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The map label for this gene is norM [H]

Identifier: 225861884

GI number: 225861884

Start: 1918007

End: 1919287

Strand: Reverse

Name: norM [H]

Synonym: SPT_2060

Alternate gene names: 225861884

Gene position: 1919287-1918007 (Counterclockwise)

Preceding gene: 225861885

Following gene: 225861883

Centisome position: 90.87

GC content: 44.03

Gene sequence:

>1281_bases
TTGTTTAAGAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTTTTGCAGATGCTAATGGGAAT
GGTGGACAGTTATTTGGTTGCTCATTTAGGATTGATAGCTATTTCAGGGGTTTCAGTAGCTGGTAATATTATCACCATTT
ATCAGGCGATTTTCATCGCTCTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAAGACCAGTCGAAG
TTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTTACTATTAAGTTTCCTTTTAGGATTTTTGTCCATCTTCGCTGG
GAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTAGCTGAGAGTGGTGGACTGTATCTATCTTTGGTAGGCGGAT
CGATTGTTCTCTTAGGTTTAATGACTAGTCTGGGAGCCTTGATTCGTGCAACGCATAATCCACGTTTGCCTCTCTATGTT
AGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGTTCTGGATATGGGGATAGCTGGTGTTGC
TTGGGGGACAATTCTGTCTCGTTTGGTTGGTCTTGTGATTTTGTGGTCACAATTAAAACTGCCTTATGGGAAGCCAACTT
TTGGTTTAGATAAGGAACTGTTGACCTTGGCTTTACCAGCAGCTGGAGAGCGACTTATGATGAGGGCTGGAGATGTAGTG
ATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCTGGGAATGCAATCGGAGAAGTCTTGACCCAGTTTAACTA
TATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATGCTGTTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTCG
CTAGTTTGAGTAAACAAACCTTTTGGCTTTCTCTGTTCCTCATGTTGCCCCTGTCCTTTAGTATATATGTCTTGGGTGTA
CCATTAACTCATCTCTATACGACTGATTCTCTAGCGGTGGAGGCTAGTGTTCTAGTGACACTGTTTTCACTACTTGGAAC
CCCTATGACGACAGGAACAGTCATCTATACGGCAGTCTGGCAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAA
GTATAGGCATGTGGTGTATCCGCATTGGAACAGGATATCTGCTGGGGATTGTGCTTGGTTGGGGCTTGCCTGGTATTTGG
GCAGGGTCTCTCTTGGATAATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGCTATATGAGCTTGAAAGGATA
G

Upstream 100 bases:

>100_bases
TGACATGCAAGCAGCGGTTGAGGCTTATTTAGGACTTTAAGACAGAGGGAGCAAACTCGGTTGGGAAACCAACTGAGTTT
CTTTTCATCAGGAGGAGAGA

Downstream 100 bases:

>100_bases
GAAATGCAAAAAACAGCTTTTATTTGGGATTTAGACGGGACTTTATTGGACTCTTACGAAGCGATTTTATCAGGGATTGA
GGAGACTTTTGCTCAGTTTT

Product: multi antimicrobial extrusion

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSK
LAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
SFLSNALNILFSSLAIFVLDMGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVV
IIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGV
PLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLLGIVLGWGLPGIW
AGSLLDNGFRWLFLRYRYQRYMSLKG

Sequences:

>Translated_426_residues
MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSK
LAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
SFLSNALNILFSSLAIFVLDMGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVV
IIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGV
PLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLLGIVLGWGLPGIW
AGSLLDNGFRWLFLRYRYQRYMSLKG
>Mature_426_residues
MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSK
LAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
SFLSNALNILFSSLAIFVLDMGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVV
IIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGV
PLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLLGIVLGWGLPGIW
AGSLLDNGFRWLFLRYRYQRYMSLKG

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=435, Percent_Identity=26.4367816091954, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 45898; Mature: 45898

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIA
CCCCCCCCEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHH
AESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFLSNALNILFSSLAIFVLD
HHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCHH
IIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQT
HHHHHHHHCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVW
HHHHHHHHHHHHHEEEEEECCHHHHEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QGLGNARLPFYATSIGMWCIRIGTGYLLGIVLGWGLPGIWAGSLLDNGFRWLFLRYRYQR
HCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
YMSLKG
HHCCCC
>Mature Secondary Structure
MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIA
CCCCCCCCEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHH
AESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFLSNALNILFSSLAIFVLD
HHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCHH
IIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQT
HHHHHHHHCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVW
HHHHHHHHHHHHHEEEEEECCHHHHEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QGLGNARLPFYATSIGMWCIRIGTGYLLGIVLGWGLPGIWAGSLLDNGFRWLFLRYRYQR
HCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHH
YMSLKG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]