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The map label for this gene is mngR [H]

Identifier: 226224601

GI number: 226224601

Start: 2064154

End: 2064855

Strand: Reverse

Name: mngR [H]

Synonym: Lm4b_02015

Alternate gene names: 226224601

Gene position: 2064855-2064154 (Counterclockwise)

Preceding gene: 226224602

Following gene: 226224600

Centisome position: 70.89

GC content: 34.19

Gene sequence:

>702_bases
ATGGGAGCTAAAAAGCCACTTTTTGAAGTAATAGCTTCAGAAATAAAAGATAGTATTAATCGCGATGAATATAAGCCGGG
AATGCTAATGCCGAACGAAACAGCCTTGCAAGAAATTTTTTCTAGCAGTCGGACAACGATTCGCCGCGCGGTAGATTTAT
TAGTCGAAGAAGGTTTAGTTGTTCGTAAAAACGGTGTTGGGCTATACGTTCAACCAAAACTAACAGCTCAGAACATTTTA
GAAATGACAGGTGTTATGAAAACCGATACCAATGAAAATCTAAAAAAAGACATTAAAGACTTTTACATCCGTAAAGCTGG
GAAATTTTACGCAGAGAAGTTTGGTATAAAAGAGAATGAACTTGTGTATTCTATCAAGTTTGTCCAAAAAAGTGAGCATG
GTGTCACACTAGATCGCTTAATTTTACCGTTAAGTTTATACCCTGATTTACAAGCAAAGGATTTTCAAATTATTAATATT
ATTGAGCTTGTTAATTCAGGTAAATATAAATTATTTGAGCTTGAGCAGGAACTTCAACTTATTTTAGCTGGGAATGAGCA
AATCAAAAATATGCATATAGACGAAAATGATCCTGTTTTCAAATTGAGTAGTGTCTTTTATGCAGAAAACGAGATGCCAA
TTGCCATCCAATATCATTATGAAGATGCTGAGTCGACCAAATATGTAGTTGATTTTAACTAA

Upstream 100 bases:

>100_bases
GATGAACCTTTTGAGTACAGTAAACAATATCTAATTGGTAATCAAATCAAATACAAAATCAATGCGAAAAACATATTTGA
TTACTTGGAGGATGAGTGAA

Downstream 100 bases:

>100_bases
TACGAAGGAGGAAGAAAAAATGATTCAATTTCTAAGAGTGGACCATCGTTTACTACATGGACAAGTAGCTGTGTCTTGGT
TTAATGCTTTAGATGTAAAT

Product: transcription regulator GntR family

Products: NA

Alternate protein names: Fatty acyl-responsive regulator; Protein P30 [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MGAKKPLFEVIASEIKDSINRDEYKPGMLMPNETALQEIFSSSRTTIRRAVDLLVEEGLVVRKNGVGLYVQPKLTAQNIL
EMTGVMKTDTNENLKKDIKDFYIRKAGKFYAEKFGIKENELVYSIKFVQKSEHGVTLDRLILPLSLYPDLQAKDFQIINI
IELVNSGKYKLFELEQELQLILAGNEQIKNMHIDENDPVFKLSSVFYAENEMPIAIQYHYEDAESTKYVVDFN

Sequences:

>Translated_233_residues
MGAKKPLFEVIASEIKDSINRDEYKPGMLMPNETALQEIFSSSRTTIRRAVDLLVEEGLVVRKNGVGLYVQPKLTAQNIL
EMTGVMKTDTNENLKKDIKDFYIRKAGKFYAEKFGIKENELVYSIKFVQKSEHGVTLDRLILPLSLYPDLQAKDFQIINI
IELVNSGKYKLFELEQELQLILAGNEQIKNMHIDENDPVFKLSSVFYAENEMPIAIQYHYEDAESTKYVVDFN
>Mature_232_residues
GAKKPLFEVIASEIKDSINRDEYKPGMLMPNETALQEIFSSSRTTIRRAVDLLVEEGLVVRKNGVGLYVQPKLTAQNILE
MTGVMKTDTNENLKKDIKDFYIRKAGKFYAEKFGIKENELVYSIKFVQKSEHGVTLDRLILPLSLYPDLQAKDFQIINII
ELVNSGKYKLFELEQELQLILAGNEQIKNMHIDENDPVFKLSSVFYAENEMPIAIQYHYEDAESTKYVVDFN

Specific function: Represses mngA and mngB. Regulates its own expression [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=219, Percent_Identity=27.3972602739726, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790118, Length=220, Percent_Identity=25.4545454545455, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082252, Length=238, Percent_Identity=23.9495798319328, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26797; Mature: 26666

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAKKPLFEVIASEIKDSINRDEYKPGMLMPNETALQEIFSSSRTTIRRAVDLLVEEGLV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCEE
VRKNGVGLYVQPKLTAQNILEMTGVMKTDTNENLKKDIKDFYIRKAGKFYAEKFGIKENE
EEECCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LVYSIKFVQKSEHGVTLDRLILPLSLYPDLQAKDFQIINIIELVNSGKYKLFELEQELQL
EEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHEEE
ILAGNEQIKNMHIDENDPVFKLSSVFYAENEMPIAIQYHYEDAESTKYVVDFN
EEECCHHHCEECCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEC
>Mature Secondary Structure 
GAKKPLFEVIASEIKDSINRDEYKPGMLMPNETALQEIFSSSRTTIRRAVDLLVEEGLV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCEE
VRKNGVGLYVQPKLTAQNILEMTGVMKTDTNENLKKDIKDFYIRKAGKFYAEKFGIKENE
EEECCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LVYSIKFVQKSEHGVTLDRLILPLSLYPDLQAKDFQIINIIELVNSGKYKLFELEQELQL
EEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHEEE
ILAGNEQIKNMHIDENDPVFKLSSVFYAENEMPIAIQYHYEDAESTKYVVDFN
EEECCHHHCEECCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548486; 9278503; 9063979; 8905232; 7805834 [H]