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The map label for this gene is purM [H]

Identifier: 225852231

GI number: 225852231

Start: 716409

End: 717488

Strand: Reverse

Name: purM [H]

Synonym: BMEA_A0748

Alternate gene names: 225852231

Gene position: 717488-716409 (Counterclockwise)

Preceding gene: 225852232

Following gene: 225852230

Centisome position: 33.75

GC content: 60.74

Gene sequence:

>1080_bases
ATGACCATGGAAAACAAGCCCGCCGGCCAAAACGGCCTGACCTATGCGCAGGCTGGTGTTGATATCGATGCCGGCAACCT
GATGGTCGAAAAGATCAAGCCATTGGTGCGCTCGACACGCCGCCCCGGTGCGGATGGCGAAATCGGCGGGTTCGGCGGTT
TGTTCGATCTCAAGGCTGCGGGCTTCAAAGGTCCGGTTCTGGTTGCGGCCAATGATGGTGTCGGCACCAAGCTCAAGATC
GCTATTGATGCGGATATCCATGATACTGTCGGCATCGATCTCGTGGCGATGTGCGTGAACGATCTGGTCGTGCAGGGCGC
GGAACCGCTTTTCTTTCTCGATTATTACGCCACCGGCAAGCTTTCGCCGGATCAGGGCGTCGCGATCGTTTCGGGCATCG
CGGAAGGCTGCCGTCAGGCGGGCTGCGCACTGATCGGCGGTGAGACGGCGGAAATGCCGGGCATGTATCGCGACGGCGAT
TACGATCTTGCAGGTTTTGCCGTGGGCGCAGCAGAACGTGACCGCCTGCTGCCGCGCGGCGATATTGCCGAAGGCGACAT
CATTCTGGGCCTTGCTTCCTCGGGCGTTCATTCCAACGGCTTCTCGCTTGTGCGCCGCATCGTCGAGCTTTCCGGCCTCG
GCTGGAAGTCGCAGGCCCCTTTCCAACCGGGCGCAACGCTCGGTGAAGCCCTGCTCACCCCGACGCGGATTTACGTCAAG
CCGCTGCTCGCCGCCATCCGTGCCTGCGACGGCATCAAGGCGCTGGCGCATATTACAGGCGGCGGCTTCCCCGACAATAT
TCCCCGCGTCCTGCCGAAAGGCCTGGCTGCGGAGATTGATCTTCCGGCCATTGCAGTCCCGCCGGTTTTCTCCTGGCTTG
CCAAGACTGGCAATGTCGAACCGAATGAAATGCTGCGCACCTTCAATTGCGGCATCGGCATGATTGCGGTCGTCAATCCG
GCAAAGGTCGATGAAGTGATCGCAGCACTTGCAGCCGAAGGCGAAAAGGTCGTTACACTCGGCCGCATGACCCGGCGTGA
GAAAGACGGCGTCATCTACAAGGGCCAGCTCGCACTATGA

Upstream 100 bases:

>100_bases
TTCGCTTTTCCCGCCCCCCGGCCTTGCAGGACGGGCCATCTCGTGCCATTGCGCGCTAACAAATACAGCGTGGACAAGCA
CCCAGTTTCAGGAGCACGCC

Downstream 100 bases:

>100_bases
AACGCAACCGGGTCGTCATCTTTATTTCAGGCGGCGGCTCCAACATGGAAGCGCTGATCCGCGCGGCACAAGCGCCCGGT
TTTCCGGCGGAAATCGTAGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKGPVLVAANDGVGTKLKI
AIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGD
YDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVK
PLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNP
AKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL

Sequences:

>Translated_359_residues
MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKGPVLVAANDGVGTKLKI
AIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGD
YDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVK
PLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNP
AKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
>Mature_358_residues
TMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKGPVLVAANDGVGTKLKIA
IDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDY
DLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKP
LLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPA
KVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=55.6547619047619, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=55.6547619047619, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=55.6547619047619, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=55.7228915662651, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567511, Length=340, Percent_Identity=44.7058823529412, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6321203, Length=351, Percent_Identity=55.2706552706553, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24582400, Length=271, Percent_Identity=51.6605166051661, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37390; Mature: 37258

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAA
CCCCCCCCCCCCCEEEECCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCC
GFKGPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGK
CCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
LSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRG
CCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCCEEEEEECCHHHHCCCCCC
DIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVK
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHH
PLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVE
HHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHCCCCCEECCCCCEEHHHHHHHHHHCCCCC
PNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCEEECEECC
>Mature Secondary Structure 
TMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAA
CCCCCCCCCCCCEEEECCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCC
GFKGPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGK
CCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
LSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRG
CCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCCEEEEEECCHHHHCCCCCC
DIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVK
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHH
PLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVE
HHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHCCCCCEECCCCCEEHHHHHHHHHHCCCCC
PNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCEEECEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA