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The map label for this gene is glmS [H]

Identifier: 226223357

GI number: 226223357

Start: 765217

End: 767022

Strand: Direct

Name: glmS [H]

Synonym: Lm4b_00754

Alternate gene names: 226223357

Gene position: 765217-767022 (Clockwise)

Preceding gene: 226223355

Following gene: 226223358

Centisome position: 26.27

GC content: 39.81

Gene sequence:

>1806_bases
ATGTGTGGAATCGTTGGATATATTGGAACAAATAATGCAAAAGGCATTTTATTAGAAGGACTTGAAAAATTAGAATACCG
CGGCTATGACTCTGCGGGAATCGCTTTGCAAAACAAAGACCTAGTAACAGTAGTTAAAGAAAAAGGACGGATTGCAGACC
TTGCGAGCCTTGTACCAAGTGATGCATTCGGTACAACAGGAATCGGACATACACGCTGGGCAACGCACGGTAAACCAAAT
CACGAAAACGCCCACCCGCACCAAAGCAAATCTGGTCGTTTTACAATGGTTCATAACGGCGTAATCGAAAACTATACCCT
TTTAAAAGAAGAATACTTAAAAAATCATTCATTTGTTAGTGATACGGATACAGAAGTAATCGTTCAGCTTATTGAACTCT
TTGCAGCAGAACTTTCGACTAAAGAAGCATTCAAAAAAGCGTTATCGTTACTTCATGGTTCTTACGCGATCTGCTTAATT
GACCAAACCGATACAGAAACACTATACGCAGCAAAAAACAAAAGCCCATTACTAATCGGAAAAGGCGAAAACTTCAACGT
TATTGCAAGTGATGCAATGGCTGTTCTTAAAGAAACAGATGAATTCGTGGAAATTATGGATAAAGAAATCGTTATCGTTA
CAAAAGACGGTTTTACATTAGAAACATTAGAAGGGGAAGAAATTAGCCGCGCGAGCTACACTGCTGAATTAGATGCATCT
GACATCGAAAAAGGCACATACCCGCACTATATGTTAAAAGAAATCGACGAACAACCAGCAGTAACACGTAAAATCATCCA
AGCTTACCAAAACGAAGCTGGGGAAATCAATGTCGATCAAACAATCCTTGATGAAATTTTATCTTCTGACCGTATTCATA
TTGTCGCTTGTGGTACGAGCTATCATGCTGGTTTAGTCGGAAAAAATTTAATCGAAAAAATGGCGAAAATTCCTGTAGAA
GTACATGTTTCTAGTGAATTTGGTTATAATTTACCGCTAATGTCTAAAAAGCCGTTATTCATTTTCATTACCCAAAGTGG
GGAAACAGCTGATAGCCGCCAATGCCTTGTAAAAGTGAAAGAACTTGGTTACCGGACGCTGACATTAACGAACGTACCAG
GCTCTACGCTTGACCGTGAAGCGGATCATTCGATGTATCTCTATGCTGGACCTGAAATTGCGGTTGCATCAACAAAAGCA
TATACCGCACAGATTTCGGTTTTAGCAGTACTTGCAGTTTCACTTGGTCGCGAAATTGGTGATGCTGAAGCGCTTAGCAT
TAATTTAGCTGCTGAATTAGGTATCGTTGCAACTGCAATGGAAGCAATGGTTTCTAGTAAAGAAGTTATCGAACATATTG
CGGGCGAATACTTAGCGACTTCTCGTAACGCCTTCTTCTTAGGTAGAAACATCGATTATTTCGTAGCGATGGAAGCAGCA
CTTAAACTAAAAGAAATTTCATATATTCAAGCAGAAGGTTTTGCAAGTGGGGAATTAAAACATGGTACTATTGCGCTTAT
TGAAGATGGCACACCAGTTTTAGCACTTATCACGCAAGAATCTATCAACTGGAATATTCGCGGAAATGTAAATGAAGTCT
TAGCGCGTGGAGCAAAAACTTGTGTATTTGCAATGGAAAACGTTGCGCAACCAGGTGACCGCTTTGTTATTCCGCAAGTG
CATCCATTATTAACACCACTAGCGAGCGTTATCCCGTGTCAATTATTAGCTTATTACGCAGCACTTCACCGTGACTGTGA
TGTCGATAAACCAAGAAACTTAGCAAAAAGTGTCACAGTAGAATAA

Upstream 100 bases:

>100_bases
TAATGAAACATGTTTTTTACCCTCCAAGGAAACCAAAAAATGTAGAGGGCTTGAAATTGGATAAGTCTGCCCTCAAGTTA
ATTATTGGAGGAGTTTTACT

Downstream 100 bases:

>100_bases
AGTATTCAAGACCTTTTCGAGATTAGAAAAGGTCTTTTTTTATGTAATCAATAAATTTGCACGACGCCCTTGTTATACTA
TAAACTTAGAGAGGAATGGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKDLVTVVKEKGRIADLASLVPSDAFGTTGIGHTRWATHGKPN
HENAHPHQSKSGRFTMVHNGVIENYTLLKEEYLKNHSFVSDTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLI
DQTDTETLYAAKNKSPLLIGKGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEISRASYTAELDAS
DIEKGTYPHYMLKEIDEQPAVTRKIIQAYQNEAGEINVDQTILDEILSSDRIHIVACGTSYHAGLVGKNLIEKMAKIPVE
VHVSSEFGYNLPLMSKKPLFIFITQSGETADSRQCLVKVKELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKA
YTAQISVLAVLAVSLGREIGDAEALSINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAA
LKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKTCVFAMENVAQPGDRFVIPQV
HPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTVE

Sequences:

>Translated_601_residues
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKDLVTVVKEKGRIADLASLVPSDAFGTTGIGHTRWATHGKPN
HENAHPHQSKSGRFTMVHNGVIENYTLLKEEYLKNHSFVSDTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLI
DQTDTETLYAAKNKSPLLIGKGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEISRASYTAELDAS
DIEKGTYPHYMLKEIDEQPAVTRKIIQAYQNEAGEINVDQTILDEILSSDRIHIVACGTSYHAGLVGKNLIEKMAKIPVE
VHVSSEFGYNLPLMSKKPLFIFITQSGETADSRQCLVKVKELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKA
YTAQISVLAVLAVSLGREIGDAEALSINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAA
LKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKTCVFAMENVAQPGDRFVIPQV
HPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTVE
>Mature_601_residues
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKDLVTVVKEKGRIADLASLVPSDAFGTTGIGHTRWATHGKPN
HENAHPHQSKSGRFTMVHNGVIENYTLLKEEYLKNHSFVSDTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLI
DQTDTETLYAAKNKSPLLIGKGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEISRASYTAELDAS
DIEKGTYPHYMLKEIDEQPAVTRKIIQAYQNEAGEINVDQTILDEILSSDRIHIVACGTSYHAGLVGKNLIEKMAKIPVE
VHVSSEFGYNLPLMSKKPLFIFITQSGETADSRQCLVKVKELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKA
YTAQISVLAVLAVSLGREIGDAEALSINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAA
LKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKTCVFAMENVAQPGDRFVIPQV
HPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=31.7391304347826, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=30.9248554913295, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=41.4355628058728, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI87082251, Length=336, Percent_Identity=22.0238095238095, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=717, Percent_Identity=29.9860529986053, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=31.0904872389791, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=31.0904872389791, Blast_Score=205, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=33.0254041570439, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=382, Percent_Identity=26.9633507853403, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=38.2352941176471, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=31.1239193083574, Blast_Score=311, Evalue=6e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65618; Mature: 65618

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKDLVTVVKEKGRIADLASLVPS
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCHHHHHHHCCC
DAFGTTGIGHTRWATHGKPNHENAHPHQSKSGRFTMVHNGVIENYTLLKEEYLKNHSFVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
DTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLIDQTDTETLYAAKNKSPLLIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEE
KGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEISRASYTAELDAS
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHEEEECCHH
DIEKGTYPHYMLKEIDEQPAVTRKIIQAYQNEAGEINVDQTILDEILSSDRIHIVACGTS
HCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
YHAGLVGKNLIEKMAKIPVEVHVSSEFGYNLPLMSKKPLFIFITQSGETADSRQCLVKVK
CCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
ELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKAYTAQISVLAVLAVSLGREIG
HCCCEEEEEECCCCCCCCCCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
DAEALSINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHH
LKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKT
HHHHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEECCCHHHHHHCCCHH
CVFAMENVAQPGDRFVIPQVHPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTV
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
E
C
>Mature Secondary Structure
MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKDLVTVVKEKGRIADLASLVPS
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCHHHHHHHCCC
DAFGTTGIGHTRWATHGKPNHENAHPHQSKSGRFTMVHNGVIENYTLLKEEYLKNHSFVS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
DTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLIDQTDTETLYAAKNKSPLLIG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEE
KGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEISRASYTAELDAS
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHEEEECCHH
DIEKGTYPHYMLKEIDEQPAVTRKIIQAYQNEAGEINVDQTILDEILSSDRIHIVACGTS
HCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
YHAGLVGKNLIEKMAKIPVEVHVSSEFGYNLPLMSKKPLFIFITQSGETADSRQCLVKVK
CCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
ELGYRTLTLTNVPGSTLDREADHSMYLYAGPEIAVASTKAYTAQISVLAVLAVSLGREIG
HCCCEEEEEECCCCCCCCCCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
DAEALSINLAAELGIVATAMEAMVSSKEVIEHIAGEYLATSRNAFFLGRNIDYFVAMEAA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHH
LKLKEISYIQAEGFASGELKHGTIALIEDGTPVLALITQESINWNIRGNVNEVLARGAKT
HHHHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEECCCHHHHHHCCCHH
CVFAMENVAQPGDRFVIPQVHPLLTPLASVIPCQLLAYYAALHRDCDVDKPRNLAKSVTV
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]