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The map label for this gene is gmd [H]

Identifier: 225686228

GI number: 225686228

Start: 384859

End: 385929

Strand: Reverse

Name: gmd [H]

Synonym: BMEA_B0397

Alternate gene names: 225686228

Gene position: 385929-384859 (Counterclockwise)

Preceding gene: 225686232

Following gene: 225686224

Centisome position: 32.55

GC content: 56.3

Gene sequence:

>1071_bases
TTGCAGGATAAAACAGCTCTCATCGTCGGTGTAACCGGGCAGGATGGCGCCTATCTAAGCGAGCTTCTGCTGGGCAAGGG
CTATCGGGTGCATGGCCTGAAAAGGCGGTCATCGTCATTCAATACGGCGCGTATCGACCATCTTTATCAAGACCCGCATG
AGGAAGACATCCGCTTTCGCCTGCATTTCGGCGACCTGACAGACGCAACCAATCTGTGCCGCGTCATCCAGGAAGTGCAG
CCTGACGAGATTTATAATCTCGGCGCCCAGAGCCATGTGCAGGTGAGTTTTGAAACGCCGGAATATACGGCCAATGCCGA
TGCGCTCGGCACACTGCGCCTGCTTGAATCCATGCGCATCCTGGGTCTCGGCAAAAGCTGCCGTTTCTATCAGGCTTCCA
CTTCGGAGCTTTTCGGCAATAGTTCCCACCATGCGCAAAACGAGCAGACGCCTTTCGCTCCGCGCAGCCCATATGCAACC
GCCAAGCTTTATGCTTACTGGACAACGGTGAACTATCGCGATGCCTATGGTTTCCACGCCTCGAACGGCATCTTGTTCAA
TCATGAAAGCCCCTTGCGGGGCGAAACCTTCGTCACCCGCAAGATCACGCGCGCAGTTGCAGCCATCGAACGCGGGCTAC
AGGACAGGCTGCGGCTTGGCAATCTTGAGGCCCGCCGCGACTGGGGCCATGCGCGCGATTATGTCGAAGGCATGTGGCGC
ATTCTACAGGAAGACACACCGGACGATTATGTGCTCGCCACGGGTGAAACGCATACGGTGCGTGAATTCATCGAACACGC
CTTCAAGGCCGTTGACAAGCAGATCGTATGGCATGGCGATGGCGTGGACGAGCTCGGCATCGACCGCAAGACGGGCAATT
GCCTGATCGAGATCGACCCGCGCTATTTCCGCCCCAACGAAGTGGATTTCCTTATGGGCGATGCTTCCAAGGCAAAAGAC
CGTCTGGGCTGGCAACATACGACCGGCTTTGAAAATCTCGTGGCTGAAATGGTGGATTGGGATCTGCGCAACATCATGCG
GGAGGTAGGACGCAATGATTTCTACGGCTGA

Upstream 100 bases:

>100_bases
TGGGAGCGCCGGGGCTGGAATTGCCGTTTTGGAGCCGTTCTGCCTTTTCGGGAAATCGCTACGATAGTGTCATCGAAAAC
TGAGGCCGGAGGGCAAGACC

Downstream 100 bases:

>100_bases
GACCGGGCGCGAACCCGTCTATTCACTCACGGGAAAGAAAATCTTCGTCGCCGGTCACACCGGCATGGTCGGCTCAGCCA
TTTTGCGGCGCCTCCAGCAT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MQDKTALIVGVTGQDGAYLSELLLGKGYRVHGLKRRSSSFNTARIDHLYQDPHEEDIRFRLHFGDLTDATNLCRVIQEVQ
PDEIYNLGAQSHVQVSFETPEYTANADALGTLRLLESMRILGLGKSCRFYQASTSELFGNSSHHAQNEQTPFAPRSPYAT
AKLYAYWTTVNYRDAYGFHASNGILFNHESPLRGETFVTRKITRAVAAIERGLQDRLRLGNLEARRDWGHARDYVEGMWR
ILQEDTPDDYVLATGETHTVREFIEHAFKAVDKQIVWHGDGVDELGIDRKTGNCLIEIDPRYFRPNEVDFLMGDASKAKD
RLGWQHTTGFENLVAEMVDWDLRNIMREVGRNDFYG

Sequences:

>Translated_356_residues
MQDKTALIVGVTGQDGAYLSELLLGKGYRVHGLKRRSSSFNTARIDHLYQDPHEEDIRFRLHFGDLTDATNLCRVIQEVQ
PDEIYNLGAQSHVQVSFETPEYTANADALGTLRLLESMRILGLGKSCRFYQASTSELFGNSSHHAQNEQTPFAPRSPYAT
AKLYAYWTTVNYRDAYGFHASNGILFNHESPLRGETFVTRKITRAVAAIERGLQDRLRLGNLEARRDWGHARDYVEGMWR
ILQEDTPDDYVLATGETHTVREFIEHAFKAVDKQIVWHGDGVDELGIDRKTGNCLIEIDPRYFRPNEVDFLMGDASKAKD
RLGWQHTTGFENLVAEMVDWDLRNIMREVGRNDFYG
>Mature_356_residues
MQDKTALIVGVTGQDGAYLSELLLGKGYRVHGLKRRSSSFNTARIDHLYQDPHEEDIRFRLHFGDLTDATNLCRVIQEVQ
PDEIYNLGAQSHVQVSFETPEYTANADALGTLRLLESMRILGLGKSCRFYQASTSELFGNSSHHAQNEQTPFAPRSPYAT
AKLYAYWTTVNYRDAYGFHASNGILFNHESPLRGETFVTRKITRAVAAIERGLQDRLRLGNLEARRDWGHARDYVEGMWR
ILQEDTPDDYVLATGETHTVREFIEHAFKAVDKQIVWHGDGVDELGIDRKTGNCLIEIDPRYFRPNEVDFLMGDASKAKD
RLGWQHTTGFENLVAEMVDWDLRNIMREVGRNDFYG

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=57.5581395348837, Blast_Score=421, Evalue=1e-118,
Organism=Escherichia coli, GI1788366, Length=350, Percent_Identity=59.4285714285714, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI48994969, Length=306, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788353, Length=304, Percent_Identity=25.3289473684211, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=58.0645161290323, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=58.0645161290323, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=58.0645161290323, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=58.0645161290323, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=58.0645161290323, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=58.0645161290323, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24158427, Length=348, Percent_Identity=58.0459770114943, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 40682; Mature: 40682

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKTALIVGVTGQDGAYLSELLLGKGYRVHGLKRRSSSFNTARIDHLYQDPHEEDIRFR
CCCCEEEEEEECCCCCHHHHHHHHCCCCEEECCHHCCCCCCHHHHHHHHCCCCCCCEEEE
LHFGDLTDATNLCRVIQEVQPDEIYNLGAQSHVQVSFETPEYTANADALGTLRLLESMRI
EEECCCCCHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LGLGKSCRFYQASTSELFGNSSHHAQNEQTPFAPRSPYATAKLYAYWTTVNYRDAYGFHA
HCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEC
SNGILFNHESPLRGETFVTRKITRAVAAIERGLQDRLRLGNLEARRDWGHARDYVEGMWR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
ILQEDTPDDYVLATGETHTVREFIEHAFKAVDKQIVWHGDGVDELGIDRKTGNCLIEIDP
HHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHCCCCCCCCEEEEECC
RYFRPNEVDFLMGDASKAKDRLGWQHTTGFENLVAEMVDWDLRNIMREVGRNDFYG
CCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQDKTALIVGVTGQDGAYLSELLLGKGYRVHGLKRRSSSFNTARIDHLYQDPHEEDIRFR
CCCCEEEEEEECCCCCHHHHHHHHCCCCEEECCHHCCCCCCHHHHHHHHCCCCCCCEEEE
LHFGDLTDATNLCRVIQEVQPDEIYNLGAQSHVQVSFETPEYTANADALGTLRLLESMRI
EEECCCCCHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LGLGKSCRFYQASTSELFGNSSHHAQNEQTPFAPRSPYATAKLYAYWTTVNYRDAYGFHA
HCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEC
SNGILFNHESPLRGETFVTRKITRAVAAIERGLQDRLRLGNLEARRDWGHARDYVEGMWR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
ILQEDTPDDYVLATGETHTVREFIEHAFKAVDKQIVWHGDGVDELGIDRKTGNCLIEIDP
HHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHCCCCCCCCEEEEECC
RYFRPNEVDFLMGDASKAKDRLGWQHTTGFENLVAEMVDWDLRNIMREVGRNDFYG
CCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10065558 [H]