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The map label for this gene is kefBC [H]

Identifier: 225686063

GI number: 225686063

Start: 195260

End: 197167

Strand: Reverse

Name: kefBC [H]

Synonym: BMEA_B0210

Alternate gene names: 225686063

Gene position: 197167-195260 (Counterclockwise)

Preceding gene: 225686070

Following gene: 225686059

Centisome position: 16.63

GC content: 59.49

Gene sequence:

>1908_bases
TTGCCGAAATCGGGGGTCTTCAAGGCAACCTCATCTACAATCTTCAAATACCAAGAGCACAGTATGGTCGCAAATGGCGG
GAGCCTTTACCTACAGAGCCTGATGATTCTGGGAGGTGCTATCATCGCCGCGCCCCTGTTCAAACGACTGGGGCTTGGCA
CCGTGCTTGGCTATCTTGCTGCGGGCATCACCATCGGCCCGGTCGCGCGCCTCATTGCGGATGGCGAGGAATTCCTGCAT
TTTTCCGAATTGGGTGTGGTTTTCCTGCTCTTCATCATCGGGCTTGAACTGAACCCTTCACGCCTGTGGTCGCTGCGCCA
TTCGATCTTCGGTCTGGGGACCGCACAGGTACTCCTGTGCGGCGCGGCGCTGGCCGCGCTTGGCGTCTATCTTGCCGGGC
TGGATACGGAAGCCGCCATTATCATCGGCTTCGGCCTTGCCCTTTCCTCGACCGCCTTTGCCATGCAGGTTCTGGAAGAC
CGTGCCGAAACCAACCAGAAGCACGGGCAGCGCGCCTTCGCCATCCTGCTGTTCCAGGACCTGGCCATCGTGCCCATTCT
GGCAATCATTCCCGCCCTTTCGCCGAATGAACCCTCGCAGGCAAGTGCTGGCTTTCATCTTGCCACGGCCATTGCCTCGA
TTGCCGCACTGGTTATTGCCGGGCGCTATCTCATCAATCCCATGTTCCGCATCATCGCCAATACGGGTGCGCGCGAAGTG
ATGATCGCAGCCGCCCTGTTCGTGGTGCTGGGATCGGCAAGCCTCCTGCAATATGCGGGCCTTTCCATGGCCATGGGCGC
ATTCATTGCAGGTGTGCTGCTCGCCGAATCCTCCTACCGGCATGAGCTGGAAGCCGACATCGAACCGTTCCGCGGAATTT
TCCTCGGCCTGTTCTTCGTTGCAGTCGGGCTTTCGCTCAACCTCTCCGTTATCCTGGAATATTGGGCCGTGATCCTTGCC
GCCGTCCCCATTTTCATGGCGACGAAGATTGTCATCATCTACCTTCTCTGCCGCATCTTCCGCTCCAGTCACAATGATGC
GGTGCGCATTGCCTTCCTGCTGCCGCAGGGCGGTGAATTCGCTTTCGTTCTTTTTTCCGCCGCCTCTGCTGCGGCAATCA
TCTCCTGCGCACTCGGTTCCGAACTGGTCGCAGCAGTCACCGTTTCCATGGCGCTGACGCCGCTTTCCGTCGCCATCGGT
TCAAGGCTTCTCATCAAGGACAAGGCCGACGATATAATCGAGGAAAATTTCGACGGCGCGGGCTCGGATGTCCTCATGAT
CGGCTTCTCGCGTTACGGGCAGATCGCGGCACAGATTCTCCTTGCCGGCGGCATTGATGTGACTGTGATCGACAGTTCCT
CCAACCGTGTCCGCGCGGCCGGCAAGTTCGGTTTCCGCATCTATTTTGGCGATGGCACCCGCAAGGATGTGCTAGAAGCG
GCAGGCATCCGCAAGGCCAAGATCGTTGCCATTTGCACGCACAAGAAATCGACGACCAACCACATCGTCAATCTGATCCA
GTCGGAATATCCCGACGTGCGCCTGTTCGTGCGCTCCTATGACCGCGAACATACGCTGCAACTGCGCGCGCAGGGTGTGG
AATACGAGCTGCGTGAAACCTTTGAATCCGGCCTTCTGTTCGGGCAGCGCACGCTGGAGGGGCTGGGCCTTTCCGAAGCC
AATGCCTATGCGATCCGCGAAGATGTGCGCCAGCGCGACGAAGACCGGCTGCATGTGCAGGCATCAGAGGGGATCATGGC
GGGGCGCCACCTGCTTTTCAACAAGCCAGTTACGCCCGAACCGCTGGTCAAGCCCACGCGCGAGGGCCAGCGCATCGACA
AATCGGACGATGGGCAGCGCGCGCCATCCCCGCAGGAAACGGCCGCCGCACCCGTTGCCGCGGAGTAA

Upstream 100 bases:

>100_bases
TGCAAGCCCTGATCCACGACTATCCCCAATCGGGACCTGCCAAAAAAAATCGTCAAATTGTTCGACATCGGGCTGATTGC
AGCCATATCTTGTTTCTATA

Downstream 100 bases:

>100_bases
CCCGCTTCCTTATCAAAGATCAGGCAATTTTTCCGGCAGGATCGGGGCGACCTTGCCATCGAGCGCCTGTTCGATCGCGC
GTTTCAACTCGTCCCGCACC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MPKSGVFKATSSTIFKYQEHSMVANGGSLYLQSLMILGGAIIAAPLFKRLGLGTVLGYLAAGITIGPVARLIADGEEFLH
FSELGVVFLLFIIGLELNPSRLWSLRHSIFGLGTAQVLLCGAALAALGVYLAGLDTEAAIIIGFGLALSSTAFAMQVLED
RAETNQKHGQRAFAILLFQDLAIVPILAIIPALSPNEPSQASAGFHLATAIASIAALVIAGRYLINPMFRIIANTGAREV
MIAAALFVVLGSASLLQYAGLSMAMGAFIAGVLLAESSYRHELEADIEPFRGIFLGLFFVAVGLSLNLSVILEYWAVILA
AVPIFMATKIVIIYLLCRIFRSSHNDAVRIAFLLPQGGEFAFVLFSAASAAAIISCALGSELVAAVTVSMALTPLSVAIG
SRLLIKDKADDIIEENFDGAGSDVLMIGFSRYGQIAAQILLAGGIDVTVIDSSSNRVRAAGKFGFRIYFGDGTRKDVLEA
AGIRKAKIVAICTHKKSTTNHIVNLIQSEYPDVRLFVRSYDREHTLQLRAQGVEYELRETFESGLLFGQRTLEGLGLSEA
NAYAIREDVRQRDEDRLHVQASEGIMAGRHLLFNKPVTPEPLVKPTREGQRIDKSDDGQRAPSPQETAAAPVAAE

Sequences:

>Translated_635_residues
MPKSGVFKATSSTIFKYQEHSMVANGGSLYLQSLMILGGAIIAAPLFKRLGLGTVLGYLAAGITIGPVARLIADGEEFLH
FSELGVVFLLFIIGLELNPSRLWSLRHSIFGLGTAQVLLCGAALAALGVYLAGLDTEAAIIIGFGLALSSTAFAMQVLED
RAETNQKHGQRAFAILLFQDLAIVPILAIIPALSPNEPSQASAGFHLATAIASIAALVIAGRYLINPMFRIIANTGAREV
MIAAALFVVLGSASLLQYAGLSMAMGAFIAGVLLAESSYRHELEADIEPFRGIFLGLFFVAVGLSLNLSVILEYWAVILA
AVPIFMATKIVIIYLLCRIFRSSHNDAVRIAFLLPQGGEFAFVLFSAASAAAIISCALGSELVAAVTVSMALTPLSVAIG
SRLLIKDKADDIIEENFDGAGSDVLMIGFSRYGQIAAQILLAGGIDVTVIDSSSNRVRAAGKFGFRIYFGDGTRKDVLEA
AGIRKAKIVAICTHKKSTTNHIVNLIQSEYPDVRLFVRSYDREHTLQLRAQGVEYELRETFESGLLFGQRTLEGLGLSEA
NAYAIREDVRQRDEDRLHVQASEGIMAGRHLLFNKPVTPEPLVKPTREGQRIDKSDDGQRAPSPQETAAAPVAAE
>Mature_634_residues
PKSGVFKATSSTIFKYQEHSMVANGGSLYLQSLMILGGAIIAAPLFKRLGLGTVLGYLAAGITIGPVARLIADGEEFLHF
SELGVVFLLFIIGLELNPSRLWSLRHSIFGLGTAQVLLCGAALAALGVYLAGLDTEAAIIIGFGLALSSTAFAMQVLEDR
AETNQKHGQRAFAILLFQDLAIVPILAIIPALSPNEPSQASAGFHLATAIASIAALVIAGRYLINPMFRIIANTGAREVM
IAAALFVVLGSASLLQYAGLSMAMGAFIAGVLLAESSYRHELEADIEPFRGIFLGLFFVAVGLSLNLSVILEYWAVILAA
VPIFMATKIVIIYLLCRIFRSSHNDAVRIAFLLPQGGEFAFVLFSAASAAAIISCALGSELVAAVTVSMALTPLSVAIGS
RLLIKDKADDIIEENFDGAGSDVLMIGFSRYGQIAAQILLAGGIDVTVIDSSSNRVRAAGKFGFRIYFGDGTRKDVLEAA
GIRKAKIVAICTHKKSTTNHIVNLIQSEYPDVRLFVRSYDREHTLQLRAQGVEYELRETFESGLLFGQRTLEGLGLSEAN
AYAIREDVRQRDEDRLHVQASEGIMAGRHLLFNKPVTPEPLVKPTREGQRIDKSDDGQRAPSPQETAAAPVAAE

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=360, Percent_Identity=26.3888888888889, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786232, Length=550, Percent_Identity=42.5454545454545, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1789749, Length=555, Percent_Identity=41.981981981982, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1786685, Length=515, Percent_Identity=28.7378640776699, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67982; Mature: 67851

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSGVFKATSSTIFKYQEHSMVANGGSLYLQSLMILGGAIIAAPLFKRLGLGTVLGYLA
CCCCCCEECCCHHHHEEHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGITIGPVARLIADGEEFLHFSELGVVFLLFIIGLELNPSRLWSLRHSIFGLGTAQVLLC
HCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
GAALAALGVYLAGLDTEAAIIIGFGLALSSTAFAMQVLEDRAETNQKHGQRAFAILLFQD
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LAIVPILAIIPALSPNEPSQASAGFHLATAIASIAALVIAGRYLINPMFRIIANTGAREV
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
MIAAALFVVLGSASLLQYAGLSMAMGAFIAGVLLAESSYRHELEADIEPFRGIFLGLFFV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHH
AVGLSLNLSVILEYWAVILAAVPIFMATKIVIIYLLCRIFRSSHNDAVRIAFLLPQGGEF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCE
AFVLFSAASAAAIISCALGSELVAAVTVSMALTPLSVAIGSRLLIKDKADDIIEENFDGA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCC
GSDVLMIGFSRYGQIAAQILLAGGIDVTVIDSSSNRVRAAGKFGFRIYFGDGTRKDVLEA
CCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEEECCCCHHHHHHH
AGIRKAKIVAICTHKKSTTNHIVNLIQSEYPDVRLFVRSYDREHTLQLRAQGVEYELRET
CCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEHHHHCCCCCEEEHHHCCCCHHHHHH
FESGLLFGQRTLEGLGLSEANAYAIREDVRQRDEDRLHVQASEGIMAGRHLLFNKPVTPE
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHCCHHEECCCCCCC
PLVKPTREGQRIDKSDDGQRAPSPQETAAAPVAAE
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
PKSGVFKATSSTIFKYQEHSMVANGGSLYLQSLMILGGAIIAAPLFKRLGLGTVLGYLA
CCCCCEECCCHHHHEEHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGITIGPVARLIADGEEFLHFSELGVVFLLFIIGLELNPSRLWSLRHSIFGLGTAQVLLC
HCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
GAALAALGVYLAGLDTEAAIIIGFGLALSSTAFAMQVLEDRAETNQKHGQRAFAILLFQD
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LAIVPILAIIPALSPNEPSQASAGFHLATAIASIAALVIAGRYLINPMFRIIANTGAREV
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
MIAAALFVVLGSASLLQYAGLSMAMGAFIAGVLLAESSYRHELEADIEPFRGIFLGLFFV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHH
AVGLSLNLSVILEYWAVILAAVPIFMATKIVIIYLLCRIFRSSHNDAVRIAFLLPQGGEF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCE
AFVLFSAASAAAIISCALGSELVAAVTVSMALTPLSVAIGSRLLIKDKADDIIEENFDGA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCC
GSDVLMIGFSRYGQIAAQILLAGGIDVTVIDSSSNRVRAAGKFGFRIYFGDGTRKDVLEA
CCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEEECCCCHHHHHHH
AGIRKAKIVAICTHKKSTTNHIVNLIQSEYPDVRLFVRSYDREHTLQLRAQGVEYELRET
CCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEHHHHCCCCCEEEHHHCCCCHHHHHH
FESGLLFGQRTLEGLGLSEANAYAIREDVRQRDEDRLHVQASEGIMAGRHLLFNKPVTPE
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHCCHHEECCCCCCC
PLVKPTREGQRIDKSDDGQRAPSPQETAAAPVAAE
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]