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The map label for this gene is pcp2 [H]

Identifier: 225861879

GI number: 225861879

Start: 1914196

End: 1914840

Strand: Reverse

Name: pcp2 [H]

Synonym: SPT_2055

Alternate gene names: 225861879

Gene position: 1914840-1914196 (Counterclockwise)

Preceding gene: 225861880

Following gene: 225861877

Centisome position: 90.66

GC content: 44.5

Gene sequence:

>645_bases
ATGAAAGTATTAGTGACAGGTTTTGAGCCCTTTGGAGGGGAAAAGGGCAATCCAACTTTGGAGGCCATTAAAGGTTTACC
AGCTGAAATCCATGGTGCTGAGGTCCGTTGGCTAGAGGTGCCGACAGTTTTTCACAAATCTGCTCAAGTATTGGAAGAAG
AGATGAATCGTTATCAACCTGACTTTGTCCTTTGTATTGGGCAAGCTGGTGGAAGAACTAGTGTGACACCTGAACGAGTG
GCCATTAATCAAGACGATGCACGCATTTCTGATAACGAAGATAATCAACCGATTGACCGTCCCATTCGCCCAGATGGTGC
TTCGGCCTACTTTAGTAGTTTGCCGATTAAAGCGATGGTTCAAGCTATAAAAAAAGAGGGCTTACCGGCCTCTGTTTCCA
ATACGGCAGGGACTTTTGTCTGCAGCCATTTGATGTATCAGGCTCTCTATTTGGTAGAAAAGAAATTTCCATATGTTAAG
GCAGGTTTTATGCATATTCCTTATATGATGGAACAGGTGGTGAACAGACCGACTACTCCAACTATGAGTTTAGTGGATAT
TCGGCGAGGGATAGAAGCAGCAATCGGCGCTATGATAGAACATGGAGATCAGGAACTCAAGTTGGTAGGCGGAGAAACTC
ATTGA

Upstream 100 bases:

>100_bases
ATTCTAATCTCGCTAATCCTTTTTAATCCAGAATAAGGGAAATATGTTATACTTGTTTTTAAGAAAAAAGTCTCATTGAA
TTGGTTTTGAGGAGTTAGAA

Downstream 100 bases:

>100_bases
TAGAAAAAAGCTTGAGGGGAAAAACCTTCAAGCTTTTGGACGTTTTCGAGCCAATACTGCTCGGTAAAACATAATTTTAG
TGCATTGGATATAAGGTAGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 2; Pyroglutamyl-peptidase I 2; PGP-I 2; Pyrase 2 [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSVTPERV
AINQDDARISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVK
AGFMHIPYMMEQVVNRPTTPTMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH

Sequences:

>Translated_214_residues
MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSVTPERV
AINQDDARISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVK
AGFMHIPYMMEQVVNRPTTPTMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH
>Mature_214_residues
MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSVTPERV
AINQDDARISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVK
AGFMHIPYMMEQVVNRPTTPTMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23553; Mature: 23553

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQP
CEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DFVLCIGQAGGRTSVTPERVAINQDDARISDNEDNQPIDRPIRPDGASAYFSSLPIKAMV
CEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHH
QAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVKAGFMHIPYMMEQVVNRPTTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
TMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH
CHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQP
CEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DFVLCIGQAGGRTSVTPERVAINQDDARISDNEDNQPIDRPIRPDGASAYFSSLPIKAMV
CEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHH
QAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVKAGFMHIPYMMEQVVNRPTTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
TMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH
CHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]