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The map label for this gene is atpA

Identifier: 226947378

GI number: 226947378

Start: 182386

End: 183900

Strand: Direct

Name: atpA

Synonym: CLM_0198

Alternate gene names: 226947378

Gene position: 182386-183900 (Clockwise)

Preceding gene: 226947377

Following gene: 226947379

Centisome position: 4.39

GC content: 32.87

Gene sequence:

>1515_bases
ATGAATATAAAGCCAGAAGAAATAACATCAATAATAAGGCAGCAAATAGAAAATTTTAATACTAATATAGAAACTATAGA
TTCTGGAACAATAATTCAGATAGGAGATGGAATCGCTAGGGTTTATGGATTAGAAGATTGCATGGAAGGAGAACTTATAG
AATTCCCAAATGATGTTTATGGAATGGCATTAAACTTAGAACAAGATAATGTAGGCTGTGTTTTATTAGGATCTGAAGAA
GGTATAAAAGAAGGAAATGTAGTAAAAAGAACTAAAAAGGTAGTTGAAGTACCTGTAGGAGAAGCTCTAGTAGGAAGGGT
AGTAAATTCTTTAGGTATGCCTATAGATGGGAAAGGACCAGTCTTAACTACTGAAACTAGAGACGTTGAAGTGCCAGCAC
CTGGAGTTATAGATAGACAGTCTGTAAAAGAGCCATTACAAACAGGAATAAAAGCTATAGATTCTATGATACCTATAGGA
AAAGGACAAAGAGAACTAATTATAGGTGATAGACAAACAGGAAAAACAGCTATAGCAATGGATACCATACTTAATCAAAA
GGGAAAAGATGTAATATGTATATATGTTGCTATAGGACAAAAGCAATCTACAGTAGCACATATAGTTAATGACTTAACTA
AAATGGGAGCTATGGATTATACTATAGTGGTTTCATCTACAGCTTCAGATTCAGCGCCATTGCAATATCTAGCACCTTAT
GCTGGATGTAGCATGGGTGAGTACTTTATGCATAAAGGAAAAGATGTTTTAATAGTATATGATGACTTATCTAAGCATGC
AGTAGCTTATAGAACAATGTCTCTATTACTTAGAAGACCGCCAGGAAGAGAAGCTTATCCAGGAGATGTATTTTATTTAC
ATTCAAGATTACTAGAAAGATCTGCTAGATTGTCAGAGAAGCTAGGTGGAGGTTCATTAACTGCTTTACCTATAGTAGAA
ACTTTAGCAGGAGATGTCACTGCATATATACCAACTAATGTTATATCAATAACAGATGGTCAGATATTCTTAGAATCGGA
ATTATTTAATGCAGGACAAAGACCAGCAGTTAACGCAGGAATATCAGTATCAAGAGTAGGTGGGAATGCTCAAATTAAAG
CTATGAAACAAGTAGCTGGTACATTAAGATTAGAGCTAGCGCAATATAGAGAATTAGCTGCTTTTTCACAGTTTGGATCT
GATTTAGACAAAGAATCCGTGAAAAGGCTAGAAAAGGGTAAAAGGTTAGTTGAAATATTAAAACAACCTCAGTATAGCCC
TATGCCTGTGGAAAAAGAAATAATAATTCTTTATGCAGCAGTTAGTAATCATCTTATAGATATACCTGTAAATAAGATAA
AAGAGTTTGAAAAAGAACTATTTAATTATATTGATACTCATTATAGAGATATAGGAAAAGACATATTAGAACATAAACAA
TTAACTGATGAGCTTAAAAGCAAGCTAGATAAGGCTATAAATGATTTTAAAAATGTATTTTTATCAGAGATTTAA

Upstream 100 bases:

>100_bases
GTATATGTAAGAGTTGGAGATGACGTTTTAGACGGTACTCTAAGTACAAGGTTAAAAGACATAAAAAAAATGATGCTCAA
AAGAGAATAGAGGTGAGATT

Downstream 100 bases:

>100_bases
TATCTCTGAAGGAGGTAAAATATGGCAGGCGCAGGGCTTATCGGAATAAGAAGAAGAATAAAATCTGTAACCAATATAAG
GAAAATAACAAAAGCTATGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVYGMALNLEQDNVGCVLLGSEE
GIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGPVLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIG
KGQRELIIGDRQTGKTAIAMDTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPY
AGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLERSARLSEKLGGGSLTALPIVE
TLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAGISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGS
DLDKESVKRLEKGKRLVEILKQPQYSPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQ
LTDELKSKLDKAINDFKNVFLSEI

Sequences:

>Translated_504_residues
MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVYGMALNLEQDNVGCVLLGSEE
GIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGPVLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIG
KGQRELIIGDRQTGKTAIAMDTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPY
AGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLERSARLSEKLGGGSLTALPIVE
TLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAGISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGS
DLDKESVKRLEKGKRLVEILKQPQYSPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQ
LTDELKSKLDKAINDFKNVFLSEI
>Mature_504_residues
MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVYGMALNLEQDNVGCVLLGSEE
GIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGPVLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIG
KGQRELIIGDRQTGKTAIAMDTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPY
AGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLERSARLSEKLGGGSLTALPIVE
TLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAGISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGS
DLDKESVKRLEKGKRLVEILKQPQYSPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQ
LTDELKSKLDKAINDFKNVFLSEI

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=502, Percent_Identity=58.9641434262948, Blast_Score=613, Evalue=1e-175,
Organism=Homo sapiens, GI4757810, Length=502, Percent_Identity=58.9641434262948, Blast_Score=613, Evalue=1e-175,
Organism=Homo sapiens, GI19913428, Length=294, Percent_Identity=29.9319727891156, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI19913426, Length=294, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI32189394, Length=316, Percent_Identity=25, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI19913424, Length=248, Percent_Identity=27.4193548387097, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790172, Length=508, Percent_Identity=57.4803149606299, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1790170, Length=408, Percent_Identity=26.4705882352941, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788251, Length=291, Percent_Identity=29.553264604811, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=502, Percent_Identity=58.9641434262948, Blast_Score=616, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71988080, Length=502, Percent_Identity=58.9641434262948, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71988074, Length=502, Percent_Identity=55.3784860557769, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17510931, Length=291, Percent_Identity=28.5223367697594, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17570191, Length=323, Percent_Identity=27.5541795665635, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=319, Percent_Identity=24.4514106583072, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=68, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=74, Percent_Identity=41.8918918918919, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=505, Percent_Identity=56.8316831683168, Blast_Score=601, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319603, Length=325, Percent_Identity=28, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=375, Percent_Identity=24.2666666666667, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=58.8118811881188, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=28.1967213114754, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=28.1967213114754, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=28.1967213114754, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24638766, Length=319, Percent_Identity=26.0188087774295, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574560, Length=426, Percent_Identity=26.2910798122066, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583992, Length=255, Percent_Identity=27.0588235294118, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129479, Length=247, Percent_Identity=26.7206477732794, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_CLOB1 (A7FQH7)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382561.1
- ProteinModelPortal:   A7FQH7
- SMR:   A7FQH7
- STRING:   A7FQH7
- GeneID:   5395625
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0190
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   CBOT441770:CLB_0190-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55427; Mature: 55427

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVY
CCCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHCHHHHHCCCCCCCCCCCE
GMALNLEQDNVGCVLLGSEEGIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGP
EEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
VLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIGKGQRELIIGDRQTGKTAIAM
EEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCCC
AGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLER
CCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SARLSEKLGGGSLTALPIVETLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAG
HHHHHHHCCCCCEEHHHHHHHHHCCEEEEECCCEEEEECCCEEEEHHHHCCCCCCCCCCC
ISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGSDLDKESVKRLEKGKRLVEIL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KQPQYSPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQ
HCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDELKSKLDKAINDFKNVFLSEI
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVY
CCCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHCHHHHHCCCCCCCCCCCE
GMALNLEQDNVGCVLLGSEEGIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGP
EEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
VLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIGKGQRELIIGDRQTGKTAIAM
EEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCCC
AGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLER
CCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
SARLSEKLGGGSLTALPIVETLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAG
HHHHHHHCCCCCEEHHHHHHHHHCCEEEEECCCEEEEECCCEEEEHHHHCCCCCCCCCCC
ISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGSDLDKESVKRLEKGKRLVEIL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KQPQYSPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQ
HCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDELKSKLDKAINDFKNVFLSEI
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA