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The map label for this gene is atpA1 [H]

Identifier: 226222728

GI number: 226222728

Start: 99524

End: 101020

Strand: Direct

Name: atpA1 [H]

Synonym: Lm4b_00093

Alternate gene names: 226222728

Gene position: 99524-101020 (Clockwise)

Preceding gene: 226222727

Following gene: 226222729

Centisome position: 3.42

GC content: 39.35

Gene sequence:

>1497_bases
TTGAAAACAATTCATTTTGATATGAACAAATACGAAACCCATGTGGACTTGGAATATTTGAAAGAACATGGCCGAGTGGA
AAAAATTTCTGATGGAGTTATTTTCTGCTCAGGCCTAGAAAATGCAGCGCTACATCAGGCTGTTTTAATTGATGAAAGGC
ACCGAGGTGTAATTCTGGAGCTCAATGAGGAATTTGTCGGAATCGGTTTGATTGATAAGACGAATGACATTTTAGAAGGT
ATGCATGTTGGGGTCTCCGGCAAATTTATCGAAGTAGACCTATTTGAAGAAATGGCAGGGCGTGTTATTGATACTACAGG
AAAAATGCTTTATGAAGAAAGTGAAGAAAAGCCGACAGCAACCTCTCCACTTTTCTGTGTAACTCCAGCTATTATGACGA
TTGATAGTGTAACACGCCCGCTTAATACGGGGCTTGCGGTGATTGATTCTATTACGCCAATTGGTCGAGGTCAGCGTCAA
TTAATCCTTGGCAATCGCCAGTCTGGGAAAACACAAATTGCTGTGGATACGATAATTAACCAACATGATCAAAATGTGCA
TTGCATCTATGTTGCTATTGGCTTAAAAGCAGCTTATATCGCAGAAGTTATTGAAACTCTTCGAAATCATGGAGCAATGG
AATATTCTACGGTTGTTGCAACTGCAGCCAGTGATTCCCTTACCGCGCAATATTTAACACCGTATGCGGGTATGGCAGTA
GCGGAAGCCTTGCGAGATCAAGGTAAAGATGTACTCATCATTTTAGATGATTTAACCAAACATGCGGATGCTTATCGAGC
AATTACTTTACTCTTTAACCGCCCGCCAGGAAGAGAAGCTTATCCAGGAGATAGTTTTTATATTCACTCTAGCCTCTTAG
AAAGGGCCGTTCAAATGAATGAAGAACATGGTGGCGGTTCTATTACAGCAATACCGATGATTGAAACTCTATCAGATGAT
GTAACAGCTTATATCCCTACTAATGTTATCTCTATTACAGATGGGCAATTATTTTTAAAATCGGATTTATTCAACCGTGG
TCAAAAGCCAGCCGTAGATGTTGGTGTGTCTGTTTCAAGGATTGGCGGCGATGCACAACACCCAATTATCCGCAAATTAA
GTAAAAACTTAACGTTGATTCTTTCGCAGTTTGAGGAATTAAAAGAATTACTCGATTTTGGTAATGCACTTGATGATGGC
AGTATGAAAATGGTATCGGATGGCCGATTATTAACAGAATTATTCAAGCAAAAAATTCTAAGCCCGTTATCAGTAACGGA
ATTAATCGTTATTTTATATGCTTTCCAAAATGGCTTTCTAACAAAAATCCCGCCTGCCAATATTCAGACTTTCAAAGACC
TTTTGCTAGAAAAAGCGCATATGCATAAAGATTTTGAGTCGTTTTCAGCTCAGATAGAAACGATTAATGAACTGAATGAA
TCGCACATCGAAATGCTAGAAGAGATCATTCGGGAAGCTGGGAGGCTTTTTAGTTGA

Upstream 100 bases:

>100_bases
TTGGCGGAGTGATTATTCAATATGGTTCTAAATCAATTGATATGAGCTACCAGGAATTAATTAAACGATCAACAGAAAAA
ATGGAAGCGGAAGTGAAACT

Downstream 100 bases:

>100_bases
GTAGCATAGACCAAGCCCGAAAAACCATTAAAGCACTAAATTCAACCTATAAAATAGTCCATGTAACAGAACTAGCGACA
CTCGGAAAACTTTCCGCCTT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 1; F-ATPase subunit alpha 1 [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTNDILEG
MHVGVSGKFIEVDLFEEMAGRVIDTTGKMLYEESEEKPTATSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMAV
AEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNEEHGGGSITAIPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDG
SMKMVSDGRLLTELFKQKILSPLSVTELIVILYAFQNGFLTKIPPANIQTFKDLLLEKAHMHKDFESFSAQIETINELNE
SHIEMLEEIIREAGRLFS

Sequences:

>Translated_498_residues
MKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTNDILEG
MHVGVSGKFIEVDLFEEMAGRVIDTTGKMLYEESEEKPTATSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMAV
AEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNEEHGGGSITAIPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDG
SMKMVSDGRLLTELFKQKILSPLSVTELIVILYAFQNGFLTKIPPANIQTFKDLLLEKAHMHKDFESFSAQIETINELNE
SHIEMLEEIIREAGRLFS
>Mature_498_residues
MKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTNDILEG
MHVGVSGKFIEVDLFEEMAGRVIDTTGKMLYEESEEKPTATSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMAV
AEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNEEHGGGSITAIPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDG
SMKMVSDGRLLTELFKQKILSPLSVTELIVILYAFQNGFLTKIPPANIQTFKDLLLEKAHMHKDFESFSAQIETINELNE
SHIEMLEEIIREAGRLFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=487, Percent_Identity=42.5051334702259, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI4757810, Length=487, Percent_Identity=42.5051334702259, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI19913426, Length=302, Percent_Identity=27.1523178807947, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI19913428, Length=336, Percent_Identity=25.297619047619, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI32189394, Length=388, Percent_Identity=23.4536082474227, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790172, Length=469, Percent_Identity=42.4307036247335, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788251, Length=411, Percent_Identity=25.7907542579075, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790170, Length=308, Percent_Identity=21.7532467532468, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988063, Length=474, Percent_Identity=42.8270042194093, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71988080, Length=474, Percent_Identity=42.8270042194093, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71988074, Length=474, Percent_Identity=41.3502109704641, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI17570191, Length=330, Percent_Identity=26.969696969697, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17510931, Length=316, Percent_Identity=25.9493670886076, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI25144756, Length=334, Percent_Identity=22.4550898203593, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=485, Percent_Identity=41.0309278350515, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319603, Length=333, Percent_Identity=26.7267267267267, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=310, Percent_Identity=23.2258064516129, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320016, Length=217, Percent_Identity=26.2672811059908, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24658560, Length=479, Percent_Identity=40.9185803757829, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281361666, Length=314, Percent_Identity=27.3885350318471, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24646341, Length=314, Percent_Identity=27.3885350318471, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136796, Length=314, Percent_Identity=27.3885350318471, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24638766, Length=362, Percent_Identity=23.4806629834254, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55143; Mature: 55143

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILE
CCEEEECCCCCCHHCCHHHHHHCCCEEEECCCEEEECCCCCHHHHHHHEEECCCCCEEEE
LNEEFVGIGLIDKTNDILEGMHVGVSGKFIEVDLFEEMAGRVIDTTGKMLYEESEEKPTA
ECCCEEEEEEECCCHHHHHHHCCCCCCCEEEEEHHHHHCCCEECCCHHHHHHCCCCCCCC
TSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQLILGNRQSGKTQIAVDTIIN
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHC
QHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMAV
CCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEHHEEEECCCCCCHHHHHCCHHHHHH
AEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMN
HHHHHHCCCEEEEEECCHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHCC
EEHGGGSITAIPMIETLSDDVTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSR
CCCCCCCEEEEEEHHHHCCCCEEEECCCEEEECCCCEEEEHHHHCCCCCCCEECCCCHHH
IGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDGSMKMVSDGRLLTELFKQKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCC
SPLSVTELIVILYAFQNGFLTKIPPANIQTFKDLLLEKAHMHKDFESFSAQIETINELNE
CCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SHIEMLEEIIREAGRLFS
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTIHFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILE
CCEEEECCCCCCHHCCHHHHHHCCCEEEECCCEEEECCCCCHHHHHHHEEECCCCCEEEE
LNEEFVGIGLIDKTNDILEGMHVGVSGKFIEVDLFEEMAGRVIDTTGKMLYEESEEKPTA
ECCCEEEEEEECCCHHHHHHHCCCCCCCEEEEEHHHHHCCCEECCCHHHHHHCCCCCCCC
TSPLFCVTPAIMTIDSVTRPLNTGLAVIDSITPIGRGQRQLILGNRQSGKTQIAVDTIIN
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHC
QHDQNVHCIYVAIGLKAAYIAEVIETLRNHGAMEYSTVVATAASDSLTAQYLTPYAGMAV
CCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEHHEEEECCCCCCHHHHHCCHHHHHH
AEALRDQGKDVLIILDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMN
HHHHHHCCCEEEEEECCHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHCC
EEHGGGSITAIPMIETLSDDVTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSR
CCCCCCCEEEEEEHHHHCCCCEEEECCCEEEECCCCEEEEHHHHCCCCCCCEECCCCHHH
IGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNALDDGSMKMVSDGRLLTELFKQKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCC
SPLSVTELIVILYAFQNGFLTKIPPANIQTFKDLLLEKAHMHKDFESFSAQIETINELNE
CCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SHIEMLEEIIREAGRLFS
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]