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The map label for this gene is panE [C]

Identifier: 226224652

GI number: 226224652

Start: 2128820

End: 2129713

Strand: Reverse

Name: panE [C]

Synonym: Lm4b_02067

Alternate gene names: 226224652

Gene position: 2129713-2128820 (Counterclockwise)

Preceding gene: 226224653

Following gene: 226224651

Centisome position: 73.12

GC content: 36.8

Gene sequence:

>894_bases
ATGGCGAACCAACTAAAAGTAGGAATTATTGGAGCAGGAGCGATGGGGCTTTTATACGCAGCAAATTTTGCCAATACATC
CGAGCTCACTCTTTTTACGCGGAGAAAAGAACAAAGCGATTTATTAAATCAAAAAGGTCTTTCTTTAAAAGATAATTCCG
AATTAAAAAATATACATATACATGCCACAATAATAACAGATATTAAAAAGTTATCAGAACAACAATTATTAATTATCGCA
GTTAAACAATACTCACTAAAAAGCATTTTGCCACTGCTACAGTCGATACCTGAACGAGTGCCGTTACTATTCATCCAAAA
TGGAGCGGCGCATTTAGATAGCATGCCGCTACTCGGTAATAAACGAACTATTTTGCTAGGTATTAGCGAACACGGGGCGG
GGCGGGAAGATGATACAACAGTCATTTGGCGTGGTCATGGCCGAACAAAGTATAGTATTTATCAAGGCGAACTAAGTGAG
GCGGTAACAAAAACATTAGACTCAAATCCAGATTTTCCAGTTGAAAAACATGCTAGTTACTTAGAAATTATAAGTGAAAA
ATTATTTATTAATGCAGTAATTAATCCGCTCACAGCTGTTCTTCAAGTCCAAAATGGAAAGCTCCTTGAAAATAAAGAAT
GGCACGAGTTATTAAAGACGATTGTAAAAGAAATACAAACGGTTTTGCCAGTAGAAAATGCTTTAGAAAAAGTGGAAGTA
ATCTGCCAAGTGACAGCTACTAATTTTTCTTCGATGGCTCTTGACCGAATGAATAATCGAATGACAGAAATTGATGGAAT
CGTGCTGCCAATTTTAGAAAAAGGGGAGTCACTTCCTACGCTTCATGCGTTATATCATCTAATTAAAGGGTTGGAAGGAG
AAAGCGATGTTTGA

Upstream 100 bases:

>100_bases
GACGCCATGGGTCTTTCGAGGTTTTTGTTTGCGCACAAAAGTGCAAAAGAATGCTACTTCTGATAAAATAAAAGCATTAA
TCAATATGGAGCTGAACTAA

Downstream 100 bases:

>100_bases
TTGGTTAACTAATTCAACAGCAATAATTATTATTTTACCTGTTGTGGTGTTTATTTTGACGATGTTTTTTTCCAGTTTCA
AACTAAAGAAAAGTCAGCGG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MANQLKVGIIGAGAMGLLYAANFANTSELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHIHATIITDIKKLSEQQLLIIA
VKQYSLKSILPLLQSIPERVPLLFIQNGAAHLDSMPLLGNKRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELSE
AVTKTLDSNPDFPVEKHASYLEIISEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEV
ICQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV

Sequences:

>Translated_297_residues
MANQLKVGIIGAGAMGLLYAANFANTSELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHIHATIITDIKKLSEQQLLIIA
VKQYSLKSILPLLQSIPERVPLLFIQNGAAHLDSMPLLGNKRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELSE
AVTKTLDSNPDFPVEKHASYLEIISEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEV
ICQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV
>Mature_296_residues
ANQLKVGIIGAGAMGLLYAANFANTSELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHIHATIITDIKKLSEQQLLIIAV
KQYSLKSILPLLQSIPERVPLLFIQNGAAHLDSMPLLGNKRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELSEA
VTKTLDSNPDFPVEKHASYLEIISEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEVI
CQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=306, Percent_Identity=25.8169934640523, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32988; Mature: 32857

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQLKVGIIGAGAMGLLYAANFANTSELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHI
CCCCEEEEEEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCEEEEE
HATIITDIKKLSEQQLLIIAVKQYSLKSILPLLQSIPERVPLLFIQNGAAHLDSMPLLGN
EEEHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCC
KRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELSEAVTKTLDSNPDFPVEKHASY
CCEEEEEECCCCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
LEIISEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEV
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ICQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV
HHHHHCCCHHHHHHHHHHCHHHHHCCEEEEHHHCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ANQLKVGIIGAGAMGLLYAANFANTSELTLFTRRKEQSDLLNQKGLSLKDNSELKNIHI
CCCEEEEEEECCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCEEEEE
HATIITDIKKLSEQQLLIIAVKQYSLKSILPLLQSIPERVPLLFIQNGAAHLDSMPLLGN
EEEHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCC
KRTILLGISEHGAGREDDTTVIWRGHGRTKYSIYQGELSEAVTKTLDSNPDFPVEKHASY
CCEEEEEECCCCCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
LEIISEKLFINAVINPLTAVLQVQNGKLLENKEWHELLKTIVKEIQTVLPVENALEKVEV
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ICQVTATNFSSMALDRMNNRMTEIDGIVLPILEKGESLPTLHALYHLIKGLEGESDV
HHHHHCCCHHHHHHHHHHCHHHHHCCEEEEHHHCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]