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The map label for this gene is uhpT

Identifier: 226223456

GI number: 226223456

Start: 869527

End: 870912

Strand: Direct

Name: uhpT

Synonym: Lm4b_00854

Alternate gene names: 226223456

Gene position: 869527-870912 (Clockwise)

Preceding gene: 226223455

Following gene: 226223459

Centisome position: 29.85

GC content: 36.72

Gene sequence:

>1386_bases
ATGTCATTATTCAGTTTAAAAAGAAAGAACCATTTTGTTCCACTAGAAATTCAAAGGCAACAATGGTTCAAACACTTTAT
CGTTGCATTTATGTCTGTATTTATTTGTTATCTAACGGTCTATCTTCTAAGGAATAACTTTAAAGCAGCTCAGACATTGT
TAATTGAGCAGAACCATTTCAGCACCACAGAACTAGGAATGATTGGTTTAGCTTTTTCTGTTATGTACGGAATTGGAAAA
ACGATTTTAGGGTATGCCGTGGATGGAAGAAATGCTAAAAAAATAATGAGTTTTTTATTAGGGATTTCCGCTATTATATC
AATTATTATTGGAATACTTTTAGTTACAAAGCAAGCAACAGTGGGTATATTGTTTATCCTTTGGGGAGCAAATGGATTTG
TGCAATCACCAGGTGGACCGGCTTCCTATTCAACTATCACACGATGGACGCCAAAATTGAAAAGAGGAAGATGGTTAGGC
TTTTGGAATGCCTCGCATAATATAGGTGGTGCTTTAGCGGGAATTGTTGCTTTTTGGGGTGCGACTACTTTCTTTAATGG
CGGGGCAGGGGGAATGTTTATCGTTCCGGGTATCATTGCGATCATCATTGCAATTATTTGCTTCTCCGTGGGGCATGATG
AACCAGAAGAATTAGGATGGAACTCTGCCGCTGAAATTTTTGAAGAGCGAGAAGAACAAGGAGAATCGGAGACAAAAGAC
CTTTCTAGATTTCAAATTTTGTGTCGATTTGTTATTAATAATCCTTGGGTATGGACTTTATGTGTCATAAATATATTCAT
CTATATTGTTAGAATTGGTATTGATAATTGGGCGCCCGTTTATTGTATTCAAGCGCTAGGATGGAGCACAAAAGATGCAA
TTATGACTATTTCTTTTTTTGAAATTGGAGCATTGCTAGGTTCATTATCGTGGGGCTGGCTCTCAGATATTATGAAAGGC
CGCCGTATGCTTTGCTCGATTATTGCAGTTGTCATTGAATTTTTCATGTTAATTAGTTATTCGCAAGTTACAAGTGTTTA
TAGCATGTATACGGTATTATTTATTTTAGGATTCTTAGTATTTGGCCCCCAACTTTTAATTGGTGTGTCGGTGATCGAGT
TTGTTCCTAGAAATGCTTTAGCTGTAACAAATGGCTTAACTGGAACGTTTGCATACTTATTCGGAGATTCTTTTGCTAAA
GTCTTTCTAGGATATATCGCAGACCCAACAAAAGCGGGTATACAAATATTTGGCTATACTTTACACGGCTGGGGCGCAAC
TTTTACCATTATGTTTACAGCTTTAATTATTGCAGGCTTAATGATGATTCCAGTTGCATTAAAACAAGAGAAAATCATCC
GACAAGCAAAAGTTTTACATCTATAA

Upstream 100 bases:

>100_bases
CTTTAGAAAAATTGATAGACTTTATATGGAAACGTTTGCGTAATAATGCTCATCGCATTCTAAATTTGGAATGAAAATTA
CACTTGAAAGGAAATTTATA

Downstream 100 bases:

>100_bases
GTTGAAAAGTAATGAGTGAAGATAAACTAATTACTAAAAAGGTATCCTAATTAATAGTATAAGGATACCTTTTTCATTAC
AAAATGGTTTGTTAAATACG

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSLFSLKRKNHFVPLEIQRQQWFKHFIVAFMSVFICYLTVYLLRNNFKAAQTLLIEQNHFSTTELGMIGLAFSVMYGIGK
TILGYAVDGRNAKKIMSFLLGISAIISIIIGILLVTKQATVGILFILWGANGFVQSPGGPASYSTITRWTPKLKRGRWLG
FWNASHNIGGALAGIVAFWGATTFFNGGAGGMFIVPGIIAIIIAIICFSVGHDEPEELGWNSAAEIFEEREEQGESETKD
LSRFQILCRFVINNPWVWTLCVINIFIYIVRIGIDNWAPVYCIQALGWSTKDAIMTISFFEIGALLGSLSWGWLSDIMKG
RRMLCSIIAVVIEFFMLISYSQVTSVYSMYTVLFILGFLVFGPQLLIGVSVIEFVPRNALAVTNGLTGTFAYLFGDSFAK
VFLGYIADPTKAGIQIFGYTLHGWGATFTIMFTALIIAGLMMIPVALKQEKIIRQAKVLHL

Sequences:

>Translated_461_residues
MSLFSLKRKNHFVPLEIQRQQWFKHFIVAFMSVFICYLTVYLLRNNFKAAQTLLIEQNHFSTTELGMIGLAFSVMYGIGK
TILGYAVDGRNAKKIMSFLLGISAIISIIIGILLVTKQATVGILFILWGANGFVQSPGGPASYSTITRWTPKLKRGRWLG
FWNASHNIGGALAGIVAFWGATTFFNGGAGGMFIVPGIIAIIIAIICFSVGHDEPEELGWNSAAEIFEEREEQGESETKD
LSRFQILCRFVINNPWVWTLCVINIFIYIVRIGIDNWAPVYCIQALGWSTKDAIMTISFFEIGALLGSLSWGWLSDIMKG
RRMLCSIIAVVIEFFMLISYSQVTSVYSMYTVLFILGFLVFGPQLLIGVSVIEFVPRNALAVTNGLTGTFAYLFGDSFAK
VFLGYIADPTKAGIQIFGYTLHGWGATFTIMFTALIIAGLMMIPVALKQEKIIRQAKVLHL
>Mature_460_residues
SLFSLKRKNHFVPLEIQRQQWFKHFIVAFMSVFICYLTVYLLRNNFKAAQTLLIEQNHFSTTELGMIGLAFSVMYGIGKT
ILGYAVDGRNAKKIMSFLLGISAIISIIIGILLVTKQATVGILFILWGANGFVQSPGGPASYSTITRWTPKLKRGRWLGF
WNASHNIGGALAGIVAFWGATTFFNGGAGGMFIVPGIIAIIIAIICFSVGHDEPEELGWNSAAEIFEEREEQGESETKDL
SRFQILCRFVINNPWVWTLCVINIFIYIVRIGIDNWAPVYCIQALGWSTKDAIMTISFFEIGALLGSLSWGWLSDIMKGR
RMLCSIIAVVIEFFMLISYSQVTSVYSMYTVLFILGFLVFGPQLLIGVSVIEFVPRNALAVTNGLTGTFAYLFGDSFAKV
FLGYIADPTKAGIQIFGYTLHGWGATFTIMFTALIIAGLMMIPVALKQEKIIRQAKVLHL

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=389, Percent_Identity=23.1362467866324, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4503847, Length=389, Percent_Identity=23.1362467866324, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI256219483, Length=389, Percent_Identity=23.1362467866324, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI256219543, Length=403, Percent_Identity=21.5880893300248, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38093649, Length=415, Percent_Identity=24.578313253012, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI223717983, Length=415, Percent_Identity=24.578313253012, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI46361976, Length=412, Percent_Identity=23.5436893203883, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI256219564, Length=291, Percent_Identity=23.0240549828179, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI2367259, Length=460, Percent_Identity=45.6521739130435, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI87082310, Length=439, Percent_Identity=29.3849658314351, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788573, Length=442, Percent_Identity=26.9230769230769, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17542316, Length=476, Percent_Identity=22.8991596638655, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133930953, Length=464, Percent_Identity=22.6293103448276, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI133901854, Length=470, Percent_Identity=22.1276595744681, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI133901856, Length=470, Percent_Identity=22.1276595744681, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656866, Length=438, Percent_Identity=22.8310502283105, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550478, Length=438, Percent_Identity=22.8310502283105, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656861, Length=436, Percent_Identity=22.7064220183486, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51222; Mature: 51091

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSLKRKNHFVPLEIQRQQWFKHFIVAFMSVFICYLTVYLLRNNFKAAQTLLIEQNHF
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCC
STTELGMIGLAFSVMYGIGKTILGYAVDGRNAKKIMSFLLGISAIISIIIGILLVTKQAT
CHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VGILFILWGANGFVQSPGGPASYSTITRWTPKLKRGRWLGFWNASHNIGGALAGIVAFWG
HEEEEEEECCCCEEECCCCCCCCCHHHHCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHH
ATTFFNGGAGGMFIVPGIIAIIIAIICFSVGHDEPEELGWNSAAEIFEEREEQGESETKD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHH
LSRFQILCRFVINNPWVWTLCVINIFIYIVRIGIDNWAPVYCIQALGWSTKDAIMTISFF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHEEHHHH
EIGALLGSLSWGWLSDIMKGRRMLCSIIAVVIEFFMLISYSQVTSVYSMYTVLFILGFLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGPQLLIGVSVIEFVPRNALAVTNGLTGTFAYLFGDSFAKVFLGYIADPTKAGIQIFGYT
HHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LHGWGATFTIMFTALIIAGLMMIPVALKQEKIIRQAKVLHL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLFSLKRKNHFVPLEIQRQQWFKHFIVAFMSVFICYLTVYLLRNNFKAAQTLLIEQNHF
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCC
STTELGMIGLAFSVMYGIGKTILGYAVDGRNAKKIMSFLLGISAIISIIIGILLVTKQAT
CHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VGILFILWGANGFVQSPGGPASYSTITRWTPKLKRGRWLGFWNASHNIGGALAGIVAFWG
HEEEEEEECCCCEEECCCCCCCCCHHHHCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHH
ATTFFNGGAGGMFIVPGIIAIIIAIICFSVGHDEPEELGWNSAAEIFEEREEQGESETKD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHH
LSRFQILCRFVINNPWVWTLCVINIFIYIVRIGIDNWAPVYCIQALGWSTKDAIMTISFF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHEEHHHH
EIGALLGSLSWGWLSDIMKGRRMLCSIIAVVIEFFMLISYSQVTSVYSMYTVLFILGFLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGPQLLIGVSVIEFVPRNALAVTNGLTGTFAYLFGDSFAKVFLGYIADPTKAGIQIFGYT
HHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LHGWGATFTIMFTALIIAGLMMIPVALKQEKIIRQAKVLHL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]