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The map label for this gene is ybiC [C]

Identifier: 225686090

GI number: 225686090

Start: 226354

End: 227391

Strand: Reverse

Name: ybiC [C]

Synonym: BMEA_B0241

Alternate gene names: 225686090

Gene position: 227391-226354 (Counterclockwise)

Preceding gene: 225686091

Following gene: 225686086

Centisome position: 19.18

GC content: 63.39

Gene sequence:

>1038_bases
ATGACGGACGGCACCAACCTCACGATTGAAAAACTCCATGCGCGCGTGGAAGAGATTTTCCGCAAGGCGGGATTGAACGC
CATTCAGGCGGGCGCTGTTGCACGCGTGATCGTTGCGGGCGAGCGCGACCATTGCAAATCGCATGGCATTTACCGCATCG
AAGGCGCCTTGCGCACCGTGAAGGCTGGCAAGGTCAAGCCGGACGCCGTGCCGGAACTGGTGGCGCAGGAAGCTTCCGCC
ATCGTGCGGGTGGACGCAAAGGGCGGTTTTGCCAACCCGGCTTTCGAGCTTGGCGTGCCGGTTCTGGCGGAGCGTGCGCG
GAGCCATGGCCTTGCCGCCCTCGTCATCAATGATTGCACGCATTTTTCCGCGCTCTGGCCCGAAGTCGAGGCGCTGACGG
AAAAGGGCCTTGCCGGCCTGGTCATGTGCCCAAGCTATGCCACCGTTGCGCCAACCGGCGGCAGCAAGCCGCTGCTCGGC
ACCAATCCCTTCGCCTTCGGCTGGCCGCGCCGCGACAACCCGCCTTACGTATTCGATTTTGCAACCTCGGTTGCAGCACG
CGGCGAGATCGAACTGCATCGGCGTGCCGGAAAGCAGCTTCCCGAAGGCTGGGCCATCGATAAGGATGGCAAGCCGACCA
CCGACCCCGAAACGGCGCTTGAGGGCGCAATGCTGCCCTTCGGCGGGCACAAGGGATCGGCAATCAGCACCATGATCGAG
CTTCTGGCGGGAATCATGATCGGCGACCGCACCAGCCCGGAAGTGCTGGACTTCCTCGGCACGACAACGCTTTCGCCGGT
TCATGGTGAACTCATCATCGCCTTTTCGCCCGAAGCCTTTGCGGCTGGCCGCCCTGGCGATCCTTTCGCCCGCGCGGAAG
CCTTCTTCGAGGCGATTGTGGGGCAAGGCGCGCGCCTGCCCTCGCAACGTCGCTTTACCGCCCGCACCGCCTCGCAAAGC
GAAGGCATCACGCTCAACAAGGCGGAGATCGACTATCTCGACCAGCTTGCCGAAAAGGGCCTCGACGCTGTTTCGTGA

Upstream 100 bases:

>100_bases
CAGAAGAGGAGCGATGCGGGGCCGGAAGCGCGCATGATATCGATCATGCCAGCACTCCTTAAAAAGCGGCCCGCGTCGAA
ACAGTAATGAAAGATGGGAA

Downstream 100 bases:

>100_bases
TAAAATCCAAAGCAAAAGGCCCTCCGCAACGGGAGGGCCTTTTTACATAAGGCATTGCTTGATCACGCCTTGCAGCGCTG
TACGGCACCCGGCAGTTTGC

Product: malate/L-sulfolactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTDGTNLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKVKPDAVPELVAQEASA
IVRVDAKGGFANPAFELGVPVLAERARSHGLAALVINDCTHFSALWPEVEALTEKGLAGLVMCPSYATVAPTGGSKPLLG
TNPFAFGWPRRDNPPYVFDFATSVAARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEGAMLPFGGHKGSAISTMIE
LLAGIMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIVGQGARLPSQRRFTARTASQS
EGITLNKAEIDYLDQLAEKGLDAVS

Sequences:

>Translated_345_residues
MTDGTNLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKVKPDAVPELVAQEASA
IVRVDAKGGFANPAFELGVPVLAERARSHGLAALVINDCTHFSALWPEVEALTEKGLAGLVMCPSYATVAPTGGSKPLLG
TNPFAFGWPRRDNPPYVFDFATSVAARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEGAMLPFGGHKGSAISTMIE
LLAGIMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIVGQGARLPSQRRFTARTASQS
EGITLNKAEIDYLDQLAEKGLDAVS
>Mature_344_residues
TDGTNLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTVKAGKVKPDAVPELVAQEASAI
VRVDAKGGFANPAFELGVPVLAERARSHGLAALVINDCTHFSALWPEVEALTEKGLAGLVMCPSYATVAPTGGSKPLLGT
NPFAFGWPRRDNPPYVFDFATSVAARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEGAMLPFGGHKGSAISTMIEL
LAGIMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIVGQGARLPSQRRFTARTASQSE
GITLNKAEIDYLDQLAEKGLDAVS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=337, Percent_Identity=29.673590504451, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786727, Length=279, Percent_Identity=31.1827956989247, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790000, Length=332, Percent_Identity=24.3975903614458, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17536633, Length=340, Percent_Identity=28.5294117647059, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17507179, Length=354, Percent_Identity=25.4237288135593, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24667908, Length=273, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45553211, Length=273, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24667912, Length=273, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24667904, Length=273, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24658010, Length=281, Percent_Identity=24.5551601423488, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648360, Length=340, Percent_Identity=25.8823529411765, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 36602; Mature: 36471

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTNLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEEECCHHHHHCCCEEEECCHHHHH
KAGKVKPDAVPELVAQEASAIVRVDAKGGFANPAFELGVPVLAERARSHGLAALVINDCT
HCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHCCEEEEEEECCH
HFSALWPEVEALTEKGLAGLVMCPSYATVAPTGGSKPLLGTNPFAFGWPRRDNPPYVFDF
HHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ATSVAARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEGAMLPFGGHKGSAISTMIE
HHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHH
LLAGIMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIV
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHH
GQGARLPSQRRFTARTASQSEGITLNKAEIDYLDQLAEKGLDAVS
CCCCCCCCCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDGTNLTIEKLHARVEEIFRKAGLNAIQAGAVARVIVAGERDHCKSHGIYRIEGALRTV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEEECCHHHHHCCCEEEECCHHHHH
KAGKVKPDAVPELVAQEASAIVRVDAKGGFANPAFELGVPVLAERARSHGLAALVINDCT
HCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHCCEEEEEEECCH
HFSALWPEVEALTEKGLAGLVMCPSYATVAPTGGSKPLLGTNPFAFGWPRRDNPPYVFDF
HHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ATSVAARGEIELHRRAGKQLPEGWAIDKDGKPTTDPETALEGAMLPFGGHKGSAISTMIE
HHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHH
LLAGIMIGDRTSPEVLDFLGTTTLSPVHGELIIAFSPEAFAAGRPGDPFARAEAFFEAIV
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHH
GQGARLPSQRRFTARTASQSEGITLNKAEIDYLDQLAEKGLDAVS
CCCCCCCCCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]