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The map label for this gene is bcr [H]

Identifier: 225852346

GI number: 225852346

Start: 832644

End: 833909

Strand: Reverse

Name: bcr [H]

Synonym: BMEA_A0872

Alternate gene names: 225852346

Gene position: 833909-832644 (Counterclockwise)

Preceding gene: 225852348

Following gene: 225852342

Centisome position: 39.23

GC content: 58.21

Gene sequence:

>1266_bases
ATGCCGCTCGACATCAAGGACGGTTCGCCAAGCCATCAGACATCCATACGCGGACGCGGTGAATTTATTGCGCTCATCGC
CGCCATCATGGCTATCAATGCCCTCGCTGTCGATATCATGTTGCCGGGCCTGCCGCAGATCGGCGCCAGCCTCGGTGTAC
ATTCTGAAAATCATGTTCAGTTCGTAATCACGGCCTATCTGCTGGGTTTCGGTGTTTCGCAGCTTTTCTATGGCCCATTG
AGCGACCGTTTCGGGCGCAGGCTGCCGCTTTTCGGCGGTCTGGCCATCTATGTTGTCGCCGCACTGGGCTCTGCCTTTGT
AACCGACTTCACGACGCTCATCATTCTGCGTGTGCTGCAAGGGCTTGGCGCTGCCGCAACGCGCGTGATTGCCGTGTCCG
TCGTTCGCGACAAGTTTTCCGGCCGCCAGATGGCGGAAGTCATGTCGCTTGTCATGATGGTTTTCATGATCCTTCCGGTC
GTGGCGCCCGCCACCGGCCAGCTCATCATGCTGTTCGGCGAATGGCACCTGATCTTCATGTTCATGGCCATTATGGCGCT
TGTCGTCGGCCTGTGGGCATTCCTTCGCCTGCCGGAGACGCTCCCCGTGAGCCATCGCCGCCCGCTCACCATGAAAAGTA
CGCTTGGCGGTTTCGTGATTGTCCTTACGAACCGCGTGGCGCTGTTCTATATGCTGGGGACCTCGTTCATTCTCGGCGCC
CTCTTCGGCTATATCAATTCCGCACAGCAGATTTTTGTCGGCATCTATCAGCTCGGTACATTATTCCCGCTGGCCTTTGC
CGCCGTGGCCATGACGCTTGCGCTTGCCTCGTTCCTGAATTCGCGGCTGGTGGGGCGCTTCGGGATGCGGCGCATTTCCC
AGACCATGCTGCTCGTTTTCACGAGCTTCAGCCTTCTCTGGATGGTGCTGTCTATCGTCATGGATGGCCCCATTCCATTT
GCGGTTCTGATGATAATCTATATGACCATCATGCTCTCGTTCAGCCTTGTGACCGCCAATTTCAATGCGCTGGCCATGGA
ACCCCTGGGCGAAGTGGCTGGCACGGCTTCTTCCGTGCTGGGCTTCGCACAGACCGTCATCGGCGCGGCACTCGGCGCGG
TGATAGGACAGGCTTTCGACGGCACCACCACGCCCGTTGCCACCGGCTATTGCGTGCTCGGTTTCGTGGCGCTTGCCTGT
GTGCTTATCGCCGAACGCGGACGGTTGTTCAGGGTTCAAAATCCGCCAGCCGAACATGTGATCTAA

Upstream 100 bases:

>100_bases
AGCGGCTGCGCGCACAAAGGTCCGGCAAGCCGCTCTGGGATCTTTATTCCGCGCTGCACCTTTCTGAGGCGGCGCACCAA
TATGCCAGGGAATGCCAGCC

Downstream 100 bases:

>100_bases
TCACCCTTCGCAAATGTAAAAGCCCGCCTGACCGGCGGGCTCAGACTGCTGACAAACCTCGGGCAGGGTCAAAATGGCCT
CAGATTCACGGAACGTCACA

Product: drug resistance transporter, Bcr/CflA subfamily protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MPLDIKDGSPSHQTSIRGRGEFIALIAAIMAINALAVDIMLPGLPQIGASLGVHSENHVQFVITAYLLGFGVSQLFYGPL
SDRFGRRLPLFGGLAIYVVAALGSAFVTDFTTLIILRVLQGLGAAATRVIAVSVVRDKFSGRQMAEVMSLVMMVFMILPV
VAPATGQLIMLFGEWHLIFMFMAIMALVVGLWAFLRLPETLPVSHRRPLTMKSTLGGFVIVLTNRVALFYMLGTSFILGA
LFGYINSAQQIFVGIYQLGTLFPLAFAAVAMTLALASFLNSRLVGRFGMRRISQTMLLVFTSFSLLWMVLSIVMDGPIPF
AVLMIIYMTIMLSFSLVTANFNALAMEPLGEVAGTASSVLGFAQTVIGAALGAVIGQAFDGTTTPVATGYCVLGFVALAC
VLIAERGRLFRVQNPPAEHVI

Sequences:

>Translated_421_residues
MPLDIKDGSPSHQTSIRGRGEFIALIAAIMAINALAVDIMLPGLPQIGASLGVHSENHVQFVITAYLLGFGVSQLFYGPL
SDRFGRRLPLFGGLAIYVVAALGSAFVTDFTTLIILRVLQGLGAAATRVIAVSVVRDKFSGRQMAEVMSLVMMVFMILPV
VAPATGQLIMLFGEWHLIFMFMAIMALVVGLWAFLRLPETLPVSHRRPLTMKSTLGGFVIVLTNRVALFYMLGTSFILGA
LFGYINSAQQIFVGIYQLGTLFPLAFAAVAMTLALASFLNSRLVGRFGMRRISQTMLLVFTSFSLLWMVLSIVMDGPIPF
AVLMIIYMTIMLSFSLVTANFNALAMEPLGEVAGTASSVLGFAQTVIGAALGAVIGQAFDGTTTPVATGYCVLGFVALAC
VLIAERGRLFRVQNPPAEHVI
>Mature_420_residues
PLDIKDGSPSHQTSIRGRGEFIALIAAIMAINALAVDIMLPGLPQIGASLGVHSENHVQFVITAYLLGFGVSQLFYGPLS
DRFGRRLPLFGGLAIYVVAALGSAFVTDFTTLIILRVLQGLGAAATRVIAVSVVRDKFSGRQMAEVMSLVMMVFMILPVV
APATGQLIMLFGEWHLIFMFMAIMALVVGLWAFLRLPETLPVSHRRPLTMKSTLGGFVIVLTNRVALFYMLGTSFILGAL
FGYINSAQQIFVGIYQLGTLFPLAFAAVAMTLALASFLNSRLVGRFGMRRISQTMLLVFTSFSLLWMVLSIVMDGPIPFA
VLMIIYMTIMLSFSLVTANFNALAMEPLGEVAGTASSVLGFAQTVIGAALGAVIGQAFDGTTTPVATGYCVLGFVALACV
LIAERGRLFRVQNPPAEHVI

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=361, Percent_Identity=30.4709141274238, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790146, Length=352, Percent_Identity=30.1136363636364, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082312, Length=366, Percent_Identity=27.8688524590164, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994889, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790794, Length=198, Percent_Identity=28.2828282828283, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324264, Length=168, Percent_Identity=30.952380952381, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45202; Mature: 45071

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
PLDIKDGSPSHQTSIRGRGEFIALIAAIMAINALAVDIMLPGLPQIGASLGVHSENHVQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
FVITAYLLGFGVSQLFYGPLSDRFGRRLPLFGGLAIYVVAALGSAFVTDFTTLIILRVLQ
HHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGAAATRVIAVSVVRDKFSGRQMAEVMSLVMMVFMILPVVAPATGQLIMLFGEWHLIFM
HCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHH
FMAIMALVVGLWAFLRLPETLPVSHRRPLTMKSTLGGFVIVLTNRVALFYMLGTSFILGA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCEEEEHHHHHHHHHHHHHHHHHHH
LFGYINSAQQIFVGIYQLGTLFPLAFAAVAMTLALASFLNSRLVGRFGMRRISQTMLLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSFSLLWMVLSIVMDGPIPFAVLMIIYMTIMLSFSLVTANFNALAMEPLGEVAGTASSVL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GFAQTVIGAALGAVIGQAFDGTTTPVATGYCVLGFVALACVLIAERGRLFRVQNPPAEHV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]