BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome I, complete sequence.
Accession	NC_012441
Length	2,125,701

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The map label for this gene is yciK [H]

Identifier: 225851981

GI number: 225851981

Start: 465745

End: 466485

Strand: Reverse

Name: yciK [H]

Synonym: BMEA_A0479

Alternate gene names: 225851981

Gene position: 466485-465745 (Counterclockwise)

Preceding gene: 225851982

Following gene: 225851975

Centisome position: 21.94

GC content: 61.0

Gene sequence:

>741_bases
ATGAATATCGATCTTACGGGCCGCCTCGCGCTGGTAACGGGCGCATCGCGCGGTATTGGCTATTTCCTTTCGCTTGAACT
GGCAAAACGCGGCGCGCATGTGATCGCCGTCGCCCGCACGGTTGGCGGCCTGGAAGAGCTGGACGACGAAATACGCAAGC
TTGGCAGCAGCGCCACACTGGTTCCACTCGATATCACGGATATGGAAGCCCTCGACCGCCTCGGCGGAACCATCCATGAA
CGCTGGGGCAAGCTTGATATTCTGGTGGCCAATGCCGGCATATTGGGCACGATTTCGCCCATTGGCCATGTCGAGGCCAA
AACCTTCGAGAAGGTCATGAATATCAATGTCACCAGCGTCTGGCGCCTGATCCGTTCGGTCGATCCGCTGCTGCGCGCCT
CGGATGCCGGGCGGGCGATCATGCTCTCCTCCGGTGTGGCGCATAGCTGCCGCGCCTTCTGGGGGCCTTATGCCGCCTCC
AAGGCCGCCGTCGAGGTTATGGCGCGGTGCTGGGCCGAAGAAACCAAGAAGATGAAGCTCAAGATCAATTCGGTCAATCC
GGGCGCAACCCGCACCGCCATGCGCGCGCAGGCCATGCCGGGCGAAGACCCGGAAACGCTCCCCACGCCGCAATCGGTCG
CCGAAAAGATCGTCAAGCTTGCCGATCCGAAACTTGAAGTGACGGGCAAGCTTTTCGACGTGCGCCAGGACCGCTTCCTC
GACTATCACATGCCAAGCTGA

Upstream 100 bases:

>100_bases
ACACCTTGTCGCTGCTCGCCAGCAACGGCTGATCGCCCTTAACTACGCAGGCGGCTTTCAGGCCGCCTGTTTCATGTTTC
TGAACGCATACGGGGACGCA

Downstream 100 bases:

>100_bases
TTTGTTTCTTCCGGCCTTGCATAAAGCATGTCTCCCATAAGTGGGAACCGGTTCAGGAGCGCATCGATCTCAGGCATTCT
GCCGTCAATTGTCACCGGAC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MNIDLTGRLALVTGASRGIGYFLSLELAKRGAHVIAVARTVGGLEELDDEIRKLGSSATLVPLDITDMEALDRLGGTIHE
RWGKLDILVANAGILGTISPIGHVEAKTFEKVMNINVTSVWRLIRSVDPLLRASDAGRAIMLSSGVAHSCRAFWGPYAAS
KAAVEVMARCWAEETKKMKLKINSVNPGATRTAMRAQAMPGEDPETLPTPQSVAEKIVKLADPKLEVTGKLFDVRQDRFL
DYHMPS

Sequences:

>Translated_246_residues
MNIDLTGRLALVTGASRGIGYFLSLELAKRGAHVIAVARTVGGLEELDDEIRKLGSSATLVPLDITDMEALDRLGGTIHE
RWGKLDILVANAGILGTISPIGHVEAKTFEKVMNINVTSVWRLIRSVDPLLRASDAGRAIMLSSGVAHSCRAFWGPYAAS
KAAVEVMARCWAEETKKMKLKINSVNPGATRTAMRAQAMPGEDPETLPTPQSVAEKIVKLADPKLEVTGKLFDVRQDRFL
DYHMPS
>Mature_246_residues
MNIDLTGRLALVTGASRGIGYFLSLELAKRGAHVIAVARTVGGLEELDDEIRKLGSSATLVPLDITDMEALDRLGGTIHE
RWGKLDILVANAGILGTISPIGHVEAKTFEKVMNINVTSVWRLIRSVDPLLRASDAGRAIMLSSGVAHSCRAFWGPYAAS
KAAVEVMARCWAEETKKMKLKINSVNPGATRTAMRAQAMPGEDPETLPTPQSVAEKIVKLADPKLEVTGKLFDVRQDRFL
DYHMPS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4557649, Length=192, Percent_Identity=32.8125, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI7657478, Length=212, Percent_Identity=29.7169811320755, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI32483357, Length=204, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7705925, Length=195, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=188, Percent_Identity=27.1276595744681, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4504505, Length=239, Percent_Identity=26.3598326359833, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=27.1276595744681, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503817, Length=228, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=26.4550264550265, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI19743808, Length=195, Percent_Identity=31.7948717948718, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI20149619, Length=256, Percent_Identity=26.953125, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7705855, Length=230, Percent_Identity=24.7826086956522, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI32455239, Length=211, Percent_Identity=29.3838862559242, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI5031765, Length=211, Percent_Identity=29.3838862559242, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787526, Length=238, Percent_Identity=37.3949579831933, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082100, Length=231, Percent_Identity=34.1991341991342, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=29.1497975708502, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790717, Length=192, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789378, Length=197, Percent_Identity=31.4720812182741, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=193, Percent_Identity=26.4248704663212, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787820, Length=218, Percent_Identity=24.7706422018349, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786812, Length=203, Percent_Identity=25.1231527093596, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786701, Length=192, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1789208, Length=194, Percent_Identity=25.7731958762887, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=248, Percent_Identity=32.6612903225806, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=245, Percent_Identity=31.0204081632653, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=245, Percent_Identity=28.9795918367347, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=247, Percent_Identity=31.1740890688259, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=247, Percent_Identity=31.9838056680162, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=245, Percent_Identity=30.6122448979592, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=247, Percent_Identity=28.7449392712551, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=244, Percent_Identity=29.5081967213115, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=243, Percent_Identity=29.2181069958848, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=242, Percent_Identity=30.9917355371901, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=249, Percent_Identity=32.5301204819277, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=248, Percent_Identity=29.4354838709677, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=219, Percent_Identity=25.5707762557078, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=198, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=209, Percent_Identity=28.7081339712919, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=231, Percent_Identity=31.6017316017316, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=241, Percent_Identity=25.7261410788382, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=198, Percent_Identity=32.3232323232323, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=244, Percent_Identity=27.4590163934426, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=248, Percent_Identity=28.6290322580645, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=260, Percent_Identity=27.3076923076923, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=224, Percent_Identity=28.125, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507613, Length=197, Percent_Identity=27.9187817258883, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=197, Percent_Identity=27.9187817258883, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=155, Percent_Identity=27.741935483871, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=197, Percent_Identity=32.48730964467, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193210355, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=209, Percent_Identity=29.6650717703349, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=244, Percent_Identity=24.1803278688525, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17557780, Length=199, Percent_Identity=25.1256281407035, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=25.4826254826255, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=192, Percent_Identity=25, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=232, Percent_Identity=31.8965517241379, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322226, Length=210, Percent_Identity=30.4761904761905, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322861, Length=253, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=29.0155440414508, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644339, Length=207, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=35.0785340314136, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571526, Length=205, Percent_Identity=34.6341463414634, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355319, Length=188, Percent_Identity=27.1276595744681, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=33.8624338624339, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24643142, Length=202, Percent_Identity=35.1485148514851, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356301, Length=245, Percent_Identity=26.9387755102041, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116007236, Length=200, Percent_Identity=26, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21358495, Length=229, Percent_Identity=24.8908296943231, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737361, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357673, Length=218, Percent_Identity=26.605504587156, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648944, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI116007238, Length=186, Percent_Identity=25.2688172043011, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=26.7206477732794, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26673; Mature: 26673

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDLTGRLALVTGASRGIGYFLSLELAKRGAHVIAVARTVGGLEELDDEIRKLGSSATL
CCCCCCCEEEEEECCCCCCEEEEEEEHHHCCCEEEEEHHHHCCHHHHHHHHHHCCCCCEE
VPLDITDMEALDRLGGTIHERWGKLDILVANAGILGTISPIGHVEAKTFEKVMNINVTSV
EEECCCCHHHHHHHCCHHHHHCCCEEEEEECCCCEECCCCCCCCHHHHHHHHHCCCHHHH
WRLIRSVDPLLRASDAGRAIMLSSGVAHSCRAFWGPYAASKAAVEVMARCWAEETKKMKL
HHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEE
KINSVNPGATRTAMRAQAMPGEDPETLPTPQSVAEKIVKLADPKLEVTGKLFDVRQDRFL
EEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHEE
DYHMPS
ECCCCC
>Mature Secondary Structure
MNIDLTGRLALVTGASRGIGYFLSLELAKRGAHVIAVARTVGGLEELDDEIRKLGSSATL
CCCCCCCEEEEEECCCCCCEEEEEEEHHHCCCEEEEEHHHHCCHHHHHHHHHHCCCCCEE
VPLDITDMEALDRLGGTIHERWGKLDILVANAGILGTISPIGHVEAKTFEKVMNINVTSV
EEECCCCHHHHHHHCCHHHHHCCCEEEEEECCCCEECCCCCCCCHHHHHHHHHCCCHHHH
WRLIRSVDPLLRASDAGRAIMLSSGVAHSCRAFWGPYAASKAAVEVMARCWAEETKKMKL
HHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEE
KINSVNPGATRTAMRAQAMPGEDPETLPTPQSVAEKIVKLADPKLEVTGKLFDVRQDRFL
EEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHEE
DYHMPS
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]