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The map label for this gene is fsr [H]

Identifier: 225852177

GI number: 225852177

Start: 667712

End: 668923

Strand: Reverse

Name: fsr [H]

Synonym: BMEA_A0693

Alternate gene names: 225852177

Gene position: 668923-667712 (Counterclockwise)

Preceding gene: 225852186

Following gene: 225852171

Centisome position: 31.47

GC content: 59.24

Gene sequence:

>1212_bases
ATGAGCGTGAGTGCTGCGCAGCAGCCATCGAACAGCAGTGCGGACAATACCGTCCTCACGATCATTCTGGCCACAAGCCT
GGGCCATTTCCTGAACGACATGATGCAGTCGCTTCTTCCGGCCATCTATCCGATGCTGAAGGAGAATTATAGCCTGTCCT
TCTGGCAGATCGGCCTTCTCACCTTCACGTTCCAGATGACGGCCTCCATCCTGCAACCGCTCGTGGGCATCTATACCGAC
CGCAAGCCGATGCCCTATTCACTGACATTCGGCATGGGTTGCACCTTGATCGGCCTCGTCTTTCTGGCGACAGCGCATCA
TTATTCATTCCTGCTGCTGGGCGCGGCCTGCGTGGGCTTCGGCTCTTCCGTGTTCCACCCGGAAGCGGCGCGTGTAGCCC
GCCTGGCATCGGGCGGACGCCATGGTTTCGCGCAATCGCTGTTCCAGGTGGGCGGCAATTTCGGCTCGTCCATCGGGCCT
TTGCTTGCCGCCTTCATCGTGCTGCCCTTCGGCCAGATCAGCGTATCGTGGTTCTCGGTCGCAGCCCTGATCGGCATGTT
CGTGCTATGGTATGTCGGCAACTGGTATAATCGCTACCGCCTTGCCAATGCCAACAAGCCCAAGCCCGACAAGACCTTGC
CGCTGCCGCGCAACAGGGTGATCGCCTCCGTCGCCGTTCTGGCCTTGCTCGTCTTCACCAAATATATCTACATGGCCAGC
CTGACGAGTTATTACACCTTCTACACGATCAGCCATTTCGGCGTGTCGGTGCAGACCTCGCAGCTTCTCCTGTTCCTGTT
TCTGGGGGCGGTCGCGGCCGGGACCATCATCGGCGGCCCCATTGGCGACAAGATCGGCGCGCGCAAGGTGATCTGGGCTT
CCATTCTGGGCGTATTGCCCTTCACGCTCGCACTGCCCTATGCAAACCTTGAAATGACAGCGGTGCTGACGATCATCATC
GGCCTCATTCTCGCTTCCGCATTCCCGGCCATCATCGTGTTCGCGCAGGAACTGCTTCCCGGACGTGTCGGTATGCTTTC
AGGACTGTTCTTCGGCTTCGCCTTCGGCATGGCAGGCATCGCCGCCGCCGTTCTCGGTATCGTGGCTGACCAGAAAGGCA
TCGAGTTCGTCTACAGGATCTGCTCTTACCTGCCGTTCCTGGGGCTCTTGACCATCTTTCTTCCGAAGCTGGAACGCCGC
CGCAAGGCCTGA

Upstream 100 bases:

>100_bases
ATCTTACCCTGCAAGTTACCTTGAGTGCCTGTTTCCTTCCTGTTCGACAGACCGATGGGGAACGTGCCTGAAGCCTGGCT
TTCATCTTCGGAGTAGCAAT

Downstream 100 bases:

>100_bases
GAAAAACGCCCCGCCAAAAAGCAAAGAGCGGTTCCGGCATAACCGAAACCGCTCTGATCTAGTGGAGCACCGCCCGTCCC
CCAACGTGCGGTGCTCCCAT

Product: major facilitator superfamily protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLLTFTFQMTASILQPLVGIYTD
RKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGFGSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGP
LLAAFIVLPFGQISVSWFSVAALIGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMAS
LTSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGVLPFTLALPYANLEMTAVLTIII
GLILASAFPAIIVFAQELLPGRVGMLSGLFFGFAFGMAGIAAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERR
RKA

Sequences:

>Translated_403_residues
MSVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLLTFTFQMTASILQPLVGIYTD
RKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGFGSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGP
LLAAFIVLPFGQISVSWFSVAALIGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMAS
LTSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGVLPFTLALPYANLEMTAVLTIII
GLILASAFPAIIVFAQELLPGRVGMLSGLFFGFAFGMAGIAAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERR
RKA
>Mature_402_residues
SVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLLTFTFQMTASILQPLVGIYTDR
KPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGFGSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGPL
LAAFIVLPFGQISVSWFSVAALIGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMASL
TSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGVLPFTLALPYANLEMTAVLTIIIG
LILASAFPAIIVFAQELLPGRVGMLSGLFFGFAFGMAGIAAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERRR
KA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=407, Percent_Identity=59.95085995086, Blast_Score=455, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43549; Mature: 43418

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TFTFQMTASILQPLVGIYTDRKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGPLLAAFIVLPFGQISVSWFSV
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AALIGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMAS
HHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGVLP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
FTLALPYANLEMTAVLTIIIGLILASAFPAIIVFAQELLPGRVGMLSGLFFGFAFGMAGI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERRRKA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVSAAQQPSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TFTFQMTASILQPLVGIYTDRKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSSVFHPEAARVARLASGGRHGFAQSLFQVGGNFGSSIGPLLAAFIVLPFGQISVSWFSV
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AALIGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMAS
HHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTSYYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGVLP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
FTLALPYANLEMTAVLTIIIGLILASAFPAIIVFAQELLPGRVGMLSGLFFGFAFGMAGI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAAVLGIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERRRKA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]