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The map label for this gene is moeA [H]

Identifier: 226223660

GI number: 226223660

Start: 1072500

End: 1073723

Strand: Direct

Name: moeA [H]

Synonym: Lm4b_01062

Alternate gene names: 226223660

Gene position: 1072500-1073723 (Clockwise)

Preceding gene: 226223659

Following gene: 226223661

Centisome position: 36.82

GC content: 39.71

Gene sequence:

>1224_bases
ATGATTGAAAAAAGAAATACCATTAGAATGGAACAAGCGAGAGAGATATTATGTAATCAAATAACGCATCTTCCAGTAGA
AAAGAAATGTGTGACAGAGACGTTAAACCAAGTATTACAAGAACCTATTTTCGCGCCGTTTCCTGCTCCCTATTTTAGGC
GCTCTGGTTATGATGGCTTTGCGATTTCTGAGGAGGATGACGAGAATTATCCTATCACTTTGCACGTTGTAGCAGAAGTT
CCGTGTGGGGAAACATACGATAAACTGCTAAAACCTGGTGAAACCGTCCGAATAATGACTGGAGCAAAAGTGCCAGATAA
TGCCTCGAAAATTATTATGCTCGAACAATCAAGAGAAGCGGATAACGAGCATGAAATCGTACTTATAAATACACAAAAAT
CTACTAACATTACAGAAATCGGTACGGAGTTCGCCAAAGGAGATTTGCTGTTAGATCGTGGACACATTTTAAATGCCGGT
TCGATAAGTTTACTGTCATCCTTTGGAATTCAAGAAGTACAAGTCATCAGAAAGCCAAAAGTAGCTATTTTATCCACAGG
TAGTGAACTTGTTCCTGCTGGAAATCCACTTCCAGATGGCAAAATTTTTAATAGTAATCAACCATTACTGGAGAATTTAC
TAAAAGTACATCATGCCGAGATTTGCGCGGCCGAACAATTACCTGATAATTATGAGGATACGAAAAAGCGATTACTAGAA
TTGACTCAAATAGCAGACTTGATAATCACTACAGGTGGTGTTTCTATAGGGGACTTTGACTATATGGCTGATATTGCAAA
AAAAGAGGCAGAATTACTTTTTAATAAAATTCAAATGCGACCGGGCAGTCCGACAACAGGGATGTGGTTGGACAACACGC
TTATCATCGCACTTTCTGGTAATCCAGGGGCATGCTTTACAGGTTTTTACTTATTCGTAGAACCGGTATTAGCTACCTTA
ATGGGGAAAGATACAACTGAGACGACCAAAGTCCGTGCAAAAATGGCGAGCGATTACACTAAAAATAATGGCTATGATCG
TTTTTTACGAGGAACCTATCGTTTGTCTGACGAAGGGGAATATTTGGTTGAGTTGGTAGGAAGCGATATGTCGAGTGCGC
TAGGAAACCTCCATTTAACCACCTGTTTATTCAAAATCCCTCGCGGTAAAGTTGGAAAATTAAAAGGAGAAGAGGTCGAA
GCATGGCTACTATCCTCCAAATAA

Upstream 100 bases:

>100_bases
AACTAAGGAGAAGTCGCTTTACTTTTTAAAACAAGCAAACTCCTGTATATTGGTACTAAAGAAAACGCATACATTATTTA
GGAAAGGGAAGTGCGCCCAG

Downstream 100 bases:

>100_bases
TCGGCTTTAAAAATAGCGGGAAGACAACTTTACTAAATGCACTAATTCGAGCTAGTCGGAAGGAAAACTACACAGTATCT
GCCATCAAACATGATGCACA

Product: molybdopterin biosynthesis protein moeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MIEKRNTIRMEQAREILCNQITHLPVEKKCVTETLNQVLQEPIFAPFPAPYFRRSGYDGFAISEEDDENYPITLHVVAEV
PCGETYDKLLKPGETVRIMTGAKVPDNASKIIMLEQSREADNEHEIVLINTQKSTNITEIGTEFAKGDLLLDRGHILNAG
SISLLSSFGIQEVQVIRKPKVAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKKRLLE
LTQIADLIITTGGVSIGDFDYMADIAKKEAELLFNKIQMRPGSPTTGMWLDNTLIIALSGNPGACFTGFYLFVEPVLATL
MGKDTTETTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVELVGSDMSSALGNLHLTTCLFKIPRGKVGKLKGEEVE
AWLLSSK

Sequences:

>Translated_407_residues
MIEKRNTIRMEQAREILCNQITHLPVEKKCVTETLNQVLQEPIFAPFPAPYFRRSGYDGFAISEEDDENYPITLHVVAEV
PCGETYDKLLKPGETVRIMTGAKVPDNASKIIMLEQSREADNEHEIVLINTQKSTNITEIGTEFAKGDLLLDRGHILNAG
SISLLSSFGIQEVQVIRKPKVAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKKRLLE
LTQIADLIITTGGVSIGDFDYMADIAKKEAELLFNKIQMRPGSPTTGMWLDNTLIIALSGNPGACFTGFYLFVEPVLATL
MGKDTTETTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVELVGSDMSSALGNLHLTTCLFKIPRGKVGKLKGEEVE
AWLLSSK
>Mature_407_residues
MIEKRNTIRMEQAREILCNQITHLPVEKKCVTETLNQVLQEPIFAPFPAPYFRRSGYDGFAISEEDDENYPITLHVVAEV
PCGETYDKLLKPGETVRIMTGAKVPDNASKIIMLEQSREADNEHEIVLINTQKSTNITEIGTEFAKGDLLLDRGHILNAG
SISLLSSFGIQEVQVIRKPKVAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKKRLLE
LTQIADLIITTGGVSIGDFDYMADIAKKEAELLFNKIQMRPGSPTTGMWLDNTLIIALSGNPGACFTGFYLFVEPVLATL
MGKDTTETTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVELVGSDMSSALGNLHLTTCLFKIPRGKVGKLKGEEVE
AWLLSSK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=368, Percent_Identity=29.8913043478261, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI10880983, Length=368, Percent_Identity=29.8913043478261, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1787049, Length=386, Percent_Identity=28.7564766839378, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=421, Percent_Identity=28.0285035629454, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=355, Percent_Identity=27.0422535211268, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136978, Length=369, Percent_Identity=28.9972899728997, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24638841, Length=369, Percent_Identity=28.9972899728997, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45084; Mature: 45084

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKRNTIRMEQAREILCNQITHLPVEKKCVTETLNQVLQEPIFAPFPAPYFRRSGYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
AISEEDDENYPITLHVVAEVPCGETYDKLLKPGETVRIMTGAKVPDNASKIIMLEQSREA
EECCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCC
DNEHEIVLINTQKSTNITEIGTEFAKGDLLLDRGHILNAGSISLLSSFGIQEVQVIRKPK
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCEECCCHHHHHHHCCHHHHHHHCCCC
VAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKKRLLE
EEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LTQIADLIITTGGVSIGDFDYMADIAKKEAELLFNKIQMRPGSPTTGMWLDNTLIIALSG
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECC
NPGACFTGFYLFVEPVLATLMGKDTTETTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGE
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEECCCCH
YLVELVGSDMSSALGNLHLTTCLFKIPRGKVGKLKGEEVEAWLLSSK
HHHHHHCCHHHHHHCCHHHHHHHEECCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIEKRNTIRMEQAREILCNQITHLPVEKKCVTETLNQVLQEPIFAPFPAPYFRRSGYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
AISEEDDENYPITLHVVAEVPCGETYDKLLKPGETVRIMTGAKVPDNASKIIMLEQSREA
EECCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCC
DNEHEIVLINTQKSTNITEIGTEFAKGDLLLDRGHILNAGSISLLSSFGIQEVQVIRKPK
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCEECCCHHHHHHHCCHHHHHHHCCCC
VAILSTGSELVPAGNPLPDGKIFNSNQPLLENLLKVHHAEICAAEQLPDNYEDTKKRLLE
EEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LTQIADLIITTGGVSIGDFDYMADIAKKEAELLFNKIQMRPGSPTTGMWLDNTLIIALSG
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECC
NPGACFTGFYLFVEPVLATLMGKDTTETTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGE
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEECCCCH
YLVELVGSDMSSALGNLHLTTCLFKIPRGKVGKLKGEEVEAWLLSSK
HHHHHHCCHHHHHHCCHHHHHHHEECCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA