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The map label for this gene is tlpA [H]

Identifier: 226223354

GI number: 226223354

Start: 761968

End: 763773

Strand: Direct

Name: tlpA [H]

Synonym: Lm4b_00751

Alternate gene names: 226223354

Gene position: 761968-763773 (Clockwise)

Preceding gene: 226223353

Following gene: 226223355

Centisome position: 26.16

GC content: 38.43

Gene sequence:

>1806_bases
GTGAATTTAATTAAAAATCGTAAATTGAAAACAAAATTAAGCATCAATATTGTTATAACGACCATCATGTTAATCGGACT
TGGCGCGACTAGCTTTCTTGGCTTTCGTCATGTAGCAACACTTTCAGATAATATGGTTGATAATAATGTCGCACCGATGA
AAGAAATCGCAAAAATCCAAACAAACATGGCGCAAATCAATATCGACATCCTGACCATGTTCGACACTATTAACGGAAAA
TCAGCTCTTATAAAAGATATTGATGATCTTTATGCCGAAAATGACCAAGCAATTCATAATTTCAAAAAAGCCAATTTAAC
AGCAGAAGATAAAAAACAATTAGCGTACTTTGAAGAAAAACTAGCGGACATGAAATCATCCGCATCCTCAGTAATCAGTG
ACACATCAAGCGCACTAGACGACGCAGAACTACTTGGAGCGCAAAACAGATACTACCAAAACGTCAAAACAAAATTTGAC
GATGCAACTAAACAATTAAACGTTTTAAATGAAATGAACTACAAAGAAGTCGAAAATTCTTCTCAAGCAATTTCTGACTT
TGGTGTAAAAATCAGTATCATTTTCACAGCAGTTATTATTGCCGTGCTAATTTCTCTATTCATTTTTAATGCTTATATTA
CAAGAGTGATTCTAAAAGGAATCCGTCACTTGCAAACAGCTGTACATAAAGTAGCTAGTGGAGATTTGTCGTACCGCAGC
ACTTATAACGGTAGAGACGAGCTTGGTGATATTACAAACGACTTGAATGAAATGAGCGAAAACCTAAGATTAATGATTGA
AGACGTTAAAAAAGCTTCTACAGACGTTAAATCTTCCAGTGATAACGTTATTATTAGTTCGGAAATTATTTCTGCAATGA
CGACAGAAATGGACATCGAAATGAAAATGATGGGTGAGCAAATCCAAACACAAATCGGCAGCATGAAAGAAAGCACGGAT
GCAATGGATCAAATGACTGGCGGCGTTCAAAATGTGGCTGAATACGCGCTTAAAGTATCTGACCTAACAAAAGATTCCGC
AGAAAAAACGAACGATGGCATTGCCGTTATCAATAATCTCGTGTCCCAAATGGACCGTATCAGTGGCGTTATGCGTTCAA
GTACAGACGTTGTTTCTCAATTAGTTAACCGCGTTGGTGAAGTGGAAAAAGCGCTGGATACCGTTACAAATATCGCTGAC
CAAACCAACTTGCTTGCCCTAAATGCGGCAATCGAATCTGCTCGTGCTGGTGAACATGGCCGTGGATTTGCAGTCGTAGC
CGAAGAAGTCCGCAAACTAGCTGAACAATCACGACTTGCTGTTGTTGACATTAATACTGTTCTGAAAAAAATTCAAACAG
AATCAAAAACTACTATCGAAGTAATGAACACAGGTCTTTCCGAATCAGAAGCTGGCCAAAAAATCATTTCTGAAACGGAA
GCAACTTTCACAGACTTACTCAATCGTGTCAATGATATTTCCGCTCAAATGCAAAATGTATCTCAAGAAACCGAAGAAAT
GGCTGCGGGAATTGAAGAAGTCAACACGTCAATTAGCGACGTAACAGAAATTTCCAATCAAATCGGTGAAAAATCCACTG
CTGCACTTGAATTCGCAGAAGTAAACAAAATGAAAGTGGACGAGCTAGTTGTTATCTCCGAAGAAATGCAAAAAATTTCT
GGTTCATTAGAAGGGTATATCGCCAACTTCAATACCGAAGTGAGCGAAGAAGCGGTCGAAGTAACAGAAGAGCCAGAATC
AGAAACAAAAGATCCAGGAGAGCCAGTCCTAGCAGAAAATGTCTAG

Upstream 100 bases:

>100_bases
CGTTTTTTTATTAAAACTAATTATTTTACAATAAAATATGGAGTTTTTTTAAAAAATATGAGATAATAAATTAGAATTAG
AGAATAGGAGTGTGGAATGG

Downstream 100 bases:

>100_bases
GAAGCATGTATAATGCGAATTTGGATAAAATCACTGCTTGTCATTACAGCGTGTATATTTAGTTTGACCCTTCTAAATAC
GAAATATACCTTTTATTCAC

Product: metyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVATLSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
SALIKDIDDLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYKEVENSSQAISDFGVKISIIFTAVIIAVLISLFIFNAYITRVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEAVEVTEEPESETKDPGEPVLAENV

Sequences:

>Translated_601_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVATLSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
SALIKDIDDLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYKEVENSSQAISDFGVKISIIFTAVIIAVLISLFIFNAYITRVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEAVEVTEEPESETKDPGEPVLAENV
>Mature_601_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVATLSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
SALIKDIDDLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYKEVENSSQAISDFGVKISIIFTAVIIAVLISLFIFNAYITRVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEAVEVTEEPESETKDPGEPVLAENV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=348, Percent_Identity=27.2988505747126, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788194, Length=611, Percent_Identity=24.5499181669394, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI2367378, Length=334, Percent_Identity=29.6407185628743, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788195, Length=315, Percent_Identity=26.3492063492064, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789453, Length=343, Percent_Identity=25.3644314868805, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 65880; Mature: 65880

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVATLSDNMVDNNVAPMKEIAKIQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TNMAQINIDILTMFDTINGKSALIKDIDDLYAENDQAIHNFKKANLTAEDKKQLAYFEEK
HHHHHEEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
LADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFDDATKQLNVLNEMNYKEVENS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SQAISDFGVKISIIFTAVIIAVLISLFIFNAYITRVILKGIRHLQTAVHKVASGDLSYRS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKMMGEQIQTQIGSMKESTDAMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHH
VSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIADQTNLLALNAAIESARAGEHG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
RGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHH
VNKMKVDELVVISEEMQKISGSLEGYIANFNTEVSEEAVEVTEEPESETKDPGEPVLAEN
HCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
V
C
>Mature Secondary Structure
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVATLSDNMVDNNVAPMKEIAKIQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TNMAQINIDILTMFDTINGKSALIKDIDDLYAENDQAIHNFKKANLTAEDKKQLAYFEEK
HHHHHEEEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
LADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFDDATKQLNVLNEMNYKEVENS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SQAISDFGVKISIIFTAVIIAVLISLFIFNAYITRVILKGIRHLQTAVHKVASGDLSYRS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKMMGEQIQTQIGSMKESTDAMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHH
VSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIADQTNLLALNAAIESARAGEHG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
RGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHH
VNKMKVDELVVISEEMQKISGSLEGYIANFNTEVSEEAVEVTEEPESETKDPGEPVLAEN
HCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]