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The map label for this gene is cpx [H]

Identifier: 226947547

GI number: 226947547

Start: 404911

End: 406212

Strand: Direct

Name: cpx [H]

Synonym: CLM_0384

Alternate gene names: 226947547

Gene position: 404911-406212 (Clockwise)

Preceding gene: 226947546

Following gene: 226947548

Centisome position: 9.74

GC content: 33.33

Gene sequence:

>1302_bases
ATGAAAAAGAATGAGACGGATATTCAGTTAATGTATGGGGTTAATGATAAGCCAAAAATATTAATGCAAATTTTATTAGG
ATTGCAGCATATTTTTGCGGCTTTTGGTGGAATAATTGTTGTTCCAATTGTTATTTCAGCAGCCTTAGGCTTTGATGCTA
AAACTTCAACTGCATTAATTAGTAGTGCAATTTTAGCGGCAGGAGTGGCTACTTTCATTCAGTCAAGAGGAATAGGTCCT
ATTGGAGCACATGTTGCCTGTATTATGGGAACTGATTTTACATTTGTTGCACCGGCAATTGCTGTTGGTGGAAAGTTTGG
ATTATCAGGAATTTTTGGAGCGACAATTTTAGGCGCTGGTATAGTAATTATTTTAAGTTTTTTTGTTAAGCCACTAATGA
AATTATTTCCACCTATTGTAACAGGAACAGTTGTGAGCTTAATCGGGTTAACATTATTACCAGTTTCAATAGATTGGGCA
GCAGGAGGTGCAGGATCTGCGAATTATGGAAGTTTAAAAAATATTTCTATTGCTTTATTTATAATGATAGTTACATTATT
ACTAAATCATTATGGAAAGGGATTAGTAAGCAGTGCTTCAATCTTAATAGGTATGGTTGTTGGATATATAATTTGTATTC
CATTAGGAATGGTTAATTTTTCATCAGTAAGCCAAGCTAGTTGGATATCATTACCTAAAATTTTTGGCTATGGCATAACT
TTTAACTTACAGGTTTTATTACCTTTTATTCCTGCATATTTTGTTACTATCATTGGAACCGTTGGATGTCTTAAAGCTAT
TACTGAAGTTTCTGGAATTAAAGAAGATGAAAAGCCTATTACAGCAGGAGTCCTATCTGATGGTGTAGGAAGTATGTTAG
CAGGAGTTTTTGGTGCCTTACCTAATACATCATTTAGTCAAAATATTGGATTAATTCCTCTAACAAAAGTAGCTAGCCGT
TATGTAACAATGATGGCTGGAATACTATTAGTTATTTTAGGATTGTTTCCTAAATTTGCTGCACTAATCAACATAATGCC
ACAGCCGGTACTTGGTGGTGTAGGAATTGTTATGTTTGGAACAGTTGCTGCAGCAGGAATTCAAACTTTAAGTAGTGTAA
AGTTAAATAATAGGAATATGTTAATAATTGCCACATCCATTGGCTTAGGATTAGGTGTTACCTTCCGTCCGGAATTTATT
GCTCAATTACCAGAATCCTTAAAAATGATTTTTTCATCAGGAATTTCAACTGGAACAATTGTAGCTTTATTATTAAATGT
AATATTAAAAGAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTATCTCCTATATAGGTGGATTCTTATTTATGTACCTTAAGATGCTGTATGATAAATAAATTTTTAGAGCATTAATAAAA
TTAGGGAGGAGAGTAGTAAA

Downstream 100 bases:

>100_bases
GGAATTTTACGGGGTGATATAAGTGGAAAAATTACAAAATCGTATTTTACAAGAAGGTCATGCATTATCTGAAACTGTAT
TAAAGGTGGATTCTTTTTTA

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKTSTALISSAILAAGVATFIQSRGIGP
IGAHVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVNFSSVSQASWISLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Sequences:

>Translated_433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKTSTALISSAILAAGVATFIQSRGIGP
IGAHVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVNFSSVSQASWISLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE
>Mature_433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKTSTALISSAILAAGVATFIQSRGIGP
IGAHVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVNFSSVSQASWISLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=468, Percent_Identity=25.6410256410256, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI44680143, Length=472, Percent_Identity=25.8474576271186, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI44680148, Length=500, Percent_Identity=25, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI40316845, Length=500, Percent_Identity=25, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI87082181, Length=411, Percent_Identity=39.9026763990268, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1790087, Length=448, Percent_Identity=35.2678571428571, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=34.6153846153846, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788843, Length=395, Percent_Identity=31.3924050632911, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081818, Length=449, Percent_Identity=28.0623608017817, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17558856, Length=462, Percent_Identity=25.1082251082251, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17541904, Length=451, Percent_Identity=25.0554323725055, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17542262, Length=445, Percent_Identity=24.7191011235955, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71993493, Length=443, Percent_Identity=23.4762979683973, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193206893, Length=458, Percent_Identity=24.235807860262, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17542260, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=434, Percent_Identity=25.1152073732719, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44934; Mature: 44934

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKTSTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SSAILAAGVATFIQSRGIGPIGAHVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGAGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVNFSSVSQASWISLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC
>Mature Secondary Structure
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKTSTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SSAILAAGVATFIQSRGIGPIGAHVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGAGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVNFSSVSQASWISLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]