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The map label for this gene is dltA

Identifier: 226223592

GI number: 226223592

Start: 1006094

End: 1007626

Strand: Reverse

Name: dltA

Synonym: Lm4b_00994

Alternate gene names: 226223592

Gene position: 1007626-1006094 (Counterclockwise)

Preceding gene: 226223594

Following gene: 226223591

Centisome position: 34.59

GC content: 37.7

Gene sequence:

>1533_bases
ATGACAACGAGTATCATAGAAAGAATTGATGCATGGGCAGAGAAGACACCGGATTTCCCTTGCTATGAATATGCTGGAAC
ACGTCTTTCCTATAAAGAACTAAAACGACAATCTGATGCATTCGGCTCTTTTCTACTAAAAACCCTGAATACTGACAAAG
AAAAACCTATTATCGTTTACGGACATATGTCTCCCCTAATGCTAGTTGCATTTTTAGGCTCTATCAAATCAGGTCGAGCT
TATGTACCAGTAGATGTTTCTATGCCAGTTGAACGTATAGAACAAATTAAAAAAGCAGCTGATCCTTCTTTGTTTATTTG
TACAGAAGAGCTACCTAGTAACCTTACTATTACTGGTTGTCCGGTACTAACACAAGATCAGCTAATGGACGCCTTAGAGA
AACATTTCGGAGAAGTTCCAGATAAAGAAGCATGTGTAAAAAATGATGATAACTACTATATTATTTACACATCCGGAAGT
ACAGGAAATCCTAAAGGGGTTCAAATCAGTCAAAACAATCTAGTAAGTTTTAGTAACTGGATATTACAAGACTTTTCTTT
AAGCCAAGGATTGCGTTTCTTAAACCAAGCACCCTTTTCCTTCGATCTATCCGTTATGGATTTATATCCAAGTTTACTAT
CGGGTGGAACGCTTGTACCTCTTGATAAAACAATTACTGCGAATATGAAAGATTTATATCGTGAAATACCTGCTCAAAAC
TTGGATGTATGGGTTTCTACTCCTTCTTTTGCTGATTTGTGCTTACTAGACGATAACTTTAACCAAGAAAATAACCCTGG
CTTAATTCATTTCTTATTCTGTGGTGAAGTACTTGCCAAGAAAACAGCAAGCGAATTGCTGAACCGTTTCCCAGATGCAG
TTATTTACAACACATACGGACCTACAGAAGCAACCGTGGCTGTCACTCAAGTAAAAGTAACTCGAGAGGTTATCGATGCT
TATCCAAGCTTACCACTTGGCGTTATTAAACCAGATATGCGTTTACACATCGTTGACCAAGAAACTGGTGAGGTTCTTCC
AGAAGGCGAAAAAGGAGAAATTGTCCTGATTGGTGCTAGCGTTTCTAAAGGTTACTTAAATGAACCTGAAAAAACAGACC
AAGTATTCTTCGACTATAAAGGTTATCAAGCTTATCGCACAGGAGACTCTGGCATTATCAAAGACGGTTATCTGTTCTTC
CAAGGACGTCTTGACTTCCAAATTAAACTGCATGGTTATCGCATCGAATTAGAAGATATCGAAAACAACCTAAAAAAAGT
AAGTTACATTCAAAACTGCGCTATTATTCCTAAAATGAAAGATGAAAAGGTAGATATGTTGGTCGCACAGGTCATCCCTA
CTAACCATGATTTCGAAAAAGAATACCAGCTAAGTGCAGCAATAAAAAATGAACTGAAAGAATTTATGCCAGCATACATG
ATCCCAAGAAAATGGATTTACAAAACGGAATTCCCGTTAACTATGAATGGCAAAATCGATCGCAAGGCGCTTAATAGCGA
GGTTAACAAGTGA

Upstream 100 bases:

>100_bases
ATTGCTTTGGTTTTATGGTTTCAAAAACCCTGAAGGTGCGAAATTCATTTACAATGAATTCTAAAAGAAGAAAGGACTGT
TAAAAATGGGAATATCAATA

Downstream 100 bases:

>100_bases
GTTTACCATACGGCACAATCCTTTATTTTGGAGTACTTGTACTATTTTTGATTCCTATCATAGTAGCTGGTTTGTTAGGA
AAAAGATTACCGATTTATAA

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKTLNTDKEKPIIVYGHMSPLMLVAFLGSIKSGRA
YVPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGCPVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGS
TGNPKGVQISQNNLVSFSNWILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQN
LDVWVSTPSFADLCLLDDNFNQENNPGLIHFLFCGEVLAKKTASELLNRFPDAVIYNTYGPTEATVAVTQVKVTREVIDA
YPSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGASVSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFF
QGRLDFQIKLHGYRIELEDIENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYM
IPRKWIYKTEFPLTMNGKIDRKALNSEVNK

Sequences:

>Translated_510_residues
MTTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKTLNTDKEKPIIVYGHMSPLMLVAFLGSIKSGRA
YVPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGCPVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGS
TGNPKGVQISQNNLVSFSNWILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQN
LDVWVSTPSFADLCLLDDNFNQENNPGLIHFLFCGEVLAKKTASELLNRFPDAVIYNTYGPTEATVAVTQVKVTREVIDA
YPSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGASVSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFF
QGRLDFQIKLHGYRIELEDIENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYM
IPRKWIYKTEFPLTMNGKIDRKALNSEVNK
>Mature_509_residues
TTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKTLNTDKEKPIIVYGHMSPLMLVAFLGSIKSGRAY
VPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGCPVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGST
GNPKGVQISQNNLVSFSNWILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQNL
DVWVSTPSFADLCLLDDNFNQENNPGLIHFLFCGEVLAKKTASELLNRFPDAVIYNTYGPTEATVAVTQVKVTREVIDAY
PSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGASVSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFFQ
GRLDFQIKLHGYRIELEDIENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYMI
PRKWIYKTEFPLTMNGKIDRKALNSEVNK

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=474, Percent_Identity=24.4725738396624, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI187761343, Length=474, Percent_Identity=24.4725738396624, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38505220, Length=538, Percent_Identity=22.8624535315985, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI45580730, Length=374, Percent_Identity=24.0641711229947, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI115511026, Length=542, Percent_Identity=22.6937269372694, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI122937307, Length=539, Percent_Identity=23.5621521335807, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156151445, Length=533, Percent_Identity=23.827392120075, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI42544132, Length=540, Percent_Identity=23.1481481481481, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI157311624, Length=508, Percent_Identity=23.4251968503937, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI157311622, Length=508, Percent_Identity=23.4251968503937, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=23.1827111984283, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1786801, Length=513, Percent_Identity=28.2651072124756, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786810, Length=504, Percent_Identity=22.8174603174603, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788107, Length=553, Percent_Identity=21.880650994575, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=504, Percent_Identity=24.0079365079365, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17556356, Length=487, Percent_Identity=27.5154004106776, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=486, Percent_Identity=22.4279835390947, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=448, Percent_Identity=24.5535714285714, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17557194, Length=395, Percent_Identity=26.0759493670886, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=383, Percent_Identity=24.8041775456919, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=376, Percent_Identity=26.063829787234, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=372, Percent_Identity=23.1182795698925, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=560, Percent_Identity=22.8571428571429, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319699, Length=368, Percent_Identity=25.2717391304348, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648676, Length=507, Percent_Identity=26.232741617357, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21355181, Length=394, Percent_Identity=26.1421319796954, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581924, Length=540, Percent_Identity=22.7777777777778, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 57582; Mature: 57450

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKTLNTDKEKPIIVY
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GHMSPLMLVAFLGSIKSGRAYVPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGC
ECCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHCCCCEEEECC
PVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGSTGNPKGVQISQNNLVSFSNW
CCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCEEHHHH
ILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQN
HHHHHCHHHHHHHHHCCCCEECCHHHHHHHHHHCCCEEEECCCCEECCHHHHHHHCCCCC
LDVWVSTPSFADLCLLDDNFNQENNPGLIHFLFCGEVLAKKTASELLNRFPDAVIYNTYG
CEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCC
PTEATVAVTQVKVTREVIDAYPSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGAS
CCCCEEEEEHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECC
VSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFFQGRLDFQIKLHGYRIELEDI
CCCCCCCCCCCCCEEEEEECCEEEEECCCCCEEECCEEEEEEEEEEEEEEEEEEEEHHHH
ENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYM
HHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRKWIYKTEFPLTMNGKIDRKALNSEVNK
CCCHHEEEECCCEEECCCCHHHHHHHCCCC
>Mature Secondary Structure 
TTSIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKTLNTDKEKPIIVY
CHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GHMSPLMLVAFLGSIKSGRAYVPVDVSMPVERIEQIKKAADPSLFICTEELPSNLTITGC
ECCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHCCCCEEEECC
PVLTQDQLMDALEKHFGEVPDKEACVKNDDNYYIIYTSGSTGNPKGVQISQNNLVSFSNW
CCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCEEHHHH
ILQDFSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQN
HHHHHCHHHHHHHHHCCCCEECCHHHHHHHHHHCCCEEEECCCCEECCHHHHHHHCCCCC
LDVWVSTPSFADLCLLDDNFNQENNPGLIHFLFCGEVLAKKTASELLNRFPDAVIYNTYG
CEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCC
PTEATVAVTQVKVTREVIDAYPSLPLGVIKPDMRLHIVDQETGEVLPEGEKGEIVLIGAS
CCCCEEEEEHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEEECC
VSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDGYLFFQGRLDFQIKLHGYRIELEDI
CCCCCCCCCCCCCEEEEEECCEEEEECCCCCEEECCEEEEEEEEEEEEEEEEEEEEHHHH
ENNLKKVSYIQNCAIIPKMKDEKVDMLVAQVIPTNHDFEKEYQLSAAIKNELKEFMPAYM
HHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IPRKWIYKTEFPLTMNGKIDRKALNSEVNK
CCCHHEEEECCCEEECCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]