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The map label for this gene is clpP3 [H]

Identifier: 226223740

GI number: 226223740

Start: 1154789

End: 1155361

Strand: Reverse

Name: clpP3 [H]

Synonym: Lm4b_01144

Alternate gene names: 226223740

Gene position: 1155361-1154789 (Counterclockwise)

Preceding gene: 226223741

Following gene: 226223739

Centisome position: 39.67

GC content: 38.92

Gene sequence:

>573_bases
ATGGCAGAGAATAAAAATAATGAAAATATCACAAACATCCTTACCCAAAAATTGATTGATACACGAACGGTGTTAATTTA
CGGGGAAATCAATCAGGAGTTAGCCGAAGACGTTTCTAAGCAGCTTTTACTACTTGAATCGATCAGTGACGAACCAATTA
CGATTTTTGTAAATAGCCAAGGTGGTCATGTTGAAGCTGGCGATACGATTCACGATATGATTAAATTCATTAAGCCTACA
GTGAAAGTCGTTGGAACTGGATGGGTTGCAAGCGCTGGTATTACTATTTATCTAGCCGCTGACAAAGAAAACCGTTATAG
CCTACCTAACACTCGCTATATGATTCATCAACCAGCTGGCGGTGTCCAAGGTCAAAGCACAGAAATCGAAATCGAAGCAA
AAGAAATTATACGAATGCGCGAAAGAATTAATCGCCTAATCGCCGAAGCAACAGGTCAATCGTACGAAAAAATCTCCAAA
GATACAGACCGCAACTTCTGGCTTTCTGTAAATGAAGCAAAAGATTACGGCATCGTAAATGAAATCATTCAAAATCGTGA
CGGAATAAAATAA

Upstream 100 bases:

>100_bases
CGTTTTCTTTTTTGCATTCAAAATGTTTGACCATTTTCGACCATTATGATAAGATACCTGTATTACCAATAAACTAAGGC
TTTTTAAGGAGGAATTTTTC

Downstream 100 bases:

>100_bases
CATAAAAAGGTTCACTTACAAAATGAAGTGAACCTTTTTATTTCTTTAAAATGGAGGAATTACCATGGAATTAACGAAAG
AAAATTTTCAAAAACTTGAC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 3 [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAENKNNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISDEPITIFVNSQGGHVEAGDTIHDMIKFIKPT
VKVVGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPAGGVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEKISK
DTDRNFWLSVNEAKDYGIVNEIIQNRDGIK

Sequences:

>Translated_190_residues
MAENKNNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISDEPITIFVNSQGGHVEAGDTIHDMIKFIKPT
VKVVGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPAGGVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEKISK
DTDRNFWLSVNEAKDYGIVNEIIQNRDGIK
>Mature_189_residues
AENKNNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISDEPITIFVNSQGGHVEAGDTIHDMIKFIKPTV
KVVGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPAGGVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEKISKD
TDRNFWLSVNEAKDYGIVNEIIQNRDGIK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=168, Percent_Identity=36.9047619047619, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=42.4418604651163, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17538017, Length=181, Percent_Identity=36.4640883977901, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20129427, Length=170, Percent_Identity=35.2941176470588, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21362; Mature: 21231

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENKNNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISDEPITIFVNSQ
CCCCCCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GGHVEAGDTIHDMIKFIKPTVKVVGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPAG
CCEEECCCHHHHHHHHHHHHHHEEECCEEECCCEEEEEEECCCCCCCCCCCEEEEECCCC
GVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEKISKDTDRNFWLSVNEAKDYGIVN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCCHHHH
EIIQNRDGIK
HHHHCCCCCC
>Mature Secondary Structure 
AENKNNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISDEPITIFVNSQ
CCCCCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GGHVEAGDTIHDMIKFIKPTVKVVGTGWVASAGITIYLAADKENRYSLPNTRYMIHQPAG
CCEEECCCHHHHHHHHHHHHHHEEECCEEECCCEEEEEEECCCCCCCCCCCEEEEECCCC
GVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEKISKDTDRNFWLSVNEAKDYGIVN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCCHHHH
EIIQNRDGIK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA