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The map label for this gene is pdp

Identifier: 226224591

GI number: 226224591

Start: 2055195

End: 2056496

Strand: Reverse

Name: pdp

Synonym: Lm4b_02005

Alternate gene names: 226224591

Gene position: 2056496-2055195 (Counterclockwise)

Preceding gene: 226224592

Following gene: 226224580

Centisome position: 70.6

GC content: 42.09

Gene sequence:

>1302_bases
ATGAGAATGGTGGATATTATTTCCAAGAAAAGGGACGGCAAAGCTTTATCAACAGAAGAAATTCAGTTTTTCATTGATGG
CTATACAAATGGGGAAATTCCAGATTATCAAGCAAGTGCTCTAGCCATGGCAATCTTTTTCCAAGATATGAATGATCAAG
AACGCGCAGATTTAACAATGGCAATGGTTGGCTCTGGCGATACGATTGACCTATCCGCAATTGAAGGAATCAAAGTCGAT
AAACATAGTACTGGCGGTGTTGGTGATACGACGACACTTGTTCTTGCTCCGCTCGTAGCAGCAGTTGGCGTACCGGTTGC
AAAGATGTCTGGCCGTGGCTTAGGTCATACAGGAGGAACCATTGATAAACTAGAATCTATCGAAGGCTTCCATATCGAAC
TAGATAAGAAAGATTTCATTGACCTAGTAAATCGCGACAAAGTAGCAGTTATTGGTCAATCAGGTAATCTTACACCAGCA
GATAAAAAAATGTACGCGCTTCGTGATGTAACAGGAACCGTAAACTCAATACCACTAATTGCAAGCTCTATTATGAGTAA
AAAAATCGCAGCGGGCGCAGATGCAATCGTACTTGATGTAAAAACAGGTGCTGGTGCATTTATGAAAACCGACGAGGATG
CCGAAAACCTAGCACATGCAATGGTTCGCATCGGTAATAACGTTGGTAGAAATACGATGGCAGTCATTTCTGATATGTCC
CAACCACTTGGCGAAGCAATCGGAAATGCTTTAGAAGTAAAAGAAGCCATCGATACATTAAAAGGCCAAGGACCAGAAGA
TTTAACAGAATTAGTTCTTGTACTTGGTAGTCAAATGGTCGTACTAGCCAAACAAGCGGAAACACTCGACGAAGCCCGCG
CTAAATTAATTGAAGTAATCGAAAACGGTGCAGCACTTGAGAAATTCAAAACATTCCTTTCCAATCAAGGTGGCGATGCA
AGCATTGTTGATCACCCAGAAAAACTTCCGCAAGCAAAATACCAAATCGAAGTACCCGCTAAATCATCTGGCTTCGTAAG
TCAAATCGTTGCCGATGAAATTGGCATTGCTGCAATGATCCTAGGCGCCGGTCGCGCAACGAAGGAAGACGAAATCAATC
TAGCAGTAGGTTTAATGCTACGCAAAAAAGTGGGCGATGCTGTTAAGGAAGGCGAATCACTCGTAACGATTTTCGCTGAC
CAAGAAGATGTCGAAAACGTAAAAGCAAAAATCTACGAAAACATTCAAATTTCCGACCACGCAACAGCACCAACCCTTGT
TCATAAAGTTATTACAGAATAA

Upstream 100 bases:

>100_bases
CATGTTCTTGTTTAGTAAAACGGTTTACTTAAAAAGTGTAACCGTTCTCAATAAAGGTACATAAAATGCTAAAGTGGACA
AAAAGAAAGGGTGAAGAGAA

Downstream 100 bases:

>100_bases
AAGAAAGCTCCCAATTTAATTTGGGAGCTTTCTTTATCAATTTTCCGCGGCTTCAATCTGTTCCAACATATCCGGCGTAC
TTAAATCACTTCTTAAGAAT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDIISKKRDGKALSTEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTMAMVGSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESIEGFHIELDKKDFIDLVNRDKVAVIGQSGNLTPA
DKKMYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVKEAIDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVIENGAALEKFKTFLSNQGGDA
SIVDHPEKLPQAKYQIEVPAKSSGFVSQIVADEIGIAAMILGAGRATKEDEINLAVGLMLRKKVGDAVKEGESLVTIFAD
QEDVENVKAKIYENIQISDHATAPTLVHKVITE

Sequences:

>Translated_433_residues
MRMVDIISKKRDGKALSTEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTMAMVGSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESIEGFHIELDKKDFIDLVNRDKVAVIGQSGNLTPA
DKKMYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVKEAIDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVIENGAALEKFKTFLSNQGGDA
SIVDHPEKLPQAKYQIEVPAKSSGFVSQIVADEIGIAAMILGAGRATKEDEINLAVGLMLRKKVGDAVKEGESLVTIFAD
QEDVENVKAKIYENIQISDHATAPTLVHKVITE
>Mature_433_residues
MRMVDIISKKRDGKALSTEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTMAMVGSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESIEGFHIELDKKDFIDLVNRDKVAVIGQSGNLTPA
DKKMYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMS
QPLGEAIGNALEVKEAIDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVIENGAALEKFKTFLSNQGGDA
SIVDHPEKLPQAKYQIEVPAKSSGFVSQIVADEIGIAAMILGAGRATKEDEINLAVGLMLRKKVGDAVKEGESLVTIFAD
QEDVENVKAKIYENIQISDHATAPTLVHKVITE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=443, Percent_Identity=37.2460496613996, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI4503445, Length=443, Percent_Identity=37.2460496613996, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI166158922, Length=443, Percent_Identity=37.2460496613996, Blast_Score=273, Evalue=3e-73,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=47.029702970297, Blast_Score=332, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46003; Mature: 46003

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDIISKKRDGKALSTEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTM
CCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCEEE
AMVGSGDTIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESIEGFHIELDKKDFIDLVNRDKVAVIGQSGNLTPADKKMYALRDVTGTVNSIPLI
HHHHHCCCCEEEEECCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QPLGEAIGNALEVKEAIDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
ENGAALEKFKTFLSNQGGDASIVDHPEKLPQAKYQIEVPAKSSGFVSQIVADEIGIAAMI
HCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHE
LGAGRATKEDEINLAVGLMLRKKVGDAVKEGESLVTIFADQEDVENVKAKIYENIQISDH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCEECCC
ATAPTLVHKVITE
CCHHHHHHHHHCC
>Mature Secondary Structure
MRMVDIISKKRDGKALSTEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTM
CCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCEEE
AMVGSGDTIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESIEGFHIELDKKDFIDLVNRDKVAVIGQSGNLTPADKKMYALRDVTGTVNSIPLI
HHHHHCCCCEEEEECCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QPLGEAIGNALEVKEAIDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
ENGAALEKFKTFLSNQGGDASIVDHPEKLPQAKYQIEVPAKSSGFVSQIVADEIGIAAMI
HCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHE
LGAGRATKEDEINLAVGLMLRKKVGDAVKEGESLVTIFADQEDVENVKAKIYENIQISDH
EECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCEECCC
ATAPTLVHKVITE
CCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]