Click here to switch to the map view.

The map label for this gene is arnA [H]

Identifier: 225852053

GI number: 225852053

Start: 536695

End: 537474

Strand: Reverse

Name: arnA [H]

Synonym: BMEA_A0555

Alternate gene names: 225852053

Gene position: 537474-536695 (Counterclockwise)

Preceding gene: 225852054

Following gene: 225852046

Centisome position: 25.28

GC content: 45.13

Gene sequence:

>780_bases
ATGGCGATTGCACCAAATACACGCGTTTTGGTAGCAGGTTACGGATTGCCGGCGGAATTTTGCGTTACAACCTTGATTGG
CATGGGCGTAGAGATTGATAAGATTGCGGTTGCGACGCATAGAGAAGACAATCGTAATTGTGGTTTACATTCCATGTTAA
GGCTTAGGAACATTCAATTCACTACCGCAGCTGCAAATTCGGAAGAATTCTACGAATTTGGAGCTAATTTCGATCCGGAC
ATGATTATAAGCATGCACTATCGATCGTTAATCCCGGGTCGCTTCCTAAAATTGGCAAAAAAGGGGAGCGTAAATCTTCA
TCCGTCGCTTCTTCCTGCTTATCGCGGAACAAACTCGGTTGCGTGGGTGATTATAAATGGCGAGAGCGAAACCGGTTTCA
GCTATCATCGTATGGACGAAAATTTCGATACGGGTGCAATATTGTTGCAAGAGCGAATTTCAGTTGAAGAAACCGATACA
GCCTTTTCTTTATTTCACCGACAAATTGCGCGCGCGATGCTGCGCTTAGAGGAAGTCATCCTTAAACTAGATCAAGGAGA
TCCGGGATTTGCTCAATTGGGTGAAGCTAGCTATTACGCCCGCGAACTTCCTTTCGGTGGCGTTATCGACCCAAGATGGT
CGGAAGTCCAGATTGATCGTTTTATCCGAGCAATGTTCTTTCCTCCGTTCCCACCGGCAGTATTGAAGATTGATGGCAAG
GTATATTATGTTCCTTCTATAGATATTTACCGCTCTCTTATGAGGGGTATTCCCTCGTAA

Upstream 100 bases:

>100_bases
GTACGAATTGCAGCGCGAACTGTACGAACGTTACCCAAGTTGGAATGCAGTCGCGGGTGAGTATTTACGCATAGTAACTG
ACGAAAAAGAGGCATTTTAA

Downstream 100 bases:

>100_bases
AATGGCTTGTTGCTTGTTTAGGTTTTTGGTCCCAGCAGGTGATGGTGTAGTTTGATGATAAAGGCTTCTGGCTTTGATTT
CCAAAGTTCCTGAATGGCTT

Product: bifunctional polymyxin resistance protein ArnA

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAIAPNTRVLVAGYGLPAEFCVTTLIGMGVEIDKIAVATHREDNRNCGLHSMLRLRNIQFTTAAANSEEFYEFGANFDPD
MIISMHYRSLIPGRFLKLAKKGSVNLHPSLLPAYRGTNSVAWVIINGESETGFSYHRMDENFDTGAILLQERISVEETDT
AFSLFHRQIARAMLRLEEVILKLDQGDPGFAQLGEASYYARELPFGGVIDPRWSEVQIDRFIRAMFFPPFPPAVLKIDGK
VYYVPSIDIYRSLMRGIPS

Sequences:

>Translated_259_residues
MAIAPNTRVLVAGYGLPAEFCVTTLIGMGVEIDKIAVATHREDNRNCGLHSMLRLRNIQFTTAAANSEEFYEFGANFDPD
MIISMHYRSLIPGRFLKLAKKGSVNLHPSLLPAYRGTNSVAWVIINGESETGFSYHRMDENFDTGAILLQERISVEETDT
AFSLFHRQIARAMLRLEEVILKLDQGDPGFAQLGEASYYARELPFGGVIDPRWSEVQIDRFIRAMFFPPFPPAVLKIDGK
VYYVPSIDIYRSLMRGIPS
>Mature_258_residues
AIAPNTRVLVAGYGLPAEFCVTTLIGMGVEIDKIAVATHREDNRNCGLHSMLRLRNIQFTTAAANSEEFYEFGANFDPDM
IISMHYRSLIPGRFLKLAKKGSVNLHPSLLPAYRGTNSVAWVIINGESETGFSYHRMDENFDTGAILLQERISVEETDTA
FSLFHRQIARAMLRLEEVILKLDQGDPGFAQLGEASYYARELPFGGVIDPRWSEVQIDRFIRAMFFPPFPPAVLKIDGKV
YYVPSIDIYRSLMRGIPS

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=115, Percent_Identity=36.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21614513, Length=79, Percent_Identity=37.9746835443038, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788589, Length=244, Percent_Identity=31.5573770491803, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789683, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI133930964, Length=172, Percent_Identity=33.1395348837209, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585660, Length=78, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 29129; Mature: 28998

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAPNTRVLVAGYGLPAEFCVTTLIGMGVEIDKIAVATHREDNRNCGLHSMLRLRNIQF
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEHEEEEEECCCCCCCCCHHHHHHHHCCEE
TTAAANSEEFYEFGANFDPDMIISMHYRSLIPGRFLKLAKKGSVNLHPSLLPAYRGTNSV
EEECCCCHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCE
AWVIINGESETGFSYHRMDENFDTGAILLQERISVEETDTAFSLFHRQIARAMLRLEEVI
EEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLDQGDPGFAQLGEASYYARELPFGGVIDPRWSEVQIDRFIRAMFFPPFPPAVLKIDGK
HHCCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCE
VYYVPSIDIYRSLMRGIPS
EEEECCHHHHHHHHHCCCC
>Mature Secondary Structure 
AIAPNTRVLVAGYGLPAEFCVTTLIGMGVEIDKIAVATHREDNRNCGLHSMLRLRNIQF
CCCCCCEEEEEECCCCHHHHHHHHHHCCCEEHEEEEEECCCCCCCCCHHHHHHHHCCEE
TTAAANSEEFYEFGANFDPDMIISMHYRSLIPGRFLKLAKKGSVNLHPSLLPAYRGTNSV
EEECCCCHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCE
AWVIINGESETGFSYHRMDENFDTGAILLQERISVEETDTAFSLFHRQIARAMLRLEEVI
EEEEEECCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKLDQGDPGFAQLGEASYYARELPFGGVIDPRWSEVQIDRFIRAMFFPPFPPAVLKIDGK
HHCCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCE
VYYVPSIDIYRSLMRGIPS
EEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12219091 [H]