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The map label for this gene is rnr [H]

Identifier: 226947453

GI number: 226947453

Start: 269120

End: 271297

Strand: Direct

Name: rnr [H]

Synonym: CLM_0282

Alternate gene names: 226947453

Gene position: 269120-271297 (Clockwise)

Preceding gene: 226947452

Following gene: 226947454

Centisome position: 6.48

GC content: 29.34

Gene sequence:

>2178_bases
ATGAATATAAGAGAAACAATATTAGCTTTTATGGAAGAACAGGCATATAAACCTATGAATATAAAAGAATTAAAGCAGGT
GTTTGGGGTAACTAAGCATGAATATAAAGATTTTGAGAAAATGTTAAGGGATATGGAAAAGGACGGACAAATAGTTAAAA
CAAGAACAGAACACTATGGCATACCGGCCAGAATGGGATTAGTTCTAGGAAAGCTTCAAGGACATCAAAAAGGTTATGGA
TTTGTTATACCAGAAGAAGAAAGAGAAGATATTTTTATACCAGCATCTAGTATGAATGGAGCTATGCATACTGATAGAGT
ATTAGCTAAAATTACTAAAGAATCAGCTAATGGAAAAAGATGCGAAGGTGAAATAATAAGAATATTAGAAAGAGGCAATA
AAACAGTCATAGGCATATACGAAGATAGTAAAAACTTTGGTTTTGTAGTTTCCGATGATAAAAAGATATATCAAGACATA
TTCATACCAAAGGGAGATAAAAATGGAGCAAAAACAGGTCAAGTAGTTATAGCAGAGATTGTAACTTATCCAGAAAAGAG
AAGAAATCCAGAAGGAAGAATTATAGAAATATTAGGATATAAAGAAGATAAAGGTATAGATATATTAACTATAATTAAGA
AAAATAAATTACCTGAAGAATTTCCTCCAAAGGTACAAAGTTACGCTGATAACATATCAGAAGCAATTCCAGAGGAAGAA
TATAAAAGAAGAGAAGATTTAAGAGATCTAACTATTGTTACTATAGATGGAGAAGATGCTAAGGATTTAGATGATGCCAT
ATCTTTAGAGAAATTATCTAACGGAAACTATTATTTAGGAGTACATATAGCAGATGTATCTCACTATGTAAAAGAGAAAA
ATCCACTAGATAAAGAAGCTTTAAAAAGAGCAACTTCAGTATATCTTATAGATAGGGTAATACCAATGTTACCTAAAAAA
CTTTCTAATGGAATATGTAGTTTGAATCCTAAAATTGATAGATTAACCTTAAGTTGTTTTATGGAAATAGATAAGAATGG
TAAGGTAGTAGATCATAGAGTGGTAGAAAGTATAATAAAAAGCACTGAAAGAATGACCTATACAGATGTGACTAAAATAC
TAAGAGATGAAGATGAGGAAACTATAAATAAATATAGCAATTTAGTGGATTATTTCAAACTTATGGAGGAACTTTGCAAA
ATACTTTACAAGAAAAGACTAAAAAGAGGAGCTATAGACTTCGATTTTGAGGAATGTAAAATAATATTAGATGAAAAGGG
TAAGCCAATAGAGATAAAACCTTATGAAAGAGCTATAGCAAACAGAATAATAGAGGAATTTATGCTTGTTTGTAATGAAA
CTATAGCAGAGCATATGTTCTGGTCTAATTTACCTTTTGTATATAGAATACATGAAGATCCAGATGAAGAAAAATTAATG
CATTTTAACGAATTTGTTCATAATCTAGGATATGTTATAAGATGGAATAATGATATTCATCCAAAATCATTGCAAACTAT
TATAGAAAAAGTAAAAGGGGAAAAAGAAGAAACTGTAGTTAGCACATTGCTTTTACGATCATTAAAACAAGCAAGATACT
CTCCAGAATGTATAGGACACTTTGGATTAGCTGCAAGATATTACTGTCACTTTACTTCACCAATAAGAAGATATCCAGAC
CTTATCATACACAGAATAATAAAAGAATATATAAATGGACAGATTGATGATAAAAGAGCTACAAGGCTTACAACAGAAGT
AGAATATGCTTCTAAACAATCTTCAGAAATGGAAAGAGTAGCTCAAGAAGCTGAAAGAGAAGTAGATGATTTAAAGAAAG
CAGAATATATGAGTGAAAGAATAGGGGAAGAATACGAAGGAATAATATCTTCAGTAACTAATTTTGGAATGTTTGTAGAA
CTACCAAATACAATAGAAGGATTAGTTCATATAAGTACACTATCTGACGATTACTATATATATGATGAAAGACGATTAAG
TTTAATTGGAGAAGCTAGCAAAAATATATATAGATTAGGAGATACAGTAAAAATTAAAGTTTCAAAAGTAGATTTATTTA
GTCATGAAATATATTTTGATATTATAAAAGATGATGAAGAAGATAAAGAAGAGGTTGAATTTATAGAAGAAACAGAAAAG
TATAATACCAATTTATAG

Upstream 100 bases:

>100_bases
TATTATATAAATAACATAATAAAAATCATTGATTTTATTATAAAAAATAGATTAATGATTAGAATATATGTTAGGAACCT
TTAATTATAGGAGGGATTTT

Downstream 100 bases:

>100_bases
GTTAAAAATTATTTAAGAGAAACTCAGTTTAAAGTTAATGCTGAGTTTCTCTTATAAGTTTTAAAAGATATATATTATAT
TTTATAGATACAATTTAATT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MNIRETILAFMEEQAYKPMNIKELKQVFGVTKHEYKDFEKMLRDMEKDGQIVKTRTEHYGIPARMGLVLGKLQGHQKGYG
FVIPEEEREDIFIPASSMNGAMHTDRVLAKITKESANGKRCEGEIIRILERGNKTVIGIYEDSKNFGFVVSDDKKIYQDI
FIPKGDKNGAKTGQVVIAEIVTYPEKRRNPEGRIIEILGYKEDKGIDILTIIKKNKLPEEFPPKVQSYADNISEAIPEEE
YKRREDLRDLTIVTIDGEDAKDLDDAISLEKLSNGNYYLGVHIADVSHYVKEKNPLDKEALKRATSVYLIDRVIPMLPKK
LSNGICSLNPKIDRLTLSCFMEIDKNGKVVDHRVVESIIKSTERMTYTDVTKILRDEDEETINKYSNLVDYFKLMEELCK
ILYKKRLKRGAIDFDFEECKIILDEKGKPIEIKPYERAIANRIIEEFMLVCNETIAEHMFWSNLPFVYRIHEDPDEEKLM
HFNEFVHNLGYVIRWNNDIHPKSLQTIIEKVKGEKEETVVSTLLLRSLKQARYSPECIGHFGLAARYYCHFTSPIRRYPD
LIIHRIIKEYINGQIDDKRATRLTTEVEYASKQSSEMERVAQEAEREVDDLKKAEYMSERIGEEYEGIISSVTNFGMFVE
LPNTIEGLVHISTLSDDYYIYDERRLSLIGEASKNIYRLGDTVKIKVSKVDLFSHEIYFDIIKDDEEDKEEVEFIEETEK
YNTNL

Sequences:

>Translated_725_residues
MNIRETILAFMEEQAYKPMNIKELKQVFGVTKHEYKDFEKMLRDMEKDGQIVKTRTEHYGIPARMGLVLGKLQGHQKGYG
FVIPEEEREDIFIPASSMNGAMHTDRVLAKITKESANGKRCEGEIIRILERGNKTVIGIYEDSKNFGFVVSDDKKIYQDI
FIPKGDKNGAKTGQVVIAEIVTYPEKRRNPEGRIIEILGYKEDKGIDILTIIKKNKLPEEFPPKVQSYADNISEAIPEEE
YKRREDLRDLTIVTIDGEDAKDLDDAISLEKLSNGNYYLGVHIADVSHYVKEKNPLDKEALKRATSVYLIDRVIPMLPKK
LSNGICSLNPKIDRLTLSCFMEIDKNGKVVDHRVVESIIKSTERMTYTDVTKILRDEDEETINKYSNLVDYFKLMEELCK
ILYKKRLKRGAIDFDFEECKIILDEKGKPIEIKPYERAIANRIIEEFMLVCNETIAEHMFWSNLPFVYRIHEDPDEEKLM
HFNEFVHNLGYVIRWNNDIHPKSLQTIIEKVKGEKEETVVSTLLLRSLKQARYSPECIGHFGLAARYYCHFTSPIRRYPD
LIIHRIIKEYINGQIDDKRATRLTTEVEYASKQSSEMERVAQEAEREVDDLKKAEYMSERIGEEYEGIISSVTNFGMFVE
LPNTIEGLVHISTLSDDYYIYDERRLSLIGEASKNIYRLGDTVKIKVSKVDLFSHEIYFDIIKDDEEDKEEVEFIEETEK
YNTNL
>Mature_725_residues
MNIRETILAFMEEQAYKPMNIKELKQVFGVTKHEYKDFEKMLRDMEKDGQIVKTRTEHYGIPARMGLVLGKLQGHQKGYG
FVIPEEEREDIFIPASSMNGAMHTDRVLAKITKESANGKRCEGEIIRILERGNKTVIGIYEDSKNFGFVVSDDKKIYQDI
FIPKGDKNGAKTGQVVIAEIVTYPEKRRNPEGRIIEILGYKEDKGIDILTIIKKNKLPEEFPPKVQSYADNISEAIPEEE
YKRREDLRDLTIVTIDGEDAKDLDDAISLEKLSNGNYYLGVHIADVSHYVKEKNPLDKEALKRATSVYLIDRVIPMLPKK
LSNGICSLNPKIDRLTLSCFMEIDKNGKVVDHRVVESIIKSTERMTYTDVTKILRDEDEETINKYSNLVDYFKLMEELCK
ILYKKRLKRGAIDFDFEECKIILDEKGKPIEIKPYERAIANRIIEEFMLVCNETIAEHMFWSNLPFVYRIHEDPDEEKLM
HFNEFVHNLGYVIRWNNDIHPKSLQTIIEKVKGEKEETVVSTLLLRSLKQARYSPECIGHFGLAARYYCHFTSPIRRYPD
LIIHRIIKEYINGQIDDKRATRLTTEVEYASKQSSEMERVAQEAEREVDDLKKAEYMSERIGEEYEGIISSVTNFGMFVE
LPNTIEGLVHISTLSDDYYIYDERRLSLIGEASKNIYRLGDTVKIKVSKVDLFSHEIYFDIIKDDEEDKEEVEFIEETEK
YNTNL

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=600, Percent_Identity=28.1666666666667, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI190014623, Length=600, Percent_Identity=28.1666666666667, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI134288890, Length=370, Percent_Identity=32.4324324324324, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI219521928, Length=585, Percent_Identity=25.982905982906, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI19115966, Length=585, Percent_Identity=25.982905982906, Blast_Score=160, Evalue=6e-39,
Organism=Homo sapiens, GI156105695, Length=444, Percent_Identity=23.4234234234234, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI156105693, Length=213, Percent_Identity=28.169014084507, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI87082383, Length=711, Percent_Identity=38.3966244725738, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI1787542, Length=648, Percent_Identity=26.5432098765432, Blast_Score=178, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI212645896, Length=496, Percent_Identity=28.0241935483871, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17553506, Length=533, Percent_Identity=27.3921200750469, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=614, Percent_Identity=27.3615635179153, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=446, Percent_Identity=24.6636771300448, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323943, Length=358, Percent_Identity=25.6983240223464, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24649634, Length=549, Percent_Identity=30.4189435336976, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI19922976, Length=411, Percent_Identity=31.6301703163017, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24654597, Length=411, Percent_Identity=31.6301703163017, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24654592, Length=411, Percent_Identity=31.6301703163017, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84298; Mature: 84298

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRETILAFMEEQAYKPMNIKELKQVFGVTKHEYKDFEKMLRDMEKDGQIVKTRTEHYG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
IPARMGLVLGKLQGHQKGYGFVIPEEEREDIFIPASSMNGAMHTDRVLAKITKESANGKR
CCHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
CEGEIIRILERGNKTVIGIYEDSKNFGFVVSDDKKIYQDIFIPKGDKNGAKTGQVVIAEI
CHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
VTYPEKRRNPEGRIIEILGYKEDKGIDILTIIKKNKLPEEFPPKVQSYADNISEAIPEEE
HHCCHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCHHH
YKRREDLRDLTIVTIDGEDAKDLDDAISLEKLSNGNYYLGVHIADVSHYVKEKNPLDKEA
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHCCCCCCHHH
LKRATSVYLIDRVIPMLPKKLSNGICSLNPKIDRLTLSCFMEIDKNGKVVDHRVVESIIK
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHEEEEHHEEECCCCCCHHHHHHHHHHH
STERMTYTDVTKILRDEDEETINKYSNLVDYFKLMEELCKILYKKRLKRGAIDFDFEECK
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHE
IILDEKGKPIEIKPYERAIANRIIEEFMLVCNETIAEHMFWSNLPFVYRIHEDPDEEKLM
EEECCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
HFNEFVHNLGYVIRWNNDIHPKSLQTIIEKVKGEKEETVVSTLLLRSLKQARYSPECIGH
HHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
FGLAARYYCHFTSPIRRYPDLIIHRIIKEYINGQIDDKRATRLTTEVEYASKQSSEMERV
HHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQEAEREVDDLKKAEYMSERIGEEYEGIISSVTNFGMFVELPNTIEGLVHISTLSDDYYI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEEEEECCCEEE
YDERRLSLIGEASKNIYRLGDTVKIKVSKVDLFSHEIYFDIIKDDEEDKEEVEFIEETEK
ECCHHHHHHHHHCCCCEECCCEEEEEEEEEEHHHHHEEEEEECCCCCCHHHHHHHHHHHH
YNTNL
HCCCC
>Mature Secondary Structure
MNIRETILAFMEEQAYKPMNIKELKQVFGVTKHEYKDFEKMLRDMEKDGQIVKTRTEHYG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
IPARMGLVLGKLQGHQKGYGFVIPEEEREDIFIPASSMNGAMHTDRVLAKITKESANGKR
CCHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
CEGEIIRILERGNKTVIGIYEDSKNFGFVVSDDKKIYQDIFIPKGDKNGAKTGQVVIAEI
CHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
VTYPEKRRNPEGRIIEILGYKEDKGIDILTIIKKNKLPEEFPPKVQSYADNISEAIPEEE
HHCCHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCHHH
YKRREDLRDLTIVTIDGEDAKDLDDAISLEKLSNGNYYLGVHIADVSHYVKEKNPLDKEA
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHCCCCCCHHH
LKRATSVYLIDRVIPMLPKKLSNGICSLNPKIDRLTLSCFMEIDKNGKVVDHRVVESIIK
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHEEEEHHEEECCCCCCHHHHHHHHHHH
STERMTYTDVTKILRDEDEETINKYSNLVDYFKLMEELCKILYKKRLKRGAIDFDFEECK
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHE
IILDEKGKPIEIKPYERAIANRIIEEFMLVCNETIAEHMFWSNLPFVYRIHEDPDEEKLM
EEECCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
HFNEFVHNLGYVIRWNNDIHPKSLQTIIEKVKGEKEETVVSTLLLRSLKQARYSPECIGH
HHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
FGLAARYYCHFTSPIRRYPDLIIHRIIKEYINGQIDDKRATRLTTEVEYASKQSSEMERV
HHHHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQEAEREVDDLKKAEYMSERIGEEYEGIISSVTNFGMFVELPNTIEGLVHISTLSDDYYI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEEEEECCCEEE
YDERRLSLIGEASKNIYRLGDTVKIKVSKVDLFSHEIYFDIIKDDEEDKEEVEFIEETEK
ECCHHHHHHHHHCCCCEECCCEEEEEEEEEEHHHHHEEEEEECCCCCCHHHHHHHHHHHH
YNTNL
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]