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The map label for this gene is cbh [H]

Identifier: 226224673

GI number: 226224673

Start: 2146081

End: 2147058

Strand: Reverse

Name: cbh [H]

Synonym: Lm4b_02088

Alternate gene names: 226224673

Gene position: 2147058-2146081 (Counterclockwise)

Preceding gene: 226224674

Following gene: 226224672

Centisome position: 73.71

GC content: 36.4

Gene sequence:

>978_bases
ATGTGTACGTCAATAACTTATACAACGAAGGATCACTATTTTGGAAGGAATTTCGATTATGAACTTTCTTACAAAGAGGT
TGTGGTTGTTACGCCGAAAAATTACCCGTTCCATTTTCGCAAGGTAGAGGATATAGAGAAGCATTATGCACTTATTGGTA
TTGCTGCTGTGATGGAAAACTACCCGTTGTATTACGATGCTACCAATGAAAAAGGCCTTAGTATGGCAGGACTCAATTTC
TCAGGAAATGCGGATTACAAGGATTTTGCAGAAGGTAAGGACAATGTAACGCCATTTGAATTTATTCCGTGGATTCTTGG
TCAATGCGCTACTGTAAAAGAAGCAAGAAGATTACTTCAGAGAATCAATCTCGTGAATATTAGCTTTAGTGAAAATTTGC
CGCTATCTCCTTTACATTGGTTGATGGCTGATCAAAACGAATCTATTGTAGTGGAATGTGTGAAAGATGGACTTCACATT
TATGATAATCCTGTTGGCGTGTTAACAAATAATCCAACATTTGATTACCAACTATTTAATTTAAACAATTATCGCGTTCT
TTCGAGTGAAACTCCAGAAAATAATTTTTCCAACGAGATTGATTTGGATGCTTATAGTCGTGGGATGGGCGGAATCGGCT
TACCTGGTGATTTATCTTCTATGTCTCGTTTTGTGAAAGCAACTTTTACCAAATTGAATTCTGTTTCAGGTGATTCTGAA
TCAGAGAGCATTAGCCAATTTTTCCATATTTTAGGCTCGGTGGAACAACAAAAAGGTCTTTGTGATGTTGGTGGGGAAAA
ATACGAGCACACCATTTATTCCTCATGTTGCAATATCGATAAAGGAATTTATTATTATAGAACATACGGAAACAGTCAAA
TTACTGGTGTGGATATGCACCAAGAGGATTTAGAGAGCAAAGAACTAGCTATTTATCCACTCGTTAATGAGCAACAACTA
AACATTGTTAATAAATAA

Upstream 100 bases:

>100_bases
TTGGCCATTTTTTGTGAAAAAAACCACAAATTATGTTTTACACAAAAGTCCGAGGGTACTGGTATACATGTATGGTGAAA
AATTTGAGGAGGGATTTTTA

Downstream 100 bases:

>100_bases
CTGTGAGGCTATGACAAGAAATTCTCTTGTCGTAGTTTTTTTGTGTAAAAAAACCAAAACTTGTCAGATGAAAAACAATT
TTGGGACCGAAAAGCTAAGT

Product: conjugated bile acid hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MCTSITYTTKDHYFGRNFDYELSYKEVVVVTPKNYPFHFRKVEDIEKHYALIGIAAVMENYPLYYDATNEKGLSMAGLNF
SGNADYKDFAEGKDNVTPFEFIPWILGQCATVKEARRLLQRINLVNISFSENLPLSPLHWLMADQNESIVVECVKDGLHI
YDNPVGVLTNNPTFDYQLFNLNNYRVLSSETPENNFSNEIDLDAYSRGMGGIGLPGDLSSMSRFVKATFTKLNSVSGDSE
SESISQFFHILGSVEQQKGLCDVGGEKYEHTIYSSCCNIDKGIYYYRTYGNSQITGVDMHQEDLESKELAIYPLVNEQQL
NIVNK

Sequences:

>Translated_325_residues
MCTSITYTTKDHYFGRNFDYELSYKEVVVVTPKNYPFHFRKVEDIEKHYALIGIAAVMENYPLYYDATNEKGLSMAGLNF
SGNADYKDFAEGKDNVTPFEFIPWILGQCATVKEARRLLQRINLVNISFSENLPLSPLHWLMADQNESIVVECVKDGLHI
YDNPVGVLTNNPTFDYQLFNLNNYRVLSSETPENNFSNEIDLDAYSRGMGGIGLPGDLSSMSRFVKATFTKLNSVSGDSE
SESISQFFHILGSVEQQKGLCDVGGEKYEHTIYSSCCNIDKGIYYYRTYGNSQITGVDMHQEDLESKELAIYPLVNEQQL
NIVNK
>Mature_325_residues
MCTSITYTTKDHYFGRNFDYELSYKEVVVVTPKNYPFHFRKVEDIEKHYALIGIAAVMENYPLYYDATNEKGLSMAGLNF
SGNADYKDFAEGKDNVTPFEFIPWILGQCATVKEARRLLQRINLVNISFSENLPLSPLHWLMADQNESIVVECVKDGLHI
YDNPVGVLTNNPTFDYQLFNLNNYRVLSSETPENNFSNEIDLDAYSRGMGGIGLPGDLSSMSRFVKATFTKLNSVSGDSE
SESISQFFHILGSVEQQKGLCDVGGEKYEHTIYSSCCNIDKGIYYYRTYGNSQITGVDMHQEDLESKELAIYPLVNEQQL
NIVNK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 36892; Mature: 36892

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTSITYTTKDHYFGRNFDYELSYKEVVVVTPKNYPFHFRKVEDIEKHYALIGIAAVMEN
CCCEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHC
YPLYYDATNEKGLSMAGLNFSGNADYKDFAEGKDNVTPFEFIPWILGQCATVKEARRLLQ
CCEEEECCCCCCCEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RINLVNISFSENLPLSPLHWLMADQNESIVVECVKDGLHIYDNPVGVLTNNPTFDYQLFN
HCCEEEEEECCCCCCCHHHHEECCCCCCEEEEEHHCCCEEECCCEEEEECCCCEEEEEEE
LNNYRVLSSETPENNFSNEIDLDAYSRGMGGIGLPGDLSSMSRFVKATFTKLNSVSGDSE
CCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
SESISQFFHILGSVEQQKGLCDVGGEKYEHTIYSSCCNIDKGIYYYRTYGNSQITGVDMH
HHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCC
QEDLESKELAIYPLVNEQQLNIVNK
HHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCTSITYTTKDHYFGRNFDYELSYKEVVVVTPKNYPFHFRKVEDIEKHYALIGIAAVMEN
CCCEEEEECCCCCCCCCCCEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHC
YPLYYDATNEKGLSMAGLNFSGNADYKDFAEGKDNVTPFEFIPWILGQCATVKEARRLLQ
CCEEEECCCCCCCEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RINLVNISFSENLPLSPLHWLMADQNESIVVECVKDGLHIYDNPVGVLTNNPTFDYQLFN
HCCEEEEEECCCCCCCHHHHEECCCCCCEEEEEHHCCCEEECCCEEEEECCCCEEEEEEE
LNNYRVLSSETPENNFSNEIDLDAYSRGMGGIGLPGDLSSMSRFVKATFTKLNSVSGDSE
CCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
SESISQFFHILGSVEQQKGLCDVGGEKYEHTIYSSCCNIDKGIYYYRTYGNSQITGVDMH
HHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCC
QEDLESKELAIYPLVNEQQLNIVNK
HHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]