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The map label for this gene is fhs [H]

Identifier: 226224480

GI number: 226224480

Start: 1938743

End: 1940425

Strand: Reverse

Name: fhs [H]

Synonym: Lm4b_01893

Alternate gene names: 226224480

Gene position: 1940425-1938743 (Counterclockwise)

Preceding gene: 226224481

Following gene: 226224479

Centisome position: 66.62

GC content: 41.71

Gene sequence:

>1683_bases
ATGTCAAATAAAGTGAAATCAGATATTGAAATTGCATCAAAAGCAGAAATTCTACCAGTTACGACTATTGCGGAACATTT
AGGACTAGACGCAGATGCACTCGAACTTTACGGAAAGTATAAAGCAAAGTTATCCTATGATACCATTCACTCGCTAAAAG
ATAAAGAACCAGGAAAACTTGTTCTTGTTACGGCGATTAACCCAACGCCTGCTGGTGAAGGGAAATCGACAGTGACAGTT
GGTCTTGGCGACGCACTGTCTAAAAAAGATAAGAAAACCGTTATTGCACTTCGCGAACCATCGCTCGGACCTACCATGGG
TATTAAGGGCGGGGCAACAGGTGGCGGATACGCGCAGGTTATTCCAATGGAAGATATTAATTTACATTTTACTGGTGATT
TCCACGCGATTACAGCAGCAAACAATGCTTTATCGGCATTTATTGATAACCATATGCAACAAGGGAATGACCTAGATATT
GACGGCCGAAGAATCGTTTGGAAACGTGTGGTTGATTTGAACGACCGTGCACTTCGAAAAGTGGTTGTTGGTCTTGGAGG
TCCTATTCAAGGGGTTCCACGTGAAGACGGTTTTGATATTACGGTTGCTTCTGAAATTATGGCGATCATTTGTTTAGCAA
GTGATTTAAAAGATTTAAAGAAACGTTTAAGTGAAATCGTGATCGGTTATAACTATAAAAAAGAACCAATTACAGTTGGC
GAAATGGGCTACGAAGGCGCTCTAACCTTACTATTAAAAGATGCTTTAAAACCTAATTTGGTGCAAACATTAGAACATAC
ACCTGCCATCGTACACGGTGGACCTTTTGCTAATATTGCTCACGGATGTAATAGTGTTTCTGCGACAAGCACAGCACTTC
GACTAGGTGAGTATGTAGTGACAGAGGCTGGATTTGGTGCAGACCTTGGTGCCGAGAAATTTTTAGATATTAAAGTTCCT
GCCCTTGGAAAAGCGCCAGATTGCGTTGTTATTGTAGCAACGATTCGCGCACTGAAAATGCACGGTGGCGCTTTGAAAAC
CGAGCTTAGCGAAGAAAATGTGGATGCGCTAGCTAAAGGTTTTACTAATTTACAAAAACATACGGAATCTATTCAAACAT
TTGGTATTCCTTATGTTGTAGCCATTAATAAATTCATTACCGATTCTGACGCAGAAGTAGCGAAATTAGAAGCACTTTGC
GAAGAACACGGCATTCCTTTCTCTCTGACAGAAGTTTGGGAAAAAGGCGGCGACGGTGGCCTTGAACTCGCGGATAAAGT
CATTGCGGCTGTTGAAAGTGGAGAAGCGGACTACAAACGCATTTATGATGATGCGTGGTCGATAGAAGAAAAACTAGAAG
CGATTGTGACGAAGGTTTACGGTGGTATTGGTGTGGAACTTTCCAGCAAGGCGCAGAAACAAATCGTTGAATTCAAAAAA
TATGGTTGGGACCGCTATCCGATTTGTATGGCGAAAACCCAATATTCCTTATCGGATGACCCAACATTACTTGGACGCCC
AACTGATTTTGTTATTCACATTCGCGAATTCATTCCAAAACTTGGTGCTGGTTTTGTCGTTGCTTTAACAGGCGATGTAA
TGACGATGCCAGGTTTACCGAAAAAACCAGCGGCACTTAATATGGATGTCGATGAAAATGGGAATGCACAAGGTTTATTT
TAA

Upstream 100 bases:

>100_bases
AAATGGTGTTACATCGCTTGGTGTCGCGCTTTTTTGATGCACTAAAGAAGCCAAAACATCTTAATTCTTTGTTACAATAT
ACATATTCGGAGGGGATATC

Downstream 100 bases:

>100_bases
AAGTAAAAGTTCCAAAAGTGGAAGAGCCGCTTTTGGAACTTTTTTCATCTTAAGCAATTGCTATGTTCTATGTTTTCAGC
TAGAATAGATAAGGACGAAC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MSNKVKSDIEIASKAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEPGKLVLVTAINPTPAGEGKSTVTV
GLGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQVIPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLDI
DGRRIVWKRVVDLNDRALRKVVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVG
EMGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALRLGEYVVTEAGFGADLGAEKFLDIKVP
ALGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKGFTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEALC
EEHGIPFSLTEVWEKGGDGGLELADKVIAAVESGEADYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKK
YGWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLPKKPAALNMDVDENGNAQGLF

Sequences:

>Translated_560_residues
MSNKVKSDIEIASKAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEPGKLVLVTAINPTPAGEGKSTVTV
GLGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQVIPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLDI
DGRRIVWKRVVDLNDRALRKVVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVG
EMGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALRLGEYVVTEAGFGADLGAEKFLDIKVP
ALGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKGFTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEALC
EEHGIPFSLTEVWEKGGDGGLELADKVIAAVESGEADYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKK
YGWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLPKKPAALNMDVDENGNAQGLF
>Mature_559_residues
SNKVKSDIEIASKAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEPGKLVLVTAINPTPAGEGKSTVTVG
LGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQVIPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLDID
GRRIVWKRVVDLNDRALRKVVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVGE
MGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALRLGEYVVTEAGFGADLGAEKFLDIKVPA
LGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKGFTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEALCE
EHGIPFSLTEVWEKGGDGGLELADKVIAAVESGEADYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKKY
GWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLPKKPAALNMDVDENGNAQGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=45.016077170418, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI222136639, Length=626, Percent_Identity=43.1309904153355, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=614, Percent_Identity=42.671009771987, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17568739, Length=614, Percent_Identity=42.671009771987, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319558, Length=637, Percent_Identity=45.0549450549451, Blast_Score=475, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.2907348242812, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=41.3848631239936, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=41.3848631239936, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=41.3848631239936, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=41.3848631239936, Blast_Score=447, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60127; Mature: 59996

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKVKSDIEIASKAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEPGKL
CCCCCCCCHHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHHHEEECHHHHHHHCCCCCCCE
VLVTAINPTPAGEGKSTVTVGLGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQV
EEEEEECCCCCCCCCCEEEEECCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
IPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLDIDGRRIVWKRVVDLNDRALRK
EEECCCEEEEECCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCHHHHHH
VVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVG
HHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEC
EMGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALRLGEYVV
CCCCCHHHHHHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHE
TEAGFGADLGAEKFLDIKVPALGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKG
ECCCCCCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCHHCCCCCCCHHHHHHHH
FTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEALCEEHGIPFSLTEVWEKGGDGG
HHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHCCCCCC
LELADKVIAAVESGEADYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
YGWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLP
CCCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCCC
KKPAALNMDVDENGNAQGLF
CCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SNKVKSDIEIASKAEILPVTTIAEHLGLDADALELYGKYKAKLSYDTIHSLKDKEPGKL
CCCCCCCHHHHCCCCEEEHHHHHHHHCCCHHHHHHHHHHHEEECHHHHHHHCCCCCCCE
VLVTAINPTPAGEGKSTVTVGLGDALSKKDKKTVIALREPSLGPTMGIKGGATGGGYAQV
EEEEEECCCCCCCCCCEEEEECCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
IPMEDINLHFTGDFHAITAANNALSAFIDNHMQQGNDLDIDGRRIVWKRVVDLNDRALRK
EEECCCEEEEECCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCCHHHHHH
VVVGLGGPIQGVPREDGFDITVASEIMAIICLASDLKDLKKRLSEIVIGYNYKKEPITVG
HHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEC
EMGYEGALTLLLKDALKPNLVQTLEHTPAIVHGGPFANIAHGCNSVSATSTALRLGEYVV
CCCCCHHHHHHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHE
TEAGFGADLGAEKFLDIKVPALGKAPDCVVIVATIRALKMHGGALKTELSEENVDALAKG
ECCCCCCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCHHCCCCCCCHHHHHHHH
FTNLQKHTESIQTFGIPYVVAINKFITDSDAEVAKLEALCEEHGIPFSLTEVWEKGGDGG
HHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHCCCCCC
LELADKVIAAVESGEADYKRIYDDAWSIEEKLEAIVTKVYGGIGVELSSKAQKQIVEFKK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
YGWDRYPICMAKTQYSLSDDPTLLGRPTDFVIHIREFIPKLGAGFVVALTGDVMTMPGLP
CCCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCCC
KKPAALNMDVDENGNAQGLF
CCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]