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The map label for this gene is nhaA [H]

Identifier: 225851933

GI number: 225851933

Start: 420881

End: 423172

Strand: Reverse

Name: nhaA [H]

Synonym: BMEA_A0428

Alternate gene names: 225851933

Gene position: 423172-420881 (Counterclockwise)

Preceding gene: 225851934

Following gene: 225851932

Centisome position: 19.91

GC content: 58.77

Gene sequence:

>2292_bases
TTGTTCTGCCTTTCCGGCCCGTTTTTATTCCAACTGTGCCGAAGGTCATCCTTAGACGATAAAAACAATAAACGGAAACC
GATGAATCATAGCCCGCAATCCGCTCGCCCCGTTTCCATCATGCGACGTTTTCTGGACAGCGAGGCCGCTGGCGGCATAA
CGCTCATGGCTGCAGCGGCGCTTGCCCTCATCGTTGCAAATTCGCCCTTTGCCCAGACCTATTTCGATGCGTTGCATCTA
TATATCGGCCCGCTCAGCCTTGCGCACTGGATCAACGATGCGCTGATGGCAATATTCTTTTTGCTGGTGGGACTGGAAAT
CAAGCGCGAGATGCTGGACGGGCAGCTCGCAAGCTGGCCCAACCGCATGTTGCCGGGCATTGCGGCAGCGGGCGGCGTCA
TTTTGCCTGCAATCATTTTCGCGGTTCTCAACCATGACAATCCGGCCAAGCTGCGCGGCTGGGCGGTGCCATCGGCAACC
GATATCGCCTTTGCGCTCGGCGTACTGTCGCTTCTGGGTTCGCGCGCGCCGTCAAGCCTCAAGGTGTTTCTGGCAACGCT
TGCCATTCTTGACGACCTTGCCGCCGTGGTCATCATCGCAATCTTCTACACGGCTGAAATTTCCATGCCCTATCTGGGCG
CGGCCTTTATCACCGCCGCGGTCCTCTTTGTCATGAACCGCATGGACGTGGTGAAGCTCCTGCCTTATCTGATCAGCGCT
GTGATCCTCTGGTTCTTCGTCTTCAATTCCGGCGTTCATGCCACGGTTGCCGGTGTTGTCGCAGCCCTCATGATCCCGCT
AAAACCTGCACCCGGCAGACCCGACGACATGACCTCGCCCCTGCACAAGCTGGAACATGCACTGGCCAAGCCCGTTGCCT
TCATCGTCGTGCCGATCTTCGGCTTTGCCAATGCGGGCATTTCCTTCAAGGGGCTTGAGGCTTCCGTCCTGGGCGACACG
CTGACACTCGGCATCCTGCTCGGCCTTTTCCTCGGCAAGCAGTTCGGCGTCTTCAGCGCGGCCTGGCTCGCCATCAAAAC
GGGGCTTGCCGAAAAGCCGATGGGCGCAAGCTGGGTTCAGCTTTACGGCGTCGCCATTCTTTGCGGCATCGGCTTTACGA
TGAGCATCTTCATCGGCCTTCTCTCCTTCCCGTCCGACCTCATGCAGACGGAAACGAAGATCGGTGTCCTTTCCGGCTCC
GCCCTTTCGGCCATTTGCGGCTATCTCCTGTTGCGGGCGGCGCGGCCAGACCAAAGCGCGGCTAACCCGCTCTGGAAAGC
TGATGAGTCGCCCGAAGCGAAAAATTTCGGGCGATTTCTTTGTGTTTTCCACTTTGCTTCCTACATTGCATCCACATATT
GCACGGAGCGGTTGCAAGCCGCTTCATCCCTTTTGCGCCGTTCAAGTTTGGAGTTCGCCTTGCCCGGTCTGTTGAAACGC
CTTATTCCCCGCCGTTTTCGCGCCGTGGAAACGGAAATCCCCGTCGTGCGCCTGCATGGCGCAATCATGACCGGCGGCAC
ATCCTTGCGGCCCACGCTTTCGCTCGCATCGACGGCCGGTATTCTGGAAAAGGCCTTTGCCGACAAGCATGCCCCTGCGG
TTGCCATATCCATCAATTCGCCGGGCGGCGTGCCGGTGCAATCGCGCCTGATCTATCGCCGCATCCGCGATCTTGCCGTG
GAACATCAAAAGAAGGTTTTCGTCTTCGTGGAAGATGTGGCGGCCTCCGGCGGCTACATGATCGCGCTTGCGGGCGACGA
AATCATCGCCGACCCCTCCTCCATCGTTGGCTCCATCGGCGTCGTTTCGGCCTCTTTCGGCTTTCCCGAATTGCTGAAGA
AGATCGGTGTGGAGCGGCGTGTCTATACGGCGGGCAGCAACAAGGTGACACTCGATCCGTTCCAGCCGGAAAAGGCCGAG
GACATCGAACGGCTGAAAGCACTTCAGCTTGAAATCCACGCCACCTTCATCGACATGGTGAAGGAGCGGCGCGCCGGCAA
GCTTGGCGACAATCCCGATCTTTTCAGCGGCCTGTTCTGGACCGGCACCACCGCCGCCTCGCTCGGCCTCATCGACGGGC
TTGGCGACATGCTCAGTTTTCTGCGCAAGACCTATGGCGACAAGGTGAAACTGAAGCTCATCCAGCCGCAACGCGGCCTT
CTGGGCCGCAAGCTGTCCGGCATCGGCATGGATTCAGGCAGTGTCGAGCCAGCGCAAATCGCCGCCCATCTTGGCGACGG
GCTGCTTTGTGTCGCGGAAGAAAAAGCAATCTGGGCACGCTATGGGCTTTGA

Upstream 100 bases:

>100_bases
GCCTGCGGAAAACTGGCAGGCTTTGCCCGATTTTCCCTCGGCACGGTTCGATTTTTATTGAAACGGCATATGCGACCCAA
TATCTCTGGGACTGAAATTT

Downstream 100 bases:

>100_bases
ACTCCATGGATTTACCATGATATGCTGCCACAAATGAGAGGATGGAGGGGCGCTCCTGGTGGATTGAATTTGACGCTTGC
TCGGCCCCCCTATCCGAGGG

Product: Na+/H+ antiporter NhaA

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MFCLSGPFLFQLCRRSSLDDKNNKRKPMNHSPQSARPVSIMRRFLDSEAAGGITLMAAAALALIVANSPFAQTYFDALHL
YIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWPNRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSAT
DIAFALGVLSLLGSRAPSSLKVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMDVVKLLPYLISA
VILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIFGFANAGISFKGLEASVLGDT
LTLGILLGLFLGKQFGVFSAAWLAIKTGLAEKPMGASWVQLYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGS
ALSAICGYLLLRAARPDQSAANPLWKADESPEAKNFGRFLCVFHFASYIASTYCTERLQAASSLLRRSSLEFALPGLLKR
LIPRRFRAVETEIPVVRLHGAIMTGGTSLRPTLSLASTAGILEKAFADKHAPAVAISINSPGGVPVQSRLIYRRIRDLAV
EHQKKVFVFVEDVAASGGYMIALAGDEIIADPSSIVGSIGVVSASFGFPELLKKIGVERRVYTAGSNKVTLDPFQPEKAE
DIERLKALQLEIHATFIDMVKERRAGKLGDNPDLFSGLFWTGTTAASLGLIDGLGDMLSFLRKTYGDKVKLKLIQPQRGL
LGRKLSGIGMDSGSVEPAQIAAHLGDGLLCVAEEKAIWARYGL

Sequences:

>Translated_763_residues
MFCLSGPFLFQLCRRSSLDDKNNKRKPMNHSPQSARPVSIMRRFLDSEAAGGITLMAAAALALIVANSPFAQTYFDALHL
YIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWPNRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSAT
DIAFALGVLSLLGSRAPSSLKVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMDVVKLLPYLISA
VILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIFGFANAGISFKGLEASVLGDT
LTLGILLGLFLGKQFGVFSAAWLAIKTGLAEKPMGASWVQLYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGS
ALSAICGYLLLRAARPDQSAANPLWKADESPEAKNFGRFLCVFHFASYIASTYCTERLQAASSLLRRSSLEFALPGLLKR
LIPRRFRAVETEIPVVRLHGAIMTGGTSLRPTLSLASTAGILEKAFADKHAPAVAISINSPGGVPVQSRLIYRRIRDLAV
EHQKKVFVFVEDVAASGGYMIALAGDEIIADPSSIVGSIGVVSASFGFPELLKKIGVERRVYTAGSNKVTLDPFQPEKAE
DIERLKALQLEIHATFIDMVKERRAGKLGDNPDLFSGLFWTGTTAASLGLIDGLGDMLSFLRKTYGDKVKLKLIQPQRGL
LGRKLSGIGMDSGSVEPAQIAAHLGDGLLCVAEEKAIWARYGL
>Mature_763_residues
MFCLSGPFLFQLCRRSSLDDKNNKRKPMNHSPQSARPVSIMRRFLDSEAAGGITLMAAAALALIVANSPFAQTYFDALHL
YIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWPNRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSAT
DIAFALGVLSLLGSRAPSSLKVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMDVVKLLPYLISA
VILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIFGFANAGISFKGLEASVLGDT
LTLGILLGLFLGKQFGVFSAAWLAIKTGLAEKPMGASWVQLYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGS
ALSAICGYLLLRAARPDQSAANPLWKADESPEAKNFGRFLCVFHFASYIASTYCTERLQAASSLLRRSSLEFALPGLLKR
LIPRRFRAVETEIPVVRLHGAIMTGGTSLRPTLSLASTAGILEKAFADKHAPAVAISINSPGGVPVQSRLIYRRIRDLAV
EHQKKVFVFVEDVAASGGYMIALAGDEIIADPSSIVGSIGVVSASFGFPELLKKIGVERRVYTAGSNKVTLDPFQPEKAE
DIERLKALQLEIHATFIDMVKERRAGKLGDNPDLFSGLFWTGTTAASLGLIDGLGDMLSFLRKTYGDKVKLKLIQPQRGL
LGRKLSGIGMDSGSVEPAQIAAHLGDGLLCVAEEKAIWARYGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=389, Percent_Identity=47.8149100257069, Blast_Score=296, Evalue=4e-81,
Organism=Escherichia coli, GI1787527, Length=172, Percent_Identity=34.3023255813954, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788064, Length=207, Percent_Identity=31.8840579710145, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 81835; Mature: 81835

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCLSGPFLFQLCRRSSLDDKNNKRKPMNHSPQSARPVSIMRRFLDSEAAGGITLMAAAA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
LALIVANSPFAQTYFDALHLYIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
NRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSATDIAFALGVLSLLGSRAPSSL
HHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
KVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMDVVKLLPYLISA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIF
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
GFANAGISFKGLEASVLGDTLTLGILLGLFLGKQFGVFSAAWLAIKTGLAEKPMGASWVQ
HHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
LYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGSALSAICGYLLLRAARPDQSA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCC
ANPLWKADESPEAKNFGRFLCVFHFASYIASTYCTERLQAASSLLRRSSLEFALPGLLKR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIPRRFRAVETEIPVVRLHGAIMTGGTSLRPTLSLASTAGILEKAFADKHAPAVAISINS
HHHHHHHHHHCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PGGVPVQSRLIYRRIRDLAVEHQKKVFVFVEDVAASGGYMIALAGDEIIADPSSIVGSIG
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCHHCCCHHHHHHHH
VVSASFGFPELLKKIGVERRVYTAGSNKVTLDPFQPEKAEDIERLKALQLEIHATFIDMV
HHCCCCCCHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KERRAGKLGDNPDLFSGLFWTGTTAASLGLIDGLGDMLSFLRKTYGDKVKLKLIQPQRGL
HHHHCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCH
LGRKLSGIGMDSGSVEPAQIAAHLGDGLLCVAEEKAIWARYGL
HHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHCCC
>Mature Secondary Structure
MFCLSGPFLFQLCRRSSLDDKNNKRKPMNHSPQSARPVSIMRRFLDSEAAGGITLMAAAA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
LALIVANSPFAQTYFDALHLYIGPLSLAHWINDALMAIFFLLVGLEIKREMLDGQLASWP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
NRMLPGIAAAGGVILPAIIFAVLNHDNPAKLRGWAVPSATDIAFALGVLSLLGSRAPSSL
HHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
KVFLATLAILDDLAAVVIIAIFYTAEISMPYLGAAFITAAVLFVMNRMDVVKLLPYLISA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILWFFVFNSGVHATVAGVVAALMIPLKPAPGRPDDMTSPLHKLEHALAKPVAFIVVPIF
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
GFANAGISFKGLEASVLGDTLTLGILLGLFLGKQFGVFSAAWLAIKTGLAEKPMGASWVQ
HHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
LYGVAILCGIGFTMSIFIGLLSFPSDLMQTETKIGVLSGSALSAICGYLLLRAARPDQSA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCC
ANPLWKADESPEAKNFGRFLCVFHFASYIASTYCTERLQAASSLLRRSSLEFALPGLLKR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIPRRFRAVETEIPVVRLHGAIMTGGTSLRPTLSLASTAGILEKAFADKHAPAVAISINS
HHHHHHHHHHCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PGGVPVQSRLIYRRIRDLAVEHQKKVFVFVEDVAASGGYMIALAGDEIIADPSSIVGSIG
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCHHCCCHHHHHHHH
VVSASFGFPELLKKIGVERRVYTAGSNKVTLDPFQPEKAEDIERLKALQLEIHATFIDMV
HHCCCCCCHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KERRAGKLGDNPDLFSGLFWTGTTAASLGLIDGLGDMLSFLRKTYGDKVKLKLIQPQRGL
HHHHCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCH
LGRKLSGIGMDSGSVEPAQIAAHLGDGLLCVAEEKAIWARYGL
HHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA