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The map label for this gene is pbuX [H]

Identifier: 226224487

GI number: 226224487

Start: 1944713

End: 1946020

Strand: Reverse

Name: pbuX [H]

Synonym: Lm4b_01900

Alternate gene names: 226224487

Gene position: 1946020-1944713 (Counterclockwise)

Preceding gene: 226224488

Following gene: 226224486

Centisome position: 66.81

GC content: 40.83

Gene sequence:

>1308_bases
ATGTTAGGTAAAGGGAAAATTGCAGCTTTAGGATTTCAACATGTTCTAGCAATGTATGCAGGAGCAGTAATCGTTCCACT
ATTAATTGGTGGAGCATTAGGTTTTAATGGAGAAGAAATGACTTACTTAGTTTCGATTGATATTTTTATGTGCGGGATTG
CGACATTGCTACAATTAACGGTTAACCGCTTCTTTGGAATTGGTTTACCGGTTGTACTTGGATGTGCGGTTCAAGCTATT
GCGCCGATTATTTTAATTGGACAAGATATGGGCATTGGCGCGATTTACGGTTCGATTATTGTTTCAGGACTTTTTGTATT
ATTAATAGCACCATTTTTCTCCAAAGTTGTACGATTTTTCCCTCCTGTTGTGACTGGTTCGGTTGTAACAGTGATTGGTT
TAACACTTATTCCCGTTGCAATTAATAATCTTGCTGGTGGAGAAGGAGCAAAAGATTTTGGCTCAATGTATAATCTCGGC
CTTGGTTTTGGAACATTACTTTTAATTATTTTAGTGTATCGTTTTGGACAAGGGTTTTCGAAGGCGATTGCTGTTTTAAT
TGGTCTGGTTGGTGGTTCGCTTTTTGCAGCGCTTTATAAAGGGATCTCGCTTGGTCCTGTGAGTGAGGCGAGCTGGTTCC
ATATGCCAAAACCATTTTATTTTGGCACACCGACCTTTGAGTGGCCGGCAATTATTACGATGATTTTAATTGCGCTTGTC
AGCATGGTGGAATCAACGGGAGTATATTTCGCTTTATCTGATATTACCGAACGCAAATTAACGCAAAAAGATTTAACGCG
TGGTTACCGGGCAGAAGGGCTTGCGATTATGCTTGGCGGCGTATTTAATACATTCCCCTATACGGCTTATTCGCAAAACG
TTGGACTCGTTCAACTTTCTGGTATTAAAACACGTAAAGTGATTTATGCGGCAGCTGGTTTCCTTATTGTTCTTGGTCTG
ATTCCAAAAATTGGCGCAGTGACAACGATTATTCCGACACCAGTTCTCGGCGGCGCTATGGTCGCGATGTTCGGCATGGT
TGTCGCACAAGGGATTAAGATGCTTGGAAAAGTTAATTTCACTTCTCAAGAAAACTTGTTAATCATTGCGTGTGCAGTTG
GTGTTGGTTTAGGCGTTACAGTCGTACCAGATTTGTTCAATGCCTTCCCATCCTTTGTTCGCTTATTTACGAGTAATGGA
ATTGTTGCGGGCAGTGTGACAGCAATTACACTGAATATCATTTTCAATATGATTCCACATCGCAAAGATAAAAAAGTAGC
AGATCCAGAACCACAACATGCGAAGTAA

Upstream 100 bases:

>100_bases
CGAATTATTAAATAAAACAGGGATTCCAGTTTATTCACTAGCACGAATTGCCTCACTTGAAAACGAAGAAATCTTATTTT
TAGAGGAGGAATAGGAGTAA

Downstream 100 bases:

>100_bases
AAAATAAAACAGTTTTAATTGGGCTATTTTTTCTCAGTTACTTATACACATTCATTTATTTGAAAGCGGAATTGGTCTAT
ATCAATTTCGCTTTTTTGCT

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLGKGKIAALGFQHVLAMYAGAVIVPLLIGGALGFNGEEMTYLVSIDIFMCGIATLLQLTVNRFFGIGLPVVLGCAVQAI
APIILIGQDMGIGAIYGSIIVSGLFVLLIAPFFSKVVRFFPPVVTGSVVTVIGLTLIPVAINNLAGGEGAKDFGSMYNLG
LGFGTLLLIILVYRFGQGFSKAIAVLIGLVGGSLFAALYKGISLGPVSEASWFHMPKPFYFGTPTFEWPAIITMILIALV
SMVESTGVYFALSDITERKLTQKDLTRGYRAEGLAIMLGGVFNTFPYTAYSQNVGLVQLSGIKTRKVIYAAAGFLIVLGL
IPKIGAVTTIIPTPVLGGAMVAMFGMVVAQGIKMLGKVNFTSQENLLIIACAVGVGLGVTVVPDLFNAFPSFVRLFTSNG
IVAGSVTAITLNIIFNMIPHRKDKKVADPEPQHAK

Sequences:

>Translated_435_residues
MLGKGKIAALGFQHVLAMYAGAVIVPLLIGGALGFNGEEMTYLVSIDIFMCGIATLLQLTVNRFFGIGLPVVLGCAVQAI
APIILIGQDMGIGAIYGSIIVSGLFVLLIAPFFSKVVRFFPPVVTGSVVTVIGLTLIPVAINNLAGGEGAKDFGSMYNLG
LGFGTLLLIILVYRFGQGFSKAIAVLIGLVGGSLFAALYKGISLGPVSEASWFHMPKPFYFGTPTFEWPAIITMILIALV
SMVESTGVYFALSDITERKLTQKDLTRGYRAEGLAIMLGGVFNTFPYTAYSQNVGLVQLSGIKTRKVIYAAAGFLIVLGL
IPKIGAVTTIIPTPVLGGAMVAMFGMVVAQGIKMLGKVNFTSQENLLIIACAVGVGLGVTVVPDLFNAFPSFVRLFTSNG
IVAGSVTAITLNIIFNMIPHRKDKKVADPEPQHAK
>Mature_435_residues
MLGKGKIAALGFQHVLAMYAGAVIVPLLIGGALGFNGEEMTYLVSIDIFMCGIATLLQLTVNRFFGIGLPVVLGCAVQAI
APIILIGQDMGIGAIYGSIIVSGLFVLLIAPFFSKVVRFFPPVVTGSVVTVIGLTLIPVAINNLAGGEGAKDFGSMYNLG
LGFGTLLLIILVYRFGQGFSKAIAVLIGLVGGSLFAALYKGISLGPVSEASWFHMPKPFYFGTPTFEWPAIITMILIALV
SMVESTGVYFALSDITERKLTQKDLTRGYRAEGLAIMLGGVFNTFPYTAYSQNVGLVQLSGIKTRKVIYAAAGFLIVLGL
IPKIGAVTTIIPTPVLGGAMVAMFGMVVAQGIKMLGKVNFTSQENLLIIACAVGVGLGVTVVPDLFNAFPSFVRLFTSNG
IVAGSVTAITLNIIFNMIPHRKDKKVADPEPQHAK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=442, Percent_Identity=24.4343891402715, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI40316845, Length=442, Percent_Identity=24.4343891402715, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI44680145, Length=452, Percent_Identity=25.2212389380531, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI44680143, Length=457, Percent_Identity=24.945295404814, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082181, Length=437, Percent_Identity=40.9610983981693, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790087, Length=422, Percent_Identity=32.4644549763033, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI87082178, Length=426, Percent_Identity=31.924882629108, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081818, Length=452, Percent_Identity=29.2035398230088, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788843, Length=432, Percent_Identity=28.7037037037037, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17558856, Length=197, Percent_Identity=34.010152284264, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17541904, Length=170, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17542262, Length=176, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542260, Length=193, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=197, Percent_Identity=24.8730964467005, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21356175, Length=432, Percent_Identity=25.6944444444444, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45852; Mature: 45852

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01116 XANTH_URACIL_PERMASE ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]