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The map label for this gene is hisC

Identifier: 226224529

GI number: 226224529

Start: 1988457

End: 1989539

Strand: Reverse

Name: hisC

Synonym: Lm4b_01942

Alternate gene names: 226224529

Gene position: 1989539-1988457 (Counterclockwise)

Preceding gene: 226224530

Following gene: 226224528

Centisome position: 68.31

GC content: 38.78

Gene sequence:

>1083_bases
ATGAAATGGAAAAAATCACTTACAGGTCTATCTTCTTATAAACCTGGAAAACGCGAAGAAGAAGTGATGGCAGAACTTGG
TTTAACGAAAATCACCAAACTATCATCTAACGAAAACCCACTGGGAACTTCTCCAAAAGTGGCGGAGCTTCAAGCCGATT
CTAGTGTGGAAACAGAAATTTATCCAGATGGCTGGGCTTCTAGCTTGCGTACAGTGGTCGCTGATTTCTACCAACTGGAA
GAAGAGGAACTGATTTTTACAGCTGGTGTGGATGAACTGATTGAACTGTTGACGCGGGTTTTACTGGATACGACAAAAAA
TACAGTGATGGCGACACCGACATTTGTGCAGTATCGTCAAAATGCGTTAATCGAAGGCGCCGAAGTAAGAGAAATTCCGC
TACTTGTGGATGGTGCGCATGATTTAGATGGTATGTTGAATGCGATTGATGACAATACGACGATTGTTTGGGTTTGCAAT
CCGAATAACCCAACTGGGAATTACATTGATTTAGCAGATATTCAAGCGTTTTTAGATAAAGTACCAAGTGATGTACTTGT
TGTTTTAGATGAAGCATATATTGAATATGTGACGCCACAGCCTGAAAAACATGAAAAACTAATTCGCACTTATAAAAATT
TAATTATTACCCGGACTTTTAGTAAAATTTATGGTTTGGCAAGCGCTCGTGTTGGTTATGGTATTGCGGATAAAGCAATC
ATTGAGCAACTAAATATCGTTCGTCCGCCGTTTAATACAACGAGCATCGGTCAAAAATTAGCAATAGAAGCAATAAAGGA
TCAAGCTTTTATTGAAGCATGCCGAACTTCTAATGCAAATGGAATTAAACAATACGAAGCGTTTGCGAAACGTTTTGAGC
AAGTAAAACTGTATCCAGCGAATGGCAACTTTGTTTTAATAGATTTAGGAATTGAAGCAGGAACTATTTTTAGCTACTTG
GAAAAAAATGGCTATATTACGCGTTCTGGCGCGGCGCTTGGTTTTCCAACTGCTGTTCGAATTACGATCGGAAAAGAAGA
GGAAAATAGTGCGGTAATTGCACTTTTAGAAAAATTATTGTAA

Upstream 100 bases:

>100_bases
TATTCACAGATCTACATAAACCACTCGAAGCCATCAACCATGTCTACTTACGAGGAGCAAAAGTACTGCGCCCAGATTTA
GTAAAAGAGGAGGATGCGTA

Downstream 100 bases:

>100_bases
GTGTTTGGAGGCGTTTTTGAATGAAAGGGACGGTAGTTATTGTTGGGCTTGGGTTAATTGGCGGTTCTATTGCCCTTGCG
ATTAAAGCCAAACACCCAGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKWKKSLTGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAELQADSSVETEIYPDGWASSLRTVVADFYQLE
EEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQNALIEGAEVREIPLLVDGAHDLDGMLNAIDDNTTIVWVCN
PNNPTGNYIDLADIQAFLDKVPSDVLVVLDEAYIEYVTPQPEKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKAI
IEQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRTSNANGIKQYEAFAKRFEQVKLYPANGNFVLIDLGIEAGTIFSYL
EKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL

Sequences:

>Translated_360_residues
MKWKKSLTGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAELQADSSVETEIYPDGWASSLRTVVADFYQLE
EEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQNALIEGAEVREIPLLVDGAHDLDGMLNAIDDNTTIVWVCN
PNNPTGNYIDLADIQAFLDKVPSDVLVVLDEAYIEYVTPQPEKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKAI
IEQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRTSNANGIKQYEAFAKRFEQVKLYPANGNFVLIDLGIEAGTIFSYL
EKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL
>Mature_360_residues
MKWKKSLTGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAELQADSSVETEIYPDGWASSLRTVVADFYQLE
EEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQNALIEGAEVREIPLLVDGAHDLDGMLNAIDDNTTIVWVCN
PNNPTGNYIDLADIQAFLDKVPSDVLVVLDEAYIEYVTPQPEKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKAI
IEQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRTSNANGIKQYEAFAKRFEQVKLYPANGNFVLIDLGIEAGTIFSYL
EKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=359, Percent_Identity=27.2980501392758, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322075, Length=369, Percent_Identity=26.5582655826558, Blast_Score=99, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39863; Mature: 39863

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWKKSLTGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAELQADSSVETEI
CCCHHHHCCCCCCCCCCHHHHHHHHHCHHHHEECCCCCCCCCCCCCCEEEECCCCCCCEE
YPDGWASSLRTVVADFYQLEEEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQ
CCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHH
NALIEGAEVREIPLLVDGAHDLDGMLNAIDDNTTIVWVCNPNNPTGNYIDLADIQAFLDK
HHHCCCCCEEECCEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHH
VPSDVLVVLDEAYIEYVTPQPEKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKAI
CCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IEQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRTSNANGIKQYEAFAKRFEQVKLYPA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEC
NGNFVLIDLGIEAGTIFSYLEKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL
CCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MKWKKSLTGLSSYKPGKREEEVMAELGLTKITKLSSNENPLGTSPKVAELQADSSVETEI
CCCHHHHCCCCCCCCCCHHHHHHHHHCHHHHEECCCCCCCCCCCCCCEEEECCCCCCCEE
YPDGWASSLRTVVADFYQLEEEELIFTAGVDELIELLTRVLLDTTKNTVMATPTFVQYRQ
CCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHH
NALIEGAEVREIPLLVDGAHDLDGMLNAIDDNTTIVWVCNPNNPTGNYIDLADIQAFLDK
HHHCCCCCEEECCEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHH
VPSDVLVVLDEAYIEYVTPQPEKHEKLIRTYKNLIITRTFSKIYGLASARVGYGIADKAI
CCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IEQLNIVRPPFNTTSIGQKLAIEAIKDQAFIEACRTSNANGIKQYEAFAKRFEQVKLYPA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEC
NGNFVLIDLGIEAGTIFSYLEKNGYITRSGAALGFPTAVRITIGKEEENSAVIALLEKLL
CCCEEEEEECCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]