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The map label for this gene is accC [H]

Identifier: 225852418

GI number: 225852418

Start: 898519

End: 899877

Strand: Reverse

Name: accC [H]

Synonym: BMEA_A0945

Alternate gene names: 225852418

Gene position: 899877-898519 (Counterclockwise)

Preceding gene: 225852419

Following gene: 225852417

Centisome position: 42.33

GC content: 57.62

Gene sequence:

>1359_bases
ATGTTTCAAAAGATACTCATAGCCAATCGTGGCGAAATCGCTCTTCGCGTGCTCAGGGCTTGCAAGGAGCTGGGCATAAA
GACGGTCGCCGTTCATTCCACGGCAGATGCCGACGCAATGCATGTGCGCCTGGCAGATGAGAGCGTATGCATCGGACCGC
CGCCCTCACGCGACAGCTATCTGAACATCCATCAGATCGTGGCCGCCTGCGAAATCACCGGCGCGGATGCAATTCACCCC
GGCTACGGCTTCCTTTCGGAAAATGCAAAATTCGCCGAAATCCTTGAAGCCCATGACATTACCTTCATCGGCCCCACTGC
TTCGCATATCCGCATCATGGGCGACAAGATCGAAGCCAAGCGCACCGCAAAGCGCCTCGGCATCCCGGTCGTTCCGGGTT
CGGACGGCGGCGTGACGGATGAAGTCGAAGCAGCCCGTATCGCCAAGGAAATCGGCTATCCGGTCATCATCAAGGCTTCG
GCCGGCGGCGGTGGTCGTGGCATGAAGGTCGCCCGCAGCGCGGAAGAGCTTCCGATCGCACTTGCGACGGCACGTTCTGA
AGCTGGCGCGGCCTTTGGCGACGATGCGGTCTACATCGAAAAATATCTCGAAAAACCGCGCCATATCGAAGTTCAGGTCA
TGGGGGACGGTGCGGGCAATGCCGTCCATCTGGGCGAACGCGACTGCTCGCTGCAACGCCGTCACCAGAAGGTCTGGGAA
GAGGGCAACTCCCCCGCCCTCAATGCGGAAGCGCGCGAAAAGATCGGCATGATCTGCGCCAATGCCTGCGCAGAGCTTGG
CTATCGCGGCGCAGGCACGATCGAATTTCTCTATGAAGATGGAGAATTCTATTTCATCGAAATGAATACGCGCCTTCAGG
TGGAACATCCGGTTACGGAAGCGATCACCGGCATCGATCTTGTGCATGAGCAGATTCGCGTTGCCGCAGGCCTTGGTCTT
TCGGTGAAGCAGAAGGATATCCGCTTTTCCGGCCATGCCATCGAGTGCCGTATCAATGCGGAAGATCCGCTGACCTTCGC
ACCGTCACCGGGCCTCATCACGCATTATCATACGCCGGGCGGGCTTGGCGTACGCGTCGATTCCGGCGTTTATTCCGGCT
ATCGCATTCCACCCTACTATGACAGCCTGACCGGCAAGCTCATCGTGCATGGACGTAACCGCGTCGAATGCATGATGCGT
CTGCGCCGCGCGCTGGATGAGTTCGTGGTGGATGGGGTAAAGACCACCCTGCCCCTGTTTCAGGATCTGATTTCCAATCA
GGATATCGCCAATGGCGATTATGACATCCACTGGTTGGAAAAGTACCTGGCCAACAAGAGCAAGAACGAAAGCGCCTGA

Upstream 100 bases:

>100_bases
GAAGATGCTCAGCCGGTCGAATTCGGCGAGCCGCTCGTCGTGATCGAATAAGACAGTCACGCGAAATTCGGCTTATTCAA
TGGACGGGCAGCAAAGCGCA

Downstream 100 bases:

>100_bases
AGAAAGTGACCGCAGAAGCACCCCCGGACGACGACATAATCGAGCCGGAGATGCTTCTGCGGGCCTATGCCACGGGCATA
TTTCCGATGGCCGAGGAAGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFQKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAIHP
GYGFLSENAKFAEILEAHDITFIGPTASHIRIMGDKIEAKRTAKRLGIPVVPGSDGGVTDEVEAARIAKEIGYPVIIKAS
AGGGGRGMKVARSAEELPIALATARSEAGAAFGDDAVYIEKYLEKPRHIEVQVMGDGAGNAVHLGERDCSLQRRHQKVWE
EGNSPALNAEAREKIGMICANACAELGYRGAGTIEFLYEDGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVAAGLGL
SVKQKDIRFSGHAIECRINAEDPLTFAPSPGLITHYHTPGGLGVRVDSGVYSGYRIPPYYDSLTGKLIVHGRNRVECMMR
LRRALDEFVVDGVKTTLPLFQDLISNQDIANGDYDIHWLEKYLANKSKNESA

Sequences:

>Translated_452_residues
MFQKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAIHP
GYGFLSENAKFAEILEAHDITFIGPTASHIRIMGDKIEAKRTAKRLGIPVVPGSDGGVTDEVEAARIAKEIGYPVIIKAS
AGGGGRGMKVARSAEELPIALATARSEAGAAFGDDAVYIEKYLEKPRHIEVQVMGDGAGNAVHLGERDCSLQRRHQKVWE
EGNSPALNAEAREKIGMICANACAELGYRGAGTIEFLYEDGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVAAGLGL
SVKQKDIRFSGHAIECRINAEDPLTFAPSPGLITHYHTPGGLGVRVDSGVYSGYRIPPYYDSLTGKLIVHGRNRVECMMR
LRRALDEFVVDGVKTTLPLFQDLISNQDIANGDYDIHWLEKYLANKSKNESA
>Mature_452_residues
MFQKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAIHP
GYGFLSENAKFAEILEAHDITFIGPTASHIRIMGDKIEAKRTAKRLGIPVVPGSDGGVTDEVEAARIAKEIGYPVIIKAS
AGGGGRGMKVARSAEELPIALATARSEAGAAFGDDAVYIEKYLEKPRHIEVQVMGDGAGNAVHLGERDCSLQRRHQKVWE
EGNSPALNAEAREKIGMICANACAELGYRGAGTIEFLYEDGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVAAGLGL
SVKQKDIRFSGHAIECRINAEDPLTFAPSPGLITHYHTPGGLGVRVDSGVYSGYRIPPYYDSLTGKLIVHGRNRVECMMR
LRRALDEFVVDGVKTTLPLFQDLISNQDIANGDYDIHWLEKYLANKSKNESA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=52.9411764705882, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=52.9411764705882, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=52.9411764705882, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=45.9276018099548, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=46.5324384787472, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=46.5324384787472, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=46.5324384787472, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=31.1538461538462, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679977, Length=519, Percent_Identity=29.8651252408478, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=519, Percent_Identity=29.8651252408478, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679960, Length=519, Percent_Identity=29.8651252408478, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679971, Length=519, Percent_Identity=29.8651252408478, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679974, Length=519, Percent_Identity=29.8651252408478, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=61.4699331848552, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1786216, Length=246, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.737556561086, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=434, Percent_Identity=46.5437788018433, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.6666666666667, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=28.2398452611219, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=28.2398452611219, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=28.8888888888889, Blast_Score=201, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=42.4719101123596, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=44.4444444444444, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=45.124716553288, Blast_Score=321, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.550284629981, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=488, Percent_Identity=31.1475409836066, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=48.3221476510067, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651757, Length=430, Percent_Identity=46.046511627907, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=44.9238578680203, Blast_Score=334, Evalue=7e-92,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=29.5719844357977, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=29.5719844357977, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=29.5719844357977, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=29.5719844357977, Blast_Score=218, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49181; Mature: 49181

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAIHPGYGFLSENAKFAEILEAHDITFIGPTASHIRIMGDKIEAK
EEHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RTAKRLGIPVVPGSDGGVTDEVEAARIAKEIGYPVIIKASAGGGGRGMKVARSAEELPIA
HHHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCHHHCCEE
LATARSEAGAAFGDDAVYIEKYLEKPRHIEVQVMGDGAGNAVHLGERDCSLQRRHQKVWE
EEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGNSPALNAEAREKIGMICANACAELGYRGAGTIEFLYEDGEFYFIEMNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVAAGLGLSVKQKDIRFSGHAIECRINAEDPLTFAPSPGLITHYHTPG
HHHHHHHHHHHHHHHHCCCCEEECCCEEECCCEEEEEECCCCCEEECCCCCEEEEEECCC
GLGVRVDSGVYSGYRIPPYYDSLTGKLIVHGRNRVECMMRLRRALDEFVVDGVKTTLPLF
CCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDLISNQDIANGDYDIHWLEKYLANKSKNESA
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFQKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAIHPGYGFLSENAKFAEILEAHDITFIGPTASHIRIMGDKIEAK
EEHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RTAKRLGIPVVPGSDGGVTDEVEAARIAKEIGYPVIIKASAGGGGRGMKVARSAEELPIA
HHHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCHHHCCEE
LATARSEAGAAFGDDAVYIEKYLEKPRHIEVQVMGDGAGNAVHLGERDCSLQRRHQKVWE
EEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGNSPALNAEAREKIGMICANACAELGYRGAGTIEFLYEDGEFYFIEMNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVAAGLGLSVKQKDIRFSGHAIECRINAEDPLTFAPSPGLITHYHTPG
HHHHHHHHHHHHHHHHCCCCEEECCCEEECCCEEEEEECCCCCEEECCCCCEEEEEECCC
GLGVRVDSGVYSGYRIPPYYDSLTGKLIVHGRNRVECMMRLRRALDEFVVDGVKTTLPLF
CCEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDLISNQDIANGDYDIHWLEKYLANKSKNESA
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]