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The map label for this gene is gpo [H]

Identifier: 226223601

GI number: 226223601

Start: 1015601

End: 1016080

Strand: Direct

Name: gpo [H]

Synonym: Lm4b_01003

Alternate gene names: 226223601

Gene position: 1015601-1016080 (Clockwise)

Preceding gene: 226223600

Following gene: 226223602

Centisome position: 34.87

GC content: 35.0

Gene sequence:

>480_bases
ATGAATGTCCATGATTTTTCTGAAAAAGCAATGAATGGCAAAGAAATAGCTTTAAGTGATTATAAAGGTAAGGTATTACT
CATCGTGAATACTGCGAGTAAATGTGGCTTAACACCCCAATTAGAAGGTCTCGAAGCAATGTATAAAAAATTGGGTGGCG
CTAATTTTGAAATCCTCGGTTTCCCGTGTAACCAGTTTTTGCGACAAGATCCTGGCAGTGATGAGGAAATTTTAGAATTT
TGCCAAATGAATTATGGTGTGACTTTCCAAATGTTTTCCAAAATTAAAGTAAAAGGCAAAGATGCCAGCCCACTTTATAA
ATATTTAACCGAACAAACGGGTGGTAAAAAAGTAGAATGGAACTTTGCGAAATTCTTAATTGATGAAAATGGAGAAGTTG
TTGAACGTTTCCCATCTAAAATGAAACCAGCAGATTTTGAGGATAAAGTGGAAGCACTTGTTGCGAAAGTAAATAATTAA

Upstream 100 bases:

>100_bases
CCATGCATATGAACGCACACACCGCGATTCACTTTACCATACAGAAAAATTAGTTTATGCATATTTATTTTCAAATATAT
TGAAATAGGAGGAATCCCAT

Downstream 100 bases:

>100_bases
GGAAAACTCGGTAGTGCTATTATAGTACTACCGAGTTTTTTGCATCTTAGTTAGTTAAAAATGCATGTTACTGAAATCAG
CTTGTAGTTTTTGACATGGC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MNVHDFSEKAMNGKEIALSDYKGKVLLIVNTASKCGLTPQLEGLEAMYKKLGGANFEILGFPCNQFLRQDPGSDEEILEF
CQMNYGVTFQMFSKIKVKGKDASPLYKYLTEQTGGKKVEWNFAKFLIDENGEVVERFPSKMKPADFEDKVEALVAKVNN

Sequences:

>Translated_159_residues
MNVHDFSEKAMNGKEIALSDYKGKVLLIVNTASKCGLTPQLEGLEAMYKKLGGANFEILGFPCNQFLRQDPGSDEEILEF
CQMNYGVTFQMFSKIKVKGKDASPLYKYLTEQTGGKKVEWNFAKFLIDENGEVVERFPSKMKPADFEDKVEALVAKVNN
>Mature_159_residues
MNVHDFSEKAMNGKEIALSDYKGKVLLIVNTASKCGLTPQLEGLEAMYKKLGGANFEILGFPCNQFLRQDPGSDEEILEF
CQMNYGVTFQMFSKIKVKGKDASPLYKYLTEQTGGKKVEWNFAKFLIDENGEVVERFPSKMKPADFEDKVEALVAKVNN

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=157, Percent_Identity=41.4012738853503, Blast_Score=130, Evalue=6e-31,
Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.1612903225806, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI90903240, Length=151, Percent_Identity=45.6953642384106, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI192455698, Length=155, Percent_Identity=37.4193548387097, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI90903238, Length=133, Percent_Identity=45.1127819548872, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI4557629, Length=163, Percent_Identity=31.9018404907975, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI6006001, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI32967607, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI33186887, Length=160, Percent_Identity=28.75, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788003, Length=160, Percent_Identity=45.625, Blast_Score=136, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17506887, Length=164, Percent_Identity=43.2926829268293, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71993584, Length=159, Percent_Identity=35.8490566037736, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=40.5063291139241, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193210707, Length=160, Percent_Identity=32.5, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17550320, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193209493, Length=185, Percent_Identity=29.1891891891892, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71993573, Length=98, Percent_Identity=33.6734693877551, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=50.9554140127389, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322228, Length=149, Percent_Identity=50.3355704697987, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322826, Length=155, Percent_Identity=40, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=38.6075949367089, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24656772, Length=159, Percent_Identity=39.622641509434, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656767, Length=159, Percent_Identity=39.622641509434, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656777, Length=159, Percent_Identity=39.622641509434, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17892; Mature: 17892

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHDFSEKAMNGKEIALSDYKGKVLLIVNTASKCGLTPQLEGLEAMYKKLGGANFEILG
CCCCCCHHHHCCCCEEEEECCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHCCCCEEEEE
FPCNQFLRQDPGSDEEILEFCQMNYGVTFQMFSKIKVKGKDASPLYKYLTEQTGGKKVEW
CCHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEE
NFAKFLIDENGEVVERFPSKMKPADFEDKVEALVAKVNN
EHEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVHDFSEKAMNGKEIALSDYKGKVLLIVNTASKCGLTPQLEGLEAMYKKLGGANFEILG
CCCCCCHHHHCCCCEEEEECCCCEEEEEEECCHHCCCCCCHHHHHHHHHHHCCCCEEEEE
FPCNQFLRQDPGSDEEILEFCQMNYGVTFQMFSKIKVKGKDASPLYKYLTEQTGGKKVEW
CCHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEE
NFAKFLIDENGEVVERFPSKMKPADFEDKVEALVAKVNN
EHEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]