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The map label for this gene is pgcA [H]

Identifier: 226223483

GI number: 226223483

Start: 904201

End: 905874

Strand: Direct

Name: pgcA [H]

Synonym: Lm4b_00881

Alternate gene names: 226223483

Gene position: 904201-905874 (Clockwise)

Preceding gene: 226223482

Following gene: 226223484

Centisome position: 31.04

GC content: 42.05

Gene sequence:

>1674_bases
ATGACTTGGCAACAACATTTGAACGCTTGGAAAAATGCCGATTTATCAGATGAGTGGCGCCGTGAATTACAACGAGTGGA
ACAGGAGCAGGAACGATTTGATGGTTATTTAACCTTTGGGACTGGCGGGATGCGCGGTAAAATGGGCGTTGGAACGAAGC
GCATCAATCTTTTTACCATTAGACGAGTAGCGAAAGGTTTGGGAGATTATGTTGTCGCGAATGGAGGAGCCGAAATGGGT
GTTGCGATTGCGTATGACTCGAGACATCATTCGGGTGCTTTTGCGCAGGAAACGGCAAAGGTCCTGGCGGCGCAGGGAGT
CAAAGTTTATTTATCCGATACGATTCGCCCAACACCAGCGCTATCTTTTTGCGTTCGAGAAAAGGGGGCATTTGCGGGCG
TTGTGATTACAGCAAGCCACAATCCTTCTATCTATAATGGTTTCAAAGTATATGATAAAAATGGCTGTCAAATCACATTG
GGTGTAGCGCAGGAAATTGCTGGCTATTTAGAAAACACAACGGATATCTTTACCATACCAGTGCGCGAATTACCCAATCC
ACTCGTTATGACGCTAGGAAAAGAAATGGACGATGCTTATTTAAAAGCTTTAACAGCAGTCGTTTCTCGCCCTGATTTGC
TTGCTGACTACGGTAATAAACTACAGATTTGCTACACACCGCTTCATGGAGCTGGAAAAGAACTTGTTATGCGTGGGCTT
TTGGAAAATGGATTTTCGGAAACGACCATGATTGCTGAGCAAAGTGAGCCTGACGGGGATTTTCCGACAGTGGTTTCGCC
TAATCCAGAAGAAGAAAACAGTTTTGAACTAGCCAAAAAGCAGGCGAAAGAAATACAAGCCGATATTATTTTGGCGACAG
ATCCGGATGCTGATAGGCTGGGGGTAGCTGTTTTAAACAAGCAAGCTACGTATCAAATTTTAACAGGGAATCAGCTAGGC
GCATTGCTTTTACAGTATATTTTAGAAGCCAAAACGTCGGTAACTCAGGCGGATACGATGATTAATACAATTGTTACTGG
GGACTTAGGTGGAAGAATCGCGCATGACTTTGGAATTAATCATATCCAGACGCTCACGGGTTTCAAATTTATCGGTGAAA
AAATAGCCGAAATGGAAGGCACGGAAAAAAACTTTCTTTTTGGATACGAGGAAAGTTACGGTTATTTAATCGCGCCATTT
GTTCGGGACAAGGACGCCGTTCAGGCAGCATTACTTACAGCAGAAATGGCCCTTTTCTATAAAAAAGAAGGAACAACACT
TCTTCAAAAACTAACAAATTTATATGAAAAGTTCGGCTATCATAAAGAACACTTGCACACGATTACGCTAGATGATAGCG
ATGGAACAACTAAAATGAATCAAGTGATAGACGATTTGCGCAAAGAGCCAACTTGTATTCCCGGCATAACGGTTTTAGAA
GACTTTCTAACGAGTAAGCGAACCAATCTTTCAACGATGGAAATGACAAACATAGAGCTACCAAAAGAAAATGTTTTAAA
ATTTTACTTAAACGATAACGCCTGGTTTGCAATACGTCCTTCTGGAACGGAACCGAAATGCAAAATCTATTTCCAAACAA
TCGGTCAAACAGAAGAAATAGCGACAAAAGCTATGGATGAGTTGAAAAAATGCGTTTTAGCCAAATGGGATTAA

Upstream 100 bases:

>100_bases
GTGATACGCTGCATATGTATTACGGCGTGGCGGATACTTCTATGGCGGGCTGTGACATGAAAATCAGCGAAATTCTACAT
CAGTTAGAAGTGGAAAACAA

Downstream 100 bases:

>100_bases
TAAAAAGCTGGAAATTGTTTTCGGACGATTTTCAGCTTTTTTTTAAAGATTTATCTATAAAAATCGCTGAAAAACCCGGA
TAAGCGTACATTTAAAAAGA

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MTWQQHLNAWKNADLSDEWRRELQRVEQEQERFDGYLTFGTGGMRGKMGVGTKRINLFTIRRVAKGLGDYVVANGGAEMG
VAIAYDSRHHSGAFAQETAKVLAAQGVKVYLSDTIRPTPALSFCVREKGAFAGVVITASHNPSIYNGFKVYDKNGCQITL
GVAQEIAGYLENTTDIFTIPVRELPNPLVMTLGKEMDDAYLKALTAVVSRPDLLADYGNKLQICYTPLHGAGKELVMRGL
LENGFSETTMIAEQSEPDGDFPTVVSPNPEEENSFELAKKQAKEIQADIILATDPDADRLGVAVLNKQATYQILTGNQLG
ALLLQYILEAKTSVTQADTMINTIVTGDLGGRIAHDFGINHIQTLTGFKFIGEKIAEMEGTEKNFLFGYEESYGYLIAPF
VRDKDAVQAALLTAEMALFYKKEGTTLLQKLTNLYEKFGYHKEHLHTITLDDSDGTTKMNQVIDDLRKEPTCIPGITVLE
DFLTSKRTNLSTMEMTNIELPKENVLKFYLNDNAWFAIRPSGTEPKCKIYFQTIGQTEEIATKAMDELKKCVLAKWD

Sequences:

>Translated_557_residues
MTWQQHLNAWKNADLSDEWRRELQRVEQEQERFDGYLTFGTGGMRGKMGVGTKRINLFTIRRVAKGLGDYVVANGGAEMG
VAIAYDSRHHSGAFAQETAKVLAAQGVKVYLSDTIRPTPALSFCVREKGAFAGVVITASHNPSIYNGFKVYDKNGCQITL
GVAQEIAGYLENTTDIFTIPVRELPNPLVMTLGKEMDDAYLKALTAVVSRPDLLADYGNKLQICYTPLHGAGKELVMRGL
LENGFSETTMIAEQSEPDGDFPTVVSPNPEEENSFELAKKQAKEIQADIILATDPDADRLGVAVLNKQATYQILTGNQLG
ALLLQYILEAKTSVTQADTMINTIVTGDLGGRIAHDFGINHIQTLTGFKFIGEKIAEMEGTEKNFLFGYEESYGYLIAPF
VRDKDAVQAALLTAEMALFYKKEGTTLLQKLTNLYEKFGYHKEHLHTITLDDSDGTTKMNQVIDDLRKEPTCIPGITVLE
DFLTSKRTNLSTMEMTNIELPKENVLKFYLNDNAWFAIRPSGTEPKCKIYFQTIGQTEEIATKAMDELKKCVLAKWD
>Mature_556_residues
TWQQHLNAWKNADLSDEWRRELQRVEQEQERFDGYLTFGTGGMRGKMGVGTKRINLFTIRRVAKGLGDYVVANGGAEMGV
AIAYDSRHHSGAFAQETAKVLAAQGVKVYLSDTIRPTPALSFCVREKGAFAGVVITASHNPSIYNGFKVYDKNGCQITLG
VAQEIAGYLENTTDIFTIPVRELPNPLVMTLGKEMDDAYLKALTAVVSRPDLLADYGNKLQICYTPLHGAGKELVMRGLL
ENGFSETTMIAEQSEPDGDFPTVVSPNPEEENSFELAKKQAKEIQADIILATDPDADRLGVAVLNKQATYQILTGNQLGA
LLLQYILEAKTSVTQADTMINTIVTGDLGGRIAHDFGINHIQTLTGFKFIGEKIAEMEGTEKNFLFGYEESYGYLIAPFV
RDKDAVQAALLTAEMALFYKKEGTTLLQKLTNLYEKFGYHKEHLHTITLDDSDGTTKMNQVIDDLRKEPTCIPGITVLED
FLTSKRTNLSTMEMTNIELPKENVLKFYLNDNAWFAIRPSGTEPKCKIYFQTIGQTEEIATKAMDELKKCVLAKWD

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=532, Percent_Identity=31.203007518797, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI31377548, Length=559, Percent_Identity=31.484794275492, Blast_Score=238, Evalue=2e-62,
Organism=Escherichia coli, GI1786904, Length=518, Percent_Identity=23.5521235521236, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993870, Length=575, Percent_Identity=31.304347826087, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=312, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323934, Length=554, Percent_Identity=29.7833935018051, Blast_Score=216, Evalue=9e-57,
Organism=Drosophila melanogaster, GI20129809, Length=545, Percent_Identity=30.4587155963303, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24653722, Length=452, Percent_Identity=32.3008849557522, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24651977, Length=435, Percent_Identity=33.1034482758621, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 61902; Mature: 61771

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWQQHLNAWKNADLSDEWRRELQRVEQEQERFDGYLTFGTGGMRGKMGVGTKRINLFTI
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEHHHHH
RRVAKGLGDYVVANGGAEMGVAIAYDSRHHSGAFAQETAKVLAAQGVKVYLSDTIRPTPA
HHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCH
LSFCVREKGAFAGVVITASHNPSIYNGFKVYDKNGCQITLGVAQEIAGYLENTTDIFTIP
HHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHCCCCEEEEEE
VRELPNPLVMTLGKEMDDAYLKALTAVVSRPDLLADYGNKLQICYTPLHGAGKELVMRGL
HHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LENGFSETTMIAEQSEPDGDFPTVVSPNPEEENSFELAKKQAKEIQADIILATDPDADRL
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCHHC
GVAVLNKQATYQILTGNQLGALLLQYILEAKTSVTQADTMINTIVTGDLGGRIAHDFGIN
CCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEHHCCCC
HIQTLTGFKFIGEKIAEMEGTEKNFLFGYEESYGYLIAPFVRDKDAVQAALLTAEMALFY
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
KKEGTTLLQKLTNLYEKFGYHKEHLHTITLDDSDGTTKMNQVIDDLRKEPTCIPGITVLE
CCCCHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHH
DFLTSKRTNLSTMEMTNIELPKENVLKFYLNDNAWFAIRPSGTEPKCKIYFQTIGQTEEI
HHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEECCCHHHH
ATKAMDELKKCVLAKWD
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TWQQHLNAWKNADLSDEWRRELQRVEQEQERFDGYLTFGTGGMRGKMGVGTKRINLFTI
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEHHHHH
RRVAKGLGDYVVANGGAEMGVAIAYDSRHHSGAFAQETAKVLAAQGVKVYLSDTIRPTPA
HHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCH
LSFCVREKGAFAGVVITASHNPSIYNGFKVYDKNGCQITLGVAQEIAGYLENTTDIFTIP
HHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHCCCCEEEEEE
VRELPNPLVMTLGKEMDDAYLKALTAVVSRPDLLADYGNKLQICYTPLHGAGKELVMRGL
HHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LENGFSETTMIAEQSEPDGDFPTVVSPNPEEENSFELAKKQAKEIQADIILATDPDADRL
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCHHC
GVAVLNKQATYQILTGNQLGALLLQYILEAKTSVTQADTMINTIVTGDLGGRIAHDFGIN
CCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEHHCCCC
HIQTLTGFKFIGEKIAEMEGTEKNFLFGYEESYGYLIAPFVRDKDAVQAALLTAEMALFY
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHH
KKEGTTLLQKLTNLYEKFGYHKEHLHTITLDDSDGTTKMNQVIDDLRKEPTCIPGITVLE
CCCCHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHH
DFLTSKRTNLSTMEMTNIELPKENVLKFYLNDNAWFAIRPSGTEPKCKIYFQTIGQTEEI
HHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEECCCHHHH
ATKAMDELKKCVLAKWD
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]