREKIEQNPRNPRYIKTVWGVGYKVEK

Sequences:

>Translated_232_residues
MSAEKILIVDDEKEIRDLIDIYLTNEGYITLKASNGIEALELLKTNNVHLIILDIMMPKMDGIEACMKIREEKSMPIIML
SAKSEDMDKIIGLTTGADDYITKPFNPLELLARVKSQLRRYIKLNNSNGNENEDIVTIEDITINVATHEVKIGDQPVRLT
PREFDILELLARNRGVVFSIEKIYELVWKEEFLDSNNTVMVHIRKLREKIEQNPRNPRYIKTVWGVGYKVEK
>Mature_231_residues
SAEKILIVDDEKEIRDLIDIYLTNEGYITLKASNGIEALELLKTNNVHLIILDIMMPKMDGIEACMKIREEKSMPIIMLS
AKSEDMDKIIGLTTGADDYITKPFNPLELLARVKSQLRRYIKLNNSNGNENEDIVTIEDITINVATHEVKIGDQPVRLTP
REFDILELLARNRGVVFSIEKIYELVWKEEFLDSNNTVMVHIRKLREKIEQNPRNPRYIKTVWGVGYKVEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=39.1111111111111, Blast_Score=179, Evalue=9e-47,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=35.7142857142857, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=33.9130434782609, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=35.6828193832599, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=35.1111111111111, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.9649122807018, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=30.7359307359307, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=31.3559322033898, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=32.4444444444444, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.0884955752212, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.6943231441048, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=29.3859649122807, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=35.9223300970874, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=31.8181818181818, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26802; Mature: 26670

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEKILIVDDEKEIRDLIDIYLTNEGYITLKASNGIEALELLKTNNVHLIILDIMMPKM
CCCCEEEEEECHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHCCCCEEEEEEEEECCCC
DGIEACMKIREEKSMPIIMLSAKSEDMDKIIGLTTGADDYITKPFNPLELLARVKSQLRR
CHHHHHHHHHHCCCCCEEEEECCCCCHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YIKLNNSNGNENEDIVTIEDITINVATHEVKIGDQPVRLTPREFDILELLARNRGVVFSI
HEEEECCCCCCCCCEEEEEEEEEEEEEEEEEECCCCEEECCCCHHHHHHHHCCCCEEEEH
EKIYELVWKEEFLDSNNTVMVHIRKLREKIEQNPRNPRYIKTVWGVGYKVEK
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCEEECC
>Mature Secondary Structure 
SAEKILIVDDEKEIRDLIDIYLTNEGYITLKASNGIEALELLKTNNVHLIILDIMMPKM
CCCEEEEEECHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHCCCCEEEEEEEEECCCC
DGIEACMKIREEKSMPIIMLSAKSEDMDKIIGLTTGADDYITKPFNPLELLARVKSQLRR
CHHHHHHHHHHCCCCCEEEEECCCCCHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YIKLNNSNGNENEDIVTIEDITINVATHEVKIGDQPVRLTPREFDILELLARNRGVVFSI
HEEEECCCCCCCCCEEEEEEEEEEEEEEEEEECCCCEEECCCCHHHHHHHHCCCCEEEEH
EKIYELVWKEEFLDSNNTVMVHIRKLREKIEQNPRNPRYIKTVWGVGYKVEK
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]