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The map label for this gene is fabF [H]

Identifier: 226224809

GI number: 226224809

Start: 2295489

End: 2296730

Strand: Reverse

Name: fabF [H]

Synonym: Lm4b_02228

Alternate gene names: 226224809

Gene position: 2296730-2295489 (Counterclockwise)

Preceding gene: 226224810

Following gene: 226224808

Centisome position: 78.85

GC content: 39.61

Gene sequence:

>1242_bases
ATGGATAAGAGAAGAGTAGTTGTTACTGGTATTGGAGCTGTTACACCTATTGGAAATGATGCGGAAACTTCTTGGGAAAA
CGCAAAAAAAGGTGTTAATGGTGTTGCAAAAATGACAAGACTTAATCCGGATGACTTTCCGGTTAAAATTGCAGCAGAAT
TAAAAGATTTTGATGTAGAAAAATATCTAGAGAAAAAAGAAGCTCGTAAAATGGACCGTTTTACGCATTATGCAATTGCA
AGTGCTGAAATGGCCGTGCAAGACTCTGGTTTAGTTATTGATGATTCCAATGCAAACCGAGTTGGTGTTTGGATTGGTTC
AGGAATTGGTGGAATGGAAACTTTCGAAACACAATATGAAATTTTCTTAAATCGCGGTCATCGCCGAGTTAGCCCGTTTT
TCGTACCTATGATGATTCCAGATATGGGTTCAGGCCAGGTTTCTATTCGTTTTGGTGCTAAAGGCATTAATTCTACAACA
GTTACAGCTTGTGCAACTGCAACAAACTCAATCGGCGACGCGTTTAAAGTTATTGAGCGTGGAGATGCTGATGCAATGAT
TACTGGTGGAGCAGAAGCACCGATTACTAAAATGTCACTTGCTGGTTTTACTGCTAATAAAGCTTTGTCATTAAATCCAG
ATCCAGAAACTGCATGCCGTCCGTTTGATAAAGATCGTGATGGTTTTATTATTGGTGAAGGCGCAGGTATCGTTATTTTA
GAAGAATACGAACATGCAAAAGCACGTGGGGCAAAAATTTACGCTGAAATCGTTGGTTACGGTGCAACAGGAGATGCTTA
CCACATTACTGCTCCAGCTCCAAACGGTGAAGGTGCTGCGCGCGCAATGAAAATGGCGATTGATGATGCTGGCCTTACCC
CTGATAAAGTAGATTACATTAATGCCCACGGAACAAGTACACCGTACAATGATGAATACGAAACACAAGCTATTAAAACT
GTCTTTGGAGATCATGCGAAAAAATTAGCGATTAGTTCTACTAAGTCAATGACTGGACATACTCTAGGTGCGTCTGGCGG
AATAGAAGCTATTTTCGCCCTATTGACTATTCGTGATAATATTATTGCACCAACGATTCATTTGAAAAACCAAGATGAAG
TTTGTGACTTGGATTATGTTCCAAATGAAGCACGTGAGGCAAATGTAAATGTAGTAATTTCTAACTCTTTTGGCTTTGGT
GGTCACAATGCGACTTTAGTATTTAAAAGAATAGAAGACTAA

Upstream 100 bases:

>100_bases
TGCACTATTATTAATTTTAAATAAAGCCTTAACTTTATACTAGCTGCTGTCATTGGACAGAAGTTGTTTTTTATGAATCG
CAAAATAAGGAGATGAGTAA

Downstream 100 bases:

>100_bases
AATATAATCAAAAGCCTTACCTCTAAAAATGAGGTAAGGCTTTTTTTGAGCAAAAAACTAGCTTTCATTATTATGATTGG
TTACAATTAAATTGTACACA

Product: 3-oxoacyl-acyl-carrier protein synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDKRRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYLEKKEARKMDRFTHYAIA
SAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYEIFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTT
VTACATATNSIGDAFKVIERGDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVIL
EEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYINAHGTSTPYNDEYETQAIKT
VFGDHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDNIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFG
GHNATLVFKRIED

Sequences:

>Translated_413_residues
MDKRRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYLEKKEARKMDRFTHYAIA
SAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYEIFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTT
VTACATATNSIGDAFKVIERGDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVIL
EEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYINAHGTSTPYNDEYETQAIKT
VFGDHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDNIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFG
GHNATLVFKRIED
>Mature_413_residues
MDKRRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYLEKKEARKMDRFTHYAIA
SAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYEIFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTT
VTACATATNSIGDAFKVIERGDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVIL
EEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYINAHGTSTPYNDEYETQAIKT
VFGDHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDNIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFG
GHNATLVFKRIED

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=45.7831325301205, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=48.2352941176471, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI41872631, Length=424, Percent_Identity=26.4150943396226, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=49.3946731234867, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=40.7228915662651, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=34.2233009708738, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=40.4580152671756, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=27.3480662983425, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=25.8992805755396, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=36.3431151241535, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=43.0952380952381, Blast_Score=345, Evalue=2e-95,
Organism=Drosophila melanogaster, GI221330659, Length=401, Percent_Identity=26.6832917705736, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI19920632, Length=401, Percent_Identity=26.6832917705736, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24581345, Length=422, Percent_Identity=24.4075829383886, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44280; Mature: 44280

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVE
CCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
KYLEKKEARKMDRFTHYAIASAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYE
HHHHHHHHHHHHHHHHHHEECHHEEEECCCEEEECCCCCEEEEEEECCCCCCHHHHHHEE
IFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTTVTACATATNSIGDAFKVIER
EEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHC
GDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVIL
CCCCEEEECCCCCCEEEEEECCCCCCCEEEECCCCCHHCCCCCCCCCCEEEECCCCEEEE
EEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYI
ECCCCCHHCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHEEHHCCCCCCCCEEEE
NAHGTSTPYNDEYETQAIKTVFGDHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDN
ECCCCCCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
IIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFGGHNATLVFKRIED
EEEEEEEECCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MDKRRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVE
CCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHH
KYLEKKEARKMDRFTHYAIASAEMAVQDSGLVIDDSNANRVGVWIGSGIGGMETFETQYE
HHHHHHHHHHHHHHHHHHEECHHEEEECCCEEEECCCCCEEEEEEECCCCCCHHHHHHEE
IFLNRGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTTVTACATATNSIGDAFKVIER
EEEECCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHC
GDADAMITGGAEAPITKMSLAGFTANKALSLNPDPETACRPFDKDRDGFIIGEGAGIVIL
CCCCEEEECCCCCCEEEEEECCCCCCCEEEECCCCCHHCCCCCCCCCCEEEECCCCEEEE
EEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDYI
ECCCCCHHCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHEEHHCCCCCCCCEEEE
NAHGTSTPYNDEYETQAIKTVFGDHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDN
ECCCCCCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
IIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFGGHNATLVFKRIED
EEEEEEEECCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]