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The map label for this gene is clpP

Identifier: 226225016

GI number: 226225016

Start: 2514752

End: 2515348

Strand: Direct

Name: clpP

Synonym: Lm4b_02437

Alternate gene names: 226225016

Gene position: 2514752-2515348 (Clockwise)

Preceding gene: 226225014

Following gene: 226225018

Centisome position: 86.34

GC content: 39.2

Gene sequence:

>597_bases
ATGAACTTAATTCCAACAGTAATCGAACAAACTAGCCGCGGTGAACGTGCATATGACATTTATTCCCGTTTATTAAAAGA
CAGAATTATTATGTTAGGATCTGCAATTGATGATAACGTGGCGAATTCGATCGTTTCTCAATTACTCTTCTTAGATGCAC
AAGATCCTGAAAAAGATATTTTCCTATATATCAATTCACCAGGTGGAAGTATTTCAGCTGGTATGGCCATTTACGATACA
ATGAATTTCGTTAAAGCGGACGTACAAACTATCGGCATGGGTATGGCAGCTTCCATGGGCTCATTCTTACTAACAGCTGG
TGCAAATGGCAAACGGTTTGCCTTGCCAAACGCTGAAATTATGATTCACCAACCACTTGGTGGCGCTCAAGGTCAAGCGA
CTGAAATCGAAATCGCTGCTCGCCACATTTTAAAAATCAAAGAACGTATGAATACGATTATGGCTGAGAAAACTGGTCAA
CCGTATGAAGTCATTGCTCGTGATACAGATCGTGATAATTTCATGACTGCACAAGAAGCAAAAGATTACGGCTTAATTGA
TGATATCATCATTAACAAATCTGGCTTAAAAGGCTAA

Upstream 100 bases:

>100_bases
ATAATTCGCCTCAGACTTTATCGTTTGACCTAGTTTGACCATTCGTGTATGATATAACAAAGCTAATTTAAAATTCACAT
TTAACAGGAGGAATCTTGAT

Downstream 100 bases:

>100_bases
TAAAAAAAAGAGGTTTTGCACAAAATGCAAAACCTCTTTTTTTATACTTTATTTTACACGAAGCGCTGAATGTTTTCTTC
CGTAGAATGTATACACTAGT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIINKSGLKG

Sequences:

>Translated_198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIINKSGLKG
>Mature_198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIINKSGLKG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=51.0416666666667, Blast_Score=216, Evalue=1e-56,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=66.4948453608247, Blast_Score=280, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.1505376344086, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=55.7894736842105, Blast_Score=223, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21619; Mature: 21619

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDI
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEI
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCEEEEECCCCCEEECCCCEE
MIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQPYEVIARDTDRDNFMTAQEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
KDYGLIDDIIINKSGLKG
CCCCCHHHHEECCCCCCC
>Mature Secondary Structure
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDI
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEI
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCEEEEECCCCCEEECCCCEE
MIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQPYEVIARDTDRDNFMTAQEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
KDYGLIDDIIINKSGLKG
CCCCCHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]