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The map label for this gene is rnc

Identifier: 226224408

GI number: 226224408

Start: 1866411

End: 1867100

Strand: Reverse

Name: rnc

Synonym: Lm4b_01821

Alternate gene names: 226224408

Gene position: 1867100-1866411 (Counterclockwise)

Preceding gene: 226224409

Following gene: 226224407

Centisome position: 64.1

GC content: 39.42

Gene sequence:

>690_bases
ATGAATCAATGGGAAGAGTTACAAGAAAGCGTTGGATTCGATTTTAAAGATGTTGAATTATTAAAACAAGCATTCACACA
TTCCTCATATGTGAACGAACACCGCCGGGAAAATGTGAAAGATAATGAACGCTTAGAATTTCTTGGTGATGCAGTCCTTG
AACTCACTGTATCGAATTATCTATTTAACAAATATCCAGATATGGCAGAAGGACACATGACAAAAATGCGCGCAGCAATT
GTTTGTGAGCCTTCTTTAGTCGAGTTTGCAGAAGCAGTACATTTTTCTAAATACGTACGACTTGGTAAAGGGGAAGAAAA
AGCCGGTGGAAGAACTCGTCCGGCACTTCTGGCGGATGTATTTGAATCTTTTATCGGCGCGCTTTATTTAGATAATGGGA
TTGACAAAGTTGTGACATTTTTAGAACGTGTTATTTTTCCAAAAATTGATGCAGGGGCATATCTACAAACAGTGGATTAT
AAAACGCAACTGCAAGAAATTGTTCAACGGGACCGTGATGTCTTGATCGAATATGATATCCTTGGCGAAACAGGACCAGC
GCACAATAAAGCATTCGATGCCCAAGTAATTGTTAACGGACAAGTACTCGGAAAAGGCAGCGGCAGAACAAAAAAACAAG
CAGAACAAAGTGCGGCACAATTTGCTATAAACCAACTAACACACAGATAA

Upstream 100 bases:

>100_bases
TTTCAAGGTCACGAGATTTTGTTGGTTCATTTTCTAAGCAGCTTTTTGCTAGTGGCTGTTTAGAAAATGAACTTGCTTAT
TAAAGAGAGGAGCAAGTGAA

Downstream 100 bases:

>100_bases
ACAAAAATGGAGGTGTCCGGACATGTTATTAAAACGATTAGAAATGAATGGCTTTAAATCCTTTGCTGACAAAGTTGCGA
TAGATTTCGTGCCCGGCATG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNYLFNKYPDMAEGHMTKMRAAI
VCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDY
KTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR

Sequences:

>Translated_229_residues
MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNYLFNKYPDMAEGHMTKMRAAI
VCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDY
KTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR
>Mature_229_residues
MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNYLFNKYPDMAEGHMTKMRAAI
VCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADVFESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDY
KTQLQEIVQRDRDVLIEYDILGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=32.5991189427313, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=32.8947368421053, Blast_Score=118, Evalue=4e-27,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=36.9668246445498, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=30.672268907563, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=30.672268907563, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17552834, Length=180, Percent_Identity=30, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323895, Length=213, Percent_Identity=30.5164319248826, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=28.695652173913, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25906; Mature: 25906

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNY
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LFNKYPDMAEGHMTKMRAAIVCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADV
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
FESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDYKTQLQEIVQRDRDVLIEYDI
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEEE
LGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR
CCCCCCCCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQWEELQESVGFDFKDVELLKQAFTHSSYVNEHRRENVKDNERLEFLGDAVLELTVSNY
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LFNKYPDMAEGHMTKMRAAIVCEPSLVEFAEAVHFSKYVRLGKGEEKAGGRTRPALLADV
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
FESFIGALYLDNGIDKVVTFLERVIFPKIDAGAYLQTVDYKTQLQEIVQRDRDVLIEYDI
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEEE
LGETGPAHNKAFDAQVIVNGQVLGKGSGRTKKQAEQSAAQFAINQLTHR
CCCCCCCCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]