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The map label for this gene is purL

Identifier: 225852350

GI number: 225852350

Start: 835200

End: 837422

Strand: Reverse

Name: purL

Synonym: BMEA_A0876

Alternate gene names: 225852350

Gene position: 837422-835200 (Counterclockwise)

Preceding gene: 225852351

Following gene: 225852349

Centisome position: 39.4

GC content: 59.11

Gene sequence:

>2223_bases
ATGACTATTTCCAATACGCGAGACATCACGCCGGAACTGATCGAAGCGCATGGTCTTAAGCCGGACGAGTATCAGCGCAT
TCTTGAGCTGATCGGGCGCGAGCCGACTTTTACCGAACTCGGCATTTTCTCCGCCATGTGGAATGAGCACTGCTCCTACA
AGTCCTCCAAGAAATGGCTACGCACACTTCCGACCAGCGGACCGCGCGTCATTCAAGGCCCCGGTGAAAATGCAGGCGTG
GTCGATATTGGCGATGGCGATTGCGTCGTCTTCAAGATGGAAAGCCACAATCACCCCTCCTATATCGAGCCTTATCAGGG
TGCCGCGACCGGCGTGGGCGGAATCTTGCGCGACGTGTTCACCATGGGCGCGCGCCCCGTTGCGGCAATGAATGCGCTGC
GCTTTGGCGAACCCGACCATCCAAAAACCCGCCACCTCGTCTCGGGCGTTGTTTCCGGCGTCGGCGGCTATGGCAATGCC
TTCGGCGTGCCGACTGTCGGTGGCGAGGTGAATTTCGACAAGCGCTATAACGGCAATATCCTCGTCAATGCCTTTGCTGC
CGGTCTTGCCCGGCATGATGGCATTTTCCTGTCGGAAGCCGAGGGCGTCGGCCTGCCGGTCGTCTATCTGGGTGCAAAGA
CTAGCCGCGATGGTGTTGGCGGCGCAACAATGGCATCGGCTGAATTCGACGAGTCGATCGAGGAAAAGCGCCCCACCGTT
CAGGTGGGCGATCCTTTCACCGAAAAATGCCTGCTTGAAGCCTGCCTTGAACTCATGGCTTCCGGTGCGGTCATCGCCAT
TCAGGACATGGGCGCTGCCGGCCTCACCTGCTCGGCGGTCGAGATGGGTGCCAAGGGCGATCTCGGCATCGAACTCATTC
TCGACCATGTTCCCGTTCGCGAAGAGAACATGACCGCCTATGAAATGATGCTTTCGGAAAGCCAGGAGCGCATGCTCATG
GTGCTGAAGCCGGAAAAGGAAGCAGAAGCGCAGGCTATCTTCCGCAAATGGGGCCTTGATTTCGCGATTGTCGGCAAGAC
CACGGACGATCTTCGTTTCCGCGTCATCCATCAGGGGGAAGAGGTCGCCAATCTGCCGATCAAGGATCTGGGCGACGAAG
CGCCGGAATATGATCGCCCGTGGATGGAGCCGGGCAAGCATGCGCCGCTGCCTGCCAGCAATGTGCCGCAGGTGGAAGAC
TATTCCGCAGCCCTGCTGAAGCTGATCGGCTCGCCCGATCTTTCCTCGCGCCGCTGGGTCTATGAACAGTACGACACGCT
CATTCAGGGCAATTCCTTGCAGGTTCCGGGCGGCGACGCCGGTGTAATCCGTGTCGAAGGCCATGAAACCAAGGCTCTCG
CCTTCTCTTCCGACGTGACGCCGCGCTATTGCGAAGCCGATCCGTTTGAAGGCGGCAAGCAGGCCGTTGCCGAATGCTGG
CGCAACATCACGGCGACCGGCGCGGAGCCGCTGGCCTCGACCGATAATCTGAACTTCGGCAATCCCGAAAAGCCGGAAAT
CATGGGCCAGCTCGTCAAGGCTATCGAAGGCATTGGCGAGGCCTGCCGCGCACTCGACTTCCCGATCGTGTCCGGCAATG
TGTCGCTTTACAATGAGACCAACGGCCAGGCCATTCTGCCAACGCCAACGATTGCGGGTGTTGGCCTCCTTCCCGACTGG
TCGCAAATGGCGAAGATCGGCGGCATGCAGGATGGCGATACGCTGGTTCTGCTCGGTGGTGACGGAACGCATCTCGGCCA
GTCGGTCTATCTGCGTGACCTTTTCGACCGCGCGGACGGTCCTGCGCCTTTTGTCGATCTGGCGCTTGAAAAGCGCAATG
GCGAATTTGTCCGTTCTGCCATTCGCAACGGTCAGGTGACGGCCTGCCATGATCTTTCCGATGGCGGTCTGGCGATTGCC
GTTGCCGAAATGGCGATCAAGTCCGGCAAAGGTGCGACGCTGGACGCTGGTGACGGCCTGCCGCACGCCCTGCTTTTCGG
TGAAGATCAGGCACGCTATGTTATTTCCGCCACGCCTGAAATGGCAAAGCTCATCGCGCTTAACGCGGAAGGCGCAGGCG
TTCCATTCCGCATTTTGGGTACAGTTGGCGGCGACCGGCTGAAAATCAGCAAGAATGTCGATGTCAGCGTGGCCGATCTG
ACGCAGGCTTATGAAGGTTGGTTCCCGAACTTCATGAACGGCGAACTGACCGGCAATAACTGA

Upstream 100 bases:

>100_bases
CATGAAAACATAGGTTAAAGAGGCGCCTTGAAACCTTAGGCGCCAGTCTTCGGCAGAAGGCTTTCGGGTGCCACAGCCTG
CGACGGGGTTCCCCATTTCC

Downstream 100 bases:

>100_bases
TCTTATCCTTGGAGCGGTTCCTGTTTTAACAGGATCGCCGGAACCGCTCTGACTGTTTGTTTTATCGCATTGTCCAACGC
AAAACCGTTTCACGCTTTTG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNA
FGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLM
VLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVED
YSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDW
SQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIA
VAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
TQAYEGWFPNFMNGELTGNN

Sequences:

>Translated_740_residues
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNA
FGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLM
VLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVED
YSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDW
SQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIA
VAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
TQAYEGWFPNFMNGELTGNN
>Mature_739_residues
TISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGVV
DIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAF
GVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTVQ
VGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLMV
LKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDY
SAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECWR
NITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDWS
QMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAV
AEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADLT
QAYEGWFPNFMNGELTGNN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=672, Percent_Identity=22.7678571428571, Blast_Score=84, Evalue=6e-16,
Organism=Escherichia coli, GI48994899, Length=806, Percent_Identity=23.3250620347395, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=442, Percent_Identity=23.3031674208145, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=742, Percent_Identity=23.8544474393531, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24582111, Length=753, Percent_Identity=23.3731739707835, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24582109, Length=753, Percent_Identity=23.3731739707835, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137292, Length=753, Percent_Identity=23.3731739707835, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_BRUA1 (B2S573)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934794.1
- ProteinModelPortal:   B2S573
- SMR:   B2S573
- GeneID:   6327960
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I07990
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79148; Mature: 79017

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNI
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEEEECCCCC
EENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGE
CCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCC
EVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWV
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADG
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGL
CCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCEEECCCCC
PHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
CEEEEECCCCCCEEEECCHHHEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEHHHH
TQAYEGWFPNFMNGELTGNN
HHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNI
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LVNAFAAGLARHDGIFLSEAEGVGLPVVYLGAKTSRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEEEECCCCC
EENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGE
CCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCC
EVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWV
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADG
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGL
CCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCEEECCCCC
PHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
CEEEEECCCCCCEEEECCHHHEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEHHHH
TQAYEGWFPNFMNGELTGNN
HHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA