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The map label for this gene is gmuR [H]

Identifier: 226223523

GI number: 226223523

Start: 940225

End: 940938

Strand: Direct

Name: gmuR [H]

Synonym: Lm4b_00922

Alternate gene names: 226223523

Gene position: 940225-940938 (Clockwise)

Preceding gene: 226223522

Following gene: 226223524

Centisome position: 32.28

GC content: 39.92

Gene sequence:

>714_bases
TTGGTTAAGTATGAATTGATTGCAGCAGATATCCGCGAAAAAATAAACAACGGTACTTATCCACCAGAATCCATTCTTCC
TGATCAAGTGAGCTTGTGTAAAGCTTATGATTGTAGCAGAATGACAATAAAAAAAGCCTTTGACGTTTTAGCGCTTGAAG
GACTTGTTTACAGACAACGGGGTGCGGGGACTTTTGTCATGAAAAATGCCTTAGCTAATAAGCAAGATGCGAGTTTGCGG
GATTATGACGGTTTGACAAAAATGATGGGAGACAACCGAATCTCGAGTAAAATTATTGCATTCGATATTGCTTTCCCAGA
TGAAAAAACACAAGAACAACTTTTAATAAAAGCAGACCAGCCAGTGTACAAGTTGATTCGGTTACGGCTCTTGGACGGCG
CACCATATGTGTTAGAGCATACAACGATGCCGGCAGATTTAGTTCCTGGTTTAACGAAAGAAATTTTGCATCATTCGATT
TATGCATACTTACAAGATTCACTTGGACTCGTGCTAAGCGGTGCCTTTCGGAAAATTAATGCCGATAAGCCATCTGAATA
TGATCAAGAATATTTAGCGTGCGGGGAACACGACCCAGTTTTAGAAGTGGAGCAAGTAGTGTATTTGAAAGATGGTAGAC
CAGTGGAATATTCTAGATCAAGACATCGCTATGATACGAGAAGTTTTATTATGGTTGACCACCGAGAAAAGTAA

Upstream 100 bases:

>100_bases
CAGAGGCAGCTATCAAATAAGTTAAATTTTCCTTTTCGATATGCTATAATTTGACTAGAAATGGCTAGACATTTTTAATT
CAAGCGAAGGAGCGATCGAA

Downstream 100 bases:

>100_bases
AATAAAGTCAGCATGCCCGTAAAGCATAGCTGACTTTGTTTTATGGAGGTAAAAATGTATAAAAAACTTCCGATGAAAAA
AATGTAAATAAAATTAGAAA

Product: transcription regulator (GntR family)

Products: NA

Alternate protein names: Glucomannan utilization operon repressor; Glucomannan utilization protein R [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MVKYELIAADIREKINNGTYPPESILPDQVSLCKAYDCSRMTIKKAFDVLALEGLVYRQRGAGTFVMKNALANKQDASLR
DYDGLTKMMGDNRISSKIIAFDIAFPDEKTQEQLLIKADQPVYKLIRLRLLDGAPYVLEHTTMPADLVPGLTKEILHHSI
YAYLQDSLGLVLSGAFRKINADKPSEYDQEYLACGEHDPVLEVEQVVYLKDGRPVEYSRSRHRYDTRSFIMVDHREK

Sequences:

>Translated_237_residues
MVKYELIAADIREKINNGTYPPESILPDQVSLCKAYDCSRMTIKKAFDVLALEGLVYRQRGAGTFVMKNALANKQDASLR
DYDGLTKMMGDNRISSKIIAFDIAFPDEKTQEQLLIKADQPVYKLIRLRLLDGAPYVLEHTTMPADLVPGLTKEILHHSI
YAYLQDSLGLVLSGAFRKINADKPSEYDQEYLACGEHDPVLEVEQVVYLKDGRPVEYSRSRHRYDTRSFIMVDHREK
>Mature_237_residues
MVKYELIAADIREKINNGTYPPESILPDQVSLCKAYDCSRMTIKKAFDVLALEGLVYRQRGAGTFVMKNALANKQDASLR
DYDGLTKMMGDNRISSKIIAFDIAFPDEKTQEQLLIKADQPVYKLIRLRLLDGAPYVLEHTTMPADLVPGLTKEILHHSI
YAYLQDSLGLVLSGAFRKINADKPSEYDQEYLACGEHDPVLEVEQVVYLKDGRPVEYSRSRHRYDTRSFIMVDHREK

Specific function: Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=215, Percent_Identity=28.3720930232558, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=28.936170212766, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788418, Length=241, Percent_Identity=26.5560165975104, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082252, Length=232, Percent_Identity=22.4137931034483, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27035; Mature: 27035

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKYELIAADIREKINNGTYPPESILPDQVSLCKAYDCSRMTIKKAFDVLALEGLVYRQR
CCEEHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GAGTFVMKNALANKQDASLRDYDGLTKMMGDNRISSKIIAFDIAFPDEKTQEQLLIKADQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHEEEECCC
PVYKLIRLRLLDGAPYVLEHTTMPADLVPGLTKEILHHSIYAYLQDSLGLVLSGAFRKIN
HHHHHHHHHHCCCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADKPSEYDQEYLACGEHDPVLEVEQVVYLKDGRPVEYSRSRHRYDTRSFIMVDHREK
CCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCC
>Mature Secondary Structure
MVKYELIAADIREKINNGTYPPESILPDQVSLCKAYDCSRMTIKKAFDVLALEGLVYRQR
CCEEHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GAGTFVMKNALANKQDASLRDYDGLTKMMGDNRISSKIIAFDIAFPDEKTQEQLLIKADQ
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHEEEECCC
PVYKLIRLRLLDGAPYVLEHTTMPADLVPGLTKEILHHSIYAYLQDSLGLVLSGAFRKIN
HHHHHHHHHHCCCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADKPSEYDQEYLACGEHDPVLEVEQVVYLKDGRPVEYSRSRHRYDTRSFIMVDHREK
CCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377 [H]