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The map label for this gene is clcA [H]

Identifier: 225686185

GI number: 225686185

Start: 330243

End: 331598

Strand: Reverse

Name: clcA [H]

Synonym: BMEA_B0349

Alternate gene names: 225686185

Gene position: 331598-330243 (Counterclockwise)

Preceding gene: 225686186

Following gene: 225686184

Centisome position: 27.97

GC content: 60.18

Gene sequence:

>1356_bases
GTGCGCAAGTCATATAAACGCGTTCCGGTTATTCGCCGCTCACATGCCATGTGGATGTCGCCCCGTGTGTGGAAACCACG
GCTCGTCTTCTGGTGTGGCGCGCTTGCCATCGGCATTATCAGTGTCGGCTTTGCCGAGGCCGCCGACATAGCACAGGACT
GGTTCCACTCACTGACAAGTGGCAGCCCCTTGCGCGCATGGCTTCCCCTTCTCATCACGCCGCTCGGCTTTATGTTCTGC
TCGTGGGTCGCCCTGGTCTGGTTTCCCAATTCAGGCGGCAGCGGCATTCCACAGGCCATCGCGGCACGGCATTTGAACGA
TCATGAAGATCGCTCTCTTTTGCTCTCCATCCGCGTCGCCACCGGCAAGATCGTGCTCACCATCATCGGCCTTTTCTGCG
GCGCCTCCATCGGGCGCGAAGGCCCGACGGTGCAGATCGGCGCTTCGATCATGCTACAGGCAGCGCGTTTCGGCGGGATG
GAAAAAGCGCGCGGCCTCATTCTGGCAGGCTCGGCTGCGGGCATCGCGGCAGCATTCAACACCCCGCTTGCCGGTATCGT
CTTCGCCATTGAGGAAATGGGGCGCGCCTATGCCGCGCGCACCAATGGCCTCGTACTTTCGGCCGTCATTCTGGCTGGCC
TCGCTTCCCTCGGCCTTGTCGGAAATTACAATTATTTCGGCTTCACGACAGTCACGGCGTCCACCGGCAAGGATTGGATC
CTGACCATAGCCTGCGGCATTTTTGGCGGGGCATTCGGTGCAGCATTCAGCGCGCTGGCGCTCAATATGGGGCGGCGCGT
GCGGCGGCGTGTCCAAAAAGCGCCTCTGCGCAACATGGTGATTTTTGCCGGAATTTGCGGCCTGCTTGTTGCGCTGATCG
GTATTGCCTCCGGCGGCATGACTTTCGGCGCAGGCTATGATCAGGCACGCAGCGCCGTTGAAGGCGCCACCCTGCCGCCA
TTCTATTTCGTGGAAAAATTCACGGTGGGTTTGCTCTCCATGATTTCGGGTATTCCCGGCGGCATTTTCGCGCCGTCGCT
TTCCGTTGGCGCGGGCCTTGGCAGCACGATAGGCCTGCTGCTGGGAACAAGCGCCAGCCTTGCCGCGGTTCTGGGCATGG
CAGGCTATTTTGCCGGTGCCGTGCAGGCGCCGATGACGGCCTTTGTCATCATTCTGGAAATGACCGGCAATCATAGCAAT
GTCATTCCGCTGATGTGCGCTTCCATGCTCGGCTATGGCACGGCGCGGCTCATCTCGCACGAGCCGCTTTATCATGCGCT
ATCGCGTATTTTTGTTGCGGACATATTGCGCCAGCGCCGCGCACGGGAGAAAACAATACAGCCGGAATTGACGTGA

Upstream 100 bases:

>100_bases
GGTAACACGGTTATATCCAAATGGAAAGCCTTTTGGATATAAGATTCAGTTGCGAATAACGATTTGCATGGTAAAGCACA
CACAGCCAAAAGAGGGCCAA

Downstream 100 bases:

>100_bases
GTTTGATCGGGGGAGGATCGTTCATGGACCGCAGAACATTTGCCAAGTCGCTTGCGGGGCTGGGAGCCATGCCCTTCGCC
GTCAATACCGCATCGGCCGG

Product: chloride channel core protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRKSYKRVPVIRRSHAMWMSPRVWKPRLVFWCGALAIGIISVGFAEAADIAQDWFHSLTSGSPLRAWLPLLITPLGFMFC
SWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVATGKIVLTIIGLFCGASIGREGPTVQIGASIMLQAARFGGM
EKARGLILAGSAAGIAAAFNTPLAGIVFAIEEMGRAYAARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWI
LTIACGIFGGAFGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGMTFGAGYDQARSAVEGATLPP
FYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLLLGTSASLAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSN
VIPLMCASMLGYGTARLISHEPLYHALSRIFVADILRQRRAREKTIQPELT

Sequences:

>Translated_451_residues
MRKSYKRVPVIRRSHAMWMSPRVWKPRLVFWCGALAIGIISVGFAEAADIAQDWFHSLTSGSPLRAWLPLLITPLGFMFC
SWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVATGKIVLTIIGLFCGASIGREGPTVQIGASIMLQAARFGGM
EKARGLILAGSAAGIAAAFNTPLAGIVFAIEEMGRAYAARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWI
LTIACGIFGGAFGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGMTFGAGYDQARSAVEGATLPP
FYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLLLGTSASLAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSN
VIPLMCASMLGYGTARLISHEPLYHALSRIFVADILRQRRAREKTIQPELT
>Mature_451_residues
MRKSYKRVPVIRRSHAMWMSPRVWKPRLVFWCGALAIGIISVGFAEAADIAQDWFHSLTSGSPLRAWLPLLITPLGFMFC
SWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVATGKIVLTIIGLFCGASIGREGPTVQIGASIMLQAARFGGM
EKARGLILAGSAAGIAAAFNTPLAGIVFAIEEMGRAYAARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWI
LTIACGIFGGAFGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGMTFGAGYDQARSAVEGATLPP
FYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLLLGTSASLAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSN
VIPLMCASMLGYGTARLISHEPLYHALSRIFVADILRQRRAREKTIQPELT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=388, Percent_Identity=32.4742268041237, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081943, Length=306, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 47498; Mature: 47498

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSYKRVPVIRRSHAMWMSPRVWKPRLVFWCGALAIGIISVGFAEAADIAQDWFHSLTS
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSPLRAWLPLLITPLGFMFCSWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVA
CCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEC
TGKIVLTIIGLFCGASIGREGPTVQIGASIMLQAARFGGMEKARGLILAGSAAGIAAAFN
CCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHC
TPLAGIVFAIEEMGRAYAARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWI
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEE
LTIACGIFGGAFGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
TFGAGYDQARSAVEGATLPPFYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLL
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHHHH
LGTSASLAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSNVIPLMCASMLGYGTARLISH
HCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHCC
EPLYHALSRIFVADILRQRRAREKTIQPELT
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRKSYKRVPVIRRSHAMWMSPRVWKPRLVFWCGALAIGIISVGFAEAADIAQDWFHSLTS
CCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSPLRAWLPLLITPLGFMFCSWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVA
CCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEC
TGKIVLTIIGLFCGASIGREGPTVQIGASIMLQAARFGGMEKARGLILAGSAAGIAAAFN
CCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHC
TPLAGIVFAIEEMGRAYAARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWI
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEE
LTIACGIFGGAFGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
TFGAGYDQARSAVEGATLPPFYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLL
EECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHHHH
LGTSASLAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSNVIPLMCASMLGYGTARLISH
HCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHCC
EPLYHALSRIFVADILRQRRAREKTIQPELT
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA