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The map label for this gene is ddc [H]

Identifier: 226947462

GI number: 226947462

Start: 280537

End: 281961

Strand: Direct

Name: ddc [H]

Synonym: CLM_0291

Alternate gene names: 226947462

Gene position: 280537-281961 (Clockwise)

Preceding gene: 226947461

Following gene: 226947463

Centisome position: 6.75

GC content: 33.12

Gene sequence:

>1425_bases
ATGGATATAAATTTAAAGAATGATTTAGAGAATATGGATATTTTATTAGAAAAAATAACAATTAACGCCTTTGATTTTCT
AAAAGATATTAATGAAATAGCGACTTTCACAAAAAGTACAAATGCTTATACACTTTCTCAATTAAACAAAGATGGGTTAG
GTGGAGAAAAAACATTAGAAGAGTTTATGCAAAGATTTTATAATGGAATAGTTTCATGTGCAGGATCAAAGTATTTTGGC
TTTGTAACTGGAGGTACAACTCCAGCAGCTTTGATGGGCGATTGGTTAGTAAGTACATTTGATCAAAATGCCACAGGTAG
AGATAATTCCAGTGCAGCAAAGCTTGAGGAAGAAACCATAAATTTATTAAAGCAGCTTTTAGTATTGCCGGAAACATATT
CGGGAACCTTTGTAACCGGAGCTACTATGGCTAACTTTGTGGGCTTAGCAATTGGAAGGCAGTGGCTAGCTAATGAATTA
GGCGTTAACATAGCTATAGATGGTCTGTATTCTATTCCGCCAATAAGAATTGTAAGTTCTACTCCTCATTCAAGTATTTC
AAAAGCTATGTCTATGCTAGGCATGGGAAGAAAAAATATGCATTATATTCCTACGATTGATGGGAGAGAGGCTATAGATG
TTGAAGCATTAGAAAGTTATTTAAAAAAGTTGAATGGAGAACCATGTATTGTTGTAGCAAATGCAGGAACAGTAAATACT
GTTGATTTTGATGATTTAAAACAAATTGGAGAATTAAAGAAAAAATATAATTTTTTTCTCCATGTAGATGGAGCTTTTGG
AGGCTTTGCTTCTTGTTCAATAAAGTACAAAAAACTTGTAGAAGGAATTGAAGCAGCAGATTCTATTACTATAGATGCAC
ATAAGTGGCTAAATGTTCCTTATGATAGTGCAATACAGTTCACTAAACATCCTAAACTTCAGCTTCAAGTTTTTCAAAAC
AACGCAGTATATCTAGGCGAGCTTTCAGATAAGCCTGATTTTGTTCATTTAACTCCAGAAAATTCAAGAAGGTTAAGGGC
TCTTCCTGCATGGTTTACCCTAAAGGCATATGGCCAAAATGGATATCAGGAGATAATTGAGAGAAACTGTAATCTAGCAC
AATTGTTAAGTAAAAAAATTGATGAATCTAAAAATTTTAGGTTACTGTCAACTACTAGATTAAATGTAGTTTGCTTTACC
ATTAATCTTGAGAATGGTAATGTTAAATTAGAGCAAATACAGCAATTTTTAAATTTGGTTAATAAGGATGGCAGAGCATT
CTTTACTCAAACAGTATATAAAGGAATAGCAGGAATAAGGGCAGCTATAAGCAATTGGAGGACGGAGGAAAAAGATATTG
AAATCGCATGGGAAGTATTGAATGAGGCATATAATTCCTATTATGAAACAATAACAGCAGATTGA

Upstream 100 bases:

>100_bases
AGGGATCATCTTCAACTATTAAGATTGATTATATATAATATGATACATATACTATATCACAATATTAAGTTACAAAGAAA
ACCATGAAAGGAGTATATCT

Downstream 100 bases:

>100_bases
TTTAGAAAAGTATTTTACAAGTTTTGAAACAGGTAAAAATTTAAAGAAACTTAAGGTTTTTCTAGTGTTAAGCACTATTT
TTAGATTTTTATATGTATTA

Product: putative pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDINLKNDLENMDILLEKITINAFDFLKDINEIATFTKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYNGIVSCAGSKYFG
FVTGGTTPAALMGDWLVSTFDQNATGRDNSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSISKAMSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKKKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAIQFTKHPKLQLQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFRLLSTTRLNVVCFT
INLENGNVKLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNEAYNSYYETITAD

Sequences:

>Translated_474_residues
MDINLKNDLENMDILLEKITINAFDFLKDINEIATFTKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYNGIVSCAGSKYFG
FVTGGTTPAALMGDWLVSTFDQNATGRDNSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSISKAMSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKKKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAIQFTKHPKLQLQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFRLLSTTRLNVVCFT
INLENGNVKLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNEAYNSYYETITAD
>Mature_474_residues
MDINLKNDLENMDILLEKITINAFDFLKDINEIATFTKSTNAYTLSQLNKDGLGGEKTLEEFMQRFYNGIVSCAGSKYFG
FVTGGTTPAALMGDWLVSTFDQNATGRDNSSAAKLEEETINLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANEL
GVNIAIDGLYSIPPIRIVSSTPHSSISKAMSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
VDFDDLKQIGELKKKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVPYDSAIQFTKHPKLQLQVFQN
NAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQNGYQEIIERNCNLAQLLSKKIDESKNFRLLSTTRLNVVCFT
INLENGNVKLEQIQQFLNLVNKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNEAYNSYYETITAD

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=417, Percent_Identity=24.4604316546763, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI132814448, Length=417, Percent_Identity=24.4604316546763, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI92110055, Length=416, Percent_Identity=24.7596153846154, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI197383062, Length=274, Percent_Identity=30.2919708029197, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI197276620, Length=402, Percent_Identity=24.1293532338308, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503875, Length=402, Percent_Identity=24.1293532338308, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI194294551, Length=339, Percent_Identity=25.9587020648968, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI58331246, Length=328, Percent_Identity=26.5243902439024, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI190341074, Length=252, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17534819, Length=427, Percent_Identity=24.3559718969555, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17534817, Length=427, Percent_Identity=24.3559718969555, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71993062, Length=330, Percent_Identity=25.1515151515152, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71993058, Length=330, Percent_Identity=25.4545454545455, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17555682, Length=330, Percent_Identity=25.1515151515152, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71981217, Length=294, Percent_Identity=25.8503401360544, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71981211, Length=294, Percent_Identity=25.8503401360544, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17551992, Length=293, Percent_Identity=25.5972696245734, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI133931025, Length=428, Percent_Identity=21.4953271028037, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17543922, Length=297, Percent_Identity=23.2323232323232, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320500, Length=259, Percent_Identity=23.1660231660232, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221476190, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585143, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585139, Length=292, Percent_Identity=28.4246575342466, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24652373, Length=477, Percent_Identity=26.2054507337526, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136594, Length=387, Percent_Identity=27.390180878553, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28573972, Length=415, Percent_Identity=26.5060240963855, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21356415, Length=352, Percent_Identity=25.8522727272727, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24586044, Length=470, Percent_Identity=22.5531914893617, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17136190, Length=235, Percent_Identity=25.531914893617, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585135, Length=235, Percent_Identity=25.531914893617, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24657193, Length=330, Percent_Identity=23.9393939393939, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657185, Length=330, Percent_Identity=23.9393939393939, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657188, Length=330, Percent_Identity=23.9393939393939, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52933; Mature: 52933

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINLKNDLENMDILLEKITINAFDFLKDINEIATFTKSTNAYTLSQLNKDGLGGEKTLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCHHHHH
EFMQRFYNGIVSCAGSKYFGFVTGGTTPAALMGDWLVSTFDQNATGRDNSSAAKLEEETI
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
NLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANELGVNIAIDGLYSIPPIRIVSS
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCEEEEEC
TPHSSISKAMSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
CCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEC
VDFDDLKQIGELKKKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVP
CCHHHHHHHHHHHHHCEEEEEECCCCCCCHHCCEEHHHHHHHHHHCCCEEEEHHHHCCCC
YDSAIQFTKHPKLQLQVFQNNAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQN
HHHHEEECCCCCEEEEEEECCCEEEEECCCCCCEEEECCCCCCCEEECCCEEEEEECCCC
GYQEIIERNCNLAQLLSKKIDESKNFRLLSTTRLNVVCFTINLENGNVKLEQIQQFLNLV
HHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEEEEEEEEECCCCEEHHHHHHHHHHH
NKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNEAYNSYYETITAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDINLKNDLENMDILLEKITINAFDFLKDINEIATFTKSTNAYTLSQLNKDGLGGEKTLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCHHHHH
EFMQRFYNGIVSCAGSKYFGFVTGGTTPAALMGDWLVSTFDQNATGRDNSSAAKLEEETI
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
NLLKQLLVLPETYSGTFVTGATMANFVGLAIGRQWLANELGVNIAIDGLYSIPPIRIVSS
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCEEEEEC
TPHSSISKAMSMLGMGRKNMHYIPTIDGREAIDVEALESYLKKLNGEPCIVVANAGTVNT
CCHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEC
VDFDDLKQIGELKKKYNFFLHVDGAFGGFASCSIKYKKLVEGIEAADSITIDAHKWLNVP
CCHHHHHHHHHHHHHCEEEEEECCCCCCCHHCCEEHHHHHHHHHHCCCEEEEHHHHCCCC
YDSAIQFTKHPKLQLQVFQNNAVYLGELSDKPDFVHLTPENSRRLRALPAWFTLKAYGQN
HHHHEEECCCCCEEEEEEECCCEEEEECCCCCCEEEECCCCCCCEEECCCEEEEEECCCC
GYQEIIERNCNLAQLLSKKIDESKNFRLLSTTRLNVVCFTINLENGNVKLEQIQQFLNLV
HHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEEEEEEEEEEECCCCEEHHHHHHHHHHH
NKDGRAFFTQTVYKGIAGIRAAISNWRTEEKDIEIAWEVLNEAYNSYYETITAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]