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The map label for this gene is dnaX

Identifier: 226225256

GI number: 226225256

Start: 2748459

End: 2750198

Strand: Reverse

Name: dnaX

Synonym: Lm4b_02678

Alternate gene names: 226225256

Gene position: 2750198-2748459 (Counterclockwise)

Preceding gene: 226225257

Following gene: 226225255

Centisome position: 94.42

GC content: 43.51

Gene sequence:

>1740_bases
ATGGCGTATCAGGCTTTGTATCGGGTTTTTCGGCCGCAGTCGTTTCAGGATGTTGTTGGACAGGAACATGTGACGAAAAC
GCTTAAAAATGCCATTGTGCAAAATAAAACTTCGCACGCTTATTTATTTTCTGGACCTCGGGGGACGGGGAAAACTAGTG
CGGCGAAAATTTTTGCGAAGGCGATTAACTGTGAACACGGCCATGACGGGGAGCCTTGCAATGAATGTGAGATTTGTAAA
GGTACGACGGACGGTTCTATACCAGATGTTCTTGAAATCGATGCTGCCAGTAATAACGGGGTTGAAGAAATTCGAGATAT
CCGGGAAAAAGTAAAATATGCGCCAACTGTGGCGAAATATAAAGTATATATTATCGATGAAGTGCATATGTTGTCGACGG
GAGCGTTTAATGCGCTACTAAAAACGCTGGAAGAACCGCCGAAACATGTCATTTTTATTTTGGCAACAACAGAACCGCAT
AAGTTACCGCTAACGATTATTTCGCGGGTACAACGGTTTGATTTTAAACGAATCACGACACAAGATATTATTGGTCGTTT
GAAATTTATTTTGGAAGAAGAAAAAATCCCTTATGACGAAAAAGCGTTGATGATTGTTGCGCGTGCGGCTGAAGGCGGGA
TGCGTGATGCGCTTAGCTTGCTCGATCAAGTTATTTCCTACGGATCAGAAGAAGTTACCGTGGATGATGCGCTCGAAATT
ACTGGATCTGTTGCGCAAAACTTGCTGACAAAACTAGTAAGTGCAGCGTTTGACGGTGATGCGGCGGAAGCTATTTCAAC
GCTGACAGCACTGCTAGCAGAAGGAAAAGACCCAGTTCGCTTAGTGGAAGATTTACTCGTATTCTTTAGAGATGTGCTGC
TGTATCAAAAAGCGCCGAATCTGGAAGAAACACTGGAACGAGCTTTGATTGATGATGATTTTGTTGCTTTGGCAAAACGA
GCAGATTCACTTAAAGTGTATGAGTTCGTGAAAATTTTAAATACAGCTCAGCAACAAATGCGTTTCTCGAATCATCCGGG
TATTTATGTGGAAGTGGCGCTTATTCAGTTAACTCAGGCGGGTCAATCAGTTGCAGGTGGCGGGAATGTGCCAGCAGATG
CAGCTTCTGGAAGCGACCTCTCTGACTTAAAACGTCAAATGGAGCAAATGCATCAAGAGATACAAACGCTGAAAAAACAA
ATTGCCAGCGGGGCTGGAGCAGCGCCAGCCGATAAACCAACCCAAAATCGCGGTGGTTCTAAAAAAGCAATCAACAACGG
CAAGCAATTTAAAGCGCCTATTGGTAAAATCAACCATGTGCTAGGTGAGGCTAAGAAAGAGAATTTACAGTTAATCCGTG
GTTGTTGGGGCGAGTTATTATCAATGTTGATGGCATCTCAAGCAGCACTTTTAAATGACGCAGAACCTGTGGCTGCATCT
CAGGACACTTTTGTGTTAAAATTTAAGCATGAGATTCACTGTCAAATGGCGATGGATAATCCGAACTTTGTTGAAACCAT
CACATCGAGTATTGCCCGACTGACTCAAGTAAATTATACTTTTATTGGTATCCCAGAAGATCAATGGGCTGACGTAAGAG
AGAATTTCCTGCATAGTCATGGTAGCGACGGCGATGCGGAGGACGGCGCAAATCCAGAAGCTAAAAAACCAGCGGAAGAT
CCTTTTGTTGCAGAAGCCGCAAAACTCGTTGGTGAAGATTTGCTTGAAATTAAAGATTAA

Upstream 100 bases:

>100_bases
TATTGAAGAAGTAAATCAAAACAAACAACGTTTTGAAACTTCTTCAACAATACGTTATAATAAAACTACTAAAATGGTTT
TAGGTGAAGGAGAGTGGCAG

Downstream 100 bases:

>100_bases
AAAACAATAGAAGAAAGAGGAGATTATTCATGCGTGGAATGGGAAATATGCAAGGTATGATGAAACAAATGCAAAAAATG
CAAAAGGAAATGGCGAAAGC

Product: DNA polymerase III (gamma and tau subunits)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICK
GTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPH
KLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEI
TGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETLERALIDDDFVALAKR
ADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALIQLTQAGQSVAGGGNVPADAASGSDLSDLKRQMEQMHQEIQTLKKQ
IASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAAS
QDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDGDAEDGANPEAKKPAED
PFVAEAAKLVGEDLLEIKD

Sequences:

>Translated_579_residues
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICK
GTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPH
KLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEI
TGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETLERALIDDDFVALAKR
ADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALIQLTQAGQSVAGGGNVPADAASGSDLSDLKRQMEQMHQEIQTLKKQ
IASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAAS
QDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDGDAEDGANPEAKKPAED
PFVAEAAKLVGEDLLEIKD
>Mature_578_residues
AYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKG
TTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHK
LPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEIT
GSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETLERALIDDDFVALAKRA
DSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALIQLTQAGQSVAGGGNVPADAASGSDLSDLKRQMEQMHQEIQTLKKQI
ASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQ
DTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDGDAEDGANPEAKKPAEDP
FVAEAAKLVGEDLLEIKD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=265, Percent_Identity=26.4150943396226, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194306571, Length=265, Percent_Identity=26.4150943396226, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI194306567, Length=265, Percent_Identity=26.4150943396226, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI31563534, Length=296, Percent_Identity=24.3243243243243, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786676, Length=299, Percent_Identity=45.1505016722408, Blast_Score=275, Evalue=8e-75,
Organism=Escherichia coli, GI1787119, Length=284, Percent_Identity=25.7042253521127, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=258, Percent_Identity=25.968992248062, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554730, Length=223, Percent_Identity=27.8026905829596, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=282, Percent_Identity=24.468085106383, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=310, Percent_Identity=26.4516129032258, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324039, Length=292, Percent_Identity=26.7123287671233, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324478, Length=263, Percent_Identity=24.3346007604563, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859927, Length=265, Percent_Identity=23.3962264150943, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17647857, Length=318, Percent_Identity=22.9559748427673, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63442; Mature: 63311

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAK
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
AINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKY
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHEE
KVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITT
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
QDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEI
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHH
TGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
LEETLERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALIQLTQA
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
GQSVAGGGNVPADAASGSDLSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
KKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAAS
HHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSH
CCCEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCC
GSDGDAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAK
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
AINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKY
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHEE
KVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITT
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
QDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEI
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHH
TGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
LEETLERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALIQLTQA
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
GQSVAGGGNVPADAASGSDLSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
KKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAAS
HHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSH
CCCEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCC
GSDGDAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]