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The map label for this gene is galM [H]

Identifier: 225852369

GI number: 225852369

Start: 852461

End: 853483

Strand: Direct

Name: galM [H]

Synonym: BMEA_A0895

Alternate gene names: 225852369

Gene position: 852461-853483 (Clockwise)

Preceding gene: 225852360

Following gene: 225852371

Centisome position: 40.1

GC content: 57.18

Gene sequence:

>1023_bases
GTGAATTCGGAAATCTTCGGCTATGCGCCGGACGGGCAGGTGGTCCACCGCCTCACTATCTCCAACGGGCCTTTGACCGC
AAAGATCATCAATTGGGGCGCAGCCATTCAGGATCTGCGTATGGAAGGCCACCCGGCGCCACTGGTGATCGGCTATCGCG
ATTTTGCCGATTATCCGGCACATTCCCCGCATCTGGGTGCGATTGCGGGCCGCTCGGCCAACCGTATCCGCAATGCGCGC
TTTGATCTTGATGGAACGGTTTACGAGGTGGAGCCGAACTTCTGTGGCCGCCACAATCTGCATGGCGGCAGCAAGGGGCT
CGGACACCATGTCTGGAAGATCACGGCGACCGGCCCTGATTTCGTGTCGCTTGCAACGGTTTCTCCCGATGGCGAGATGG
GCTTCCCCGGCAATCTGAATGTGAATTGCACCTATATGCTCAATGCGGATGGAACGCTGATTGTTCGGCTGGAGGCTGTG
ACCGACAGGCCAACCATATGCAATCTGCTTCACCACAGCTATTTCAATCTGGATGACGGTGGTGAGGGTGATGTTCTCGA
CCACCAATTCAAGATTGCAGGCGACGCCTATCTTCCGGTGGATGAGGCGCTTATTCCGGACGGGCGGGTTCTGCCGGTAA
AGGACACGGCTTTCGATTTCCGCGAATTCAGGCCGCTTCGTATGCAGGAAAACGGCCGTCAGGTGGCGTATGACAATAAT
TTCTGCCTTGCGGCTGCACGCGGCCCGCTGCGCCCCTGCGCTTCGGTAAAGGCCGCGCGGTCCGGCATCCGGCTTGATAT
TTCAACTACCGAACCGGGGATACAGCTCTATGCTGGCAACACCATGGCCAATGATTGCATAGGACTGACGGGCAAGCCCT
ATGGCAAACATGCTGGCTTTTGCCTTGAACCACAGATATGGCCGGGCGCGCTGGAATATCCTTATTTTCCGCAGCCGATC
CTGCGCCCGGGCGATATTTACGCACAGACCAGCCATTTTACCTTTTCGCGCGAGGAGGATTAA

Upstream 100 bases:

>100_bases
AATTCGGAAAAAAGCGGACAATATCCGCAACGCCTCTTGCGCGGCGCGCTGCGATGCGGCTTGATGCGTTTATCTCTGGA
CGGCTTACAGGCAGGCAATC

Downstream 100 bases:

>100_bases
CCGGCAAAAGTGGCGCGTGCCGTTTCCATCGGGGCGAGCGCGCCACGGATTTCCACCACGCGCGCTGCGACGAGATGCGC
TTTCCGGGCTGCTTCCACAG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNSEIFGYAPDGQVVHRLTISNGPLTAKIINWGAAIQDLRMEGHPAPLVIGYRDFADYPAHSPHLGAIAGRSANRIRNAR
FDLDGTVYEVEPNFCGRHNLHGGSKGLGHHVWKITATGPDFVSLATVSPDGEMGFPGNLNVNCTYMLNADGTLIVRLEAV
TDRPTICNLLHHSYFNLDDGGEGDVLDHQFKIAGDAYLPVDEALIPDGRVLPVKDTAFDFREFRPLRMQENGRQVAYDNN
FCLAAARGPLRPCASVKAARSGIRLDISTTEPGIQLYAGNTMANDCIGLTGKPYGKHAGFCLEPQIWPGALEYPYFPQPI
LRPGDIYAQTSHFTFSREED

Sequences:

>Translated_340_residues
MNSEIFGYAPDGQVVHRLTISNGPLTAKIINWGAAIQDLRMEGHPAPLVIGYRDFADYPAHSPHLGAIAGRSANRIRNAR
FDLDGTVYEVEPNFCGRHNLHGGSKGLGHHVWKITATGPDFVSLATVSPDGEMGFPGNLNVNCTYMLNADGTLIVRLEAV
TDRPTICNLLHHSYFNLDDGGEGDVLDHQFKIAGDAYLPVDEALIPDGRVLPVKDTAFDFREFRPLRMQENGRQVAYDNN
FCLAAARGPLRPCASVKAARSGIRLDISTTEPGIQLYAGNTMANDCIGLTGKPYGKHAGFCLEPQIWPGALEYPYFPQPI
LRPGDIYAQTSHFTFSREED
>Mature_340_residues
MNSEIFGYAPDGQVVHRLTISNGPLTAKIINWGAAIQDLRMEGHPAPLVIGYRDFADYPAHSPHLGAIAGRSANRIRNAR
FDLDGTVYEVEPNFCGRHNLHGGSKGLGHHVWKITATGPDFVSLATVSPDGEMGFPGNLNVNCTYMLNADGTLIVRLEAV
TDRPTICNLLHHSYFNLDDGGEGDVLDHQFKIAGDAYLPVDEALIPDGRVLPVKDTAFDFREFRPLRMQENGRQVAYDNN
FCLAAARGPLRPCASVKAARSGIRLDISTTEPGIQLYAGNTMANDCIGLTGKPYGKHAGFCLEPQIWPGALEYPYFPQPI
LRPGDIYAQTSHFTFSREED

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=345, Percent_Identity=39.4202898550725, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI1786971, Length=349, Percent_Identity=34.0974212034384, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17557428, Length=321, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI115533334, Length=321, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322004, Length=335, Percent_Identity=28.6567164179104, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324399, Length=333, Percent_Identity=27.6276276276276, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24659048, Length=352, Percent_Identity=32.6704545454545, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24668278, Length=357, Percent_Identity=33.0532212885154, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=31.7647058823529, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583720, Length=346, Percent_Identity=31.5028901734104, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24641876, Length=364, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37265; Mature: 37265

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEIFGYAPDGQVVHRLTISNGPLTAKIINWGAAIQDLRMEGHPAPLVIGYRDFADYPA
CCCCEEEECCCCCEEEEEEECCCCEEEEEEECCHHHHHHHCCCCCCCEEEEEHHHCCCCC
HSPHLGAIAGRSANRIRNARFDLDGTVYEVEPNFCGRHNLHGGSKGLGHHVWKITATGPD
CCCCCCEEECCCHHHHCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCC
FVSLATVSPDGEMGFPGNLNVNCTYMLNADGTLIVRLEAVTDRPTICNLLHHSYFNLDDG
EEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCC
GEGDVLDHQFKIAGDAYLPVDEALIPDGRVLPVKDTAFDFREFRPLRMQENGRQVAYDNN
CCCCEECCEEEEECCEECCCCHHCCCCCCEEEECCCCCCHHHCCCCEECCCCCEEEECCC
FCLAAARGPLRPCASVKAARSGIRLDISTTEPGIQLYAGNTMANDCIGLTGKPYGKHAGF
EEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCEECCCCCCCCCCCCE
CLEPQIWPGALEYPYFPQPILRPGDIYAQTSHFTFSREED
EECCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCC
>Mature Secondary Structure
MNSEIFGYAPDGQVVHRLTISNGPLTAKIINWGAAIQDLRMEGHPAPLVIGYRDFADYPA
CCCCEEEECCCCCEEEEEEECCCCEEEEEEECCHHHHHHHCCCCCCCEEEEEHHHCCCCC
HSPHLGAIAGRSANRIRNARFDLDGTVYEVEPNFCGRHNLHGGSKGLGHHVWKITATGPD
CCCCCCEEECCCHHHHCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCC
FVSLATVSPDGEMGFPGNLNVNCTYMLNADGTLIVRLEAVTDRPTICNLLHHSYFNLDDG
EEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCC
GEGDVLDHQFKIAGDAYLPVDEALIPDGRVLPVKDTAFDFREFRPLRMQENGRQVAYDNN
CCCCEECCEEEEECCEECCCCHHCCCCCCEEEECCCCCCHHHCCCCEECCCCCEEEECCC
FCLAAARGPLRPCASVKAARSGIRLDISTTEPGIQLYAGNTMANDCIGLTGKPYGKHAGF
EEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCEECCCCCCCCCCCCE
CLEPQIWPGALEYPYFPQPILRPGDIYAQTSHFTFSREED
EECCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]