Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 225686035

GI number: 225686035

Start: 163183

End: 164679

Strand: Direct

Name: glcD [H]

Synonym: BMEA_B0180

Alternate gene names: 225686035

Gene position: 163183-164679 (Clockwise)

Preceding gene: 225686031

Following gene: 225686036

Centisome position: 13.76

GC content: 59.72

Gene sequence:

>1497_bases
ATGAGCGGACTCATCATGCCGGAACCGGACGCTGGCGTTTTGCAGCGGCGCGAGCAAATTGTCGCGGATTTGCGCGTCAT
CGTGCCGGGCGAAGGGGTTGTGGATACGGTCAATGCCATGCGCGTGTTCGAGACCGACGGTCTTACGGCGCACCGGCAAT
TGCCGCTGGTGGTTGTGCTGCCGGAAACGGTCGAACAGGTGGCGCAGGTTCTGCGCTATTGCCATGACAATGCCATCCGT
GTCGTGCCGCGCGGGGCGGGCACTTCGCTTTCCGGCGGCTCCATGCCGCTTGAAGATGCCGTGCTGCTCGTCATGTCGCG
CTTCAACCGCATTCTGGAAATCGATTATCCCAATCGGGTCGCCGTGGTGCAGCCTGGCGTGACCAATCTCGGCATCACCA
AGGCGGTGGAGCATGAAGGCTTTTATTATGCGCCCGACCCGTCCTCGCAGATTGCCTGCTCCATCGGCGGCAATGTGGCT
GAAAATGCGGGCGGGGTTCATTGCCTGAAATACGGCCTCACCGCCAATAATGTGCTCGGCATCGAAATGGTGCTGATTAC
CGGCGAAGTGATGCGCCTTGGCGGCAAGCATCTCGACAGCGAGGCTTATGATCTTCTTGGCCTCATGACCGGCTCTGAAG
GTCTGCTTGGCGTCGTGACCGAAATTACGGTGCGCATCCTGCAAAAGCCTGAGACGGCACGCGCAATCATGGTCGGCTTT
CCGTCGAGCGAACAGGCGGGGCAATGCGTGGCCGATATCATCGGTGCGGGCATCATTCCGGGCGGCATGGAAATGATGGA
CCGGCCTGCCATCAAGGCTGCGGAGGATTTCGTGCGTGTCGGCTATCCGCTTGATGTCGAGGCGCTTTTGATCGTCGAAC
TGGACGGCCCTCCGGTGGAGGTCGATTATCTGCTCGGCCGCGTGGAGAAGATCGCGCTTCAGAACGGTTCCACCACCTGC
ACGCTGTCGCAATCAGAAGAACAGAGGCTTGCTTTCTGGGCCGGGCGCAAGGCGGCATTTCCAGCCGTGGGGCGCATTTC
GCCCGATTATCTATGCATGGATGGCACCATTCCGCGCAAGGAATTGCCGCGTGTCCTCTCGGGGATGCGCGCGCTTTCGG
AAAAATACGGCCTGCGTGTGGCTAATGTGTTCCATGCGGGTGATGGCAATCTTCATCCGCTCATCCTTTATGACGCAAAC
AATCCGGGAGAACTGGAAGCGGCGGAGGATTTCGGCGCGGATATCCTGCGGCTTTGCGTAAAGGTTGGCGGGGTTCTCAC
CGGCGAACATGGCGTCGGCATCGAAAAGCGCGACCTGATGCCGGAAATGTTCAACGAGACCGATCTTGACCAGCAGATGC
GCGTCAAATGTGCTTTCGACGCCAAGCATTTGCTGAACCCCGGCAAGGTATTTCCGCAATTGCGCCGCTGCGCCGAACTG
GGGCGTATGCATGTGAGCCGCGGCGCGCTGGCGTTCCCCGATCTACCCCGTTTTTGA

Upstream 100 bases:

>100_bases
AATTCAGGGCGGATATGGCTTGAGGGCATGTCCCGAAAAGCAATCCGCTCAGGGGCTGGGGCGGGCTTTAAGGCAAAAGG
CGCCAGCGGTGGAGGAAGAG

Downstream 100 bases:

>100_bases
CCTGTGGTTCTGAAAATGAGCGATGCAAATATACTGAAACCGCAGGACGAGGCGGGTGTGCTGGAAATGGTGCAGGCCGC
CTTGGCAAGCTCCACGCCGC

Product: FAD binding domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSGLIMPEPDAGVLQRREQIVADLRVIVPGEGVVDTVNAMRVFETDGLTAHRQLPLVVVLPETVEQVAQVLRYCHDNAIR
VVPRGAGTSLSGGSMPLEDAVLLVMSRFNRILEIDYPNRVAVVQPGVTNLGITKAVEHEGFYYAPDPSSQIACSIGGNVA
ENAGGVHCLKYGLTANNVLGIEMVLITGEVMRLGGKHLDSEAYDLLGLMTGSEGLLGVVTEITVRILQKPETARAIMVGF
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIKAAEDFVRVGYPLDVEALLIVELDGPPVEVDYLLGRVEKIALQNGSTTC
TLSQSEEQRLAFWAGRKAAFPAVGRISPDYLCMDGTIPRKELPRVLSGMRALSEKYGLRVANVFHAGDGNLHPLILYDAN
NPGELEAAEDFGADILRLCVKVGGVLTGEHGVGIEKRDLMPEMFNETDLDQQMRVKCAFDAKHLLNPGKVFPQLRRCAEL
GRMHVSRGALAFPDLPRF

Sequences:

>Translated_498_residues
MSGLIMPEPDAGVLQRREQIVADLRVIVPGEGVVDTVNAMRVFETDGLTAHRQLPLVVVLPETVEQVAQVLRYCHDNAIR
VVPRGAGTSLSGGSMPLEDAVLLVMSRFNRILEIDYPNRVAVVQPGVTNLGITKAVEHEGFYYAPDPSSQIACSIGGNVA
ENAGGVHCLKYGLTANNVLGIEMVLITGEVMRLGGKHLDSEAYDLLGLMTGSEGLLGVVTEITVRILQKPETARAIMVGF
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIKAAEDFVRVGYPLDVEALLIVELDGPPVEVDYLLGRVEKIALQNGSTTC
TLSQSEEQRLAFWAGRKAAFPAVGRISPDYLCMDGTIPRKELPRVLSGMRALSEKYGLRVANVFHAGDGNLHPLILYDAN
NPGELEAAEDFGADILRLCVKVGGVLTGEHGVGIEKRDLMPEMFNETDLDQQMRVKCAFDAKHLLNPGKVFPQLRRCAEL
GRMHVSRGALAFPDLPRF
>Mature_497_residues
SGLIMPEPDAGVLQRREQIVADLRVIVPGEGVVDTVNAMRVFETDGLTAHRQLPLVVVLPETVEQVAQVLRYCHDNAIRV
VPRGAGTSLSGGSMPLEDAVLLVMSRFNRILEIDYPNRVAVVQPGVTNLGITKAVEHEGFYYAPDPSSQIACSIGGNVAE
NAGGVHCLKYGLTANNVLGIEMVLITGEVMRLGGKHLDSEAYDLLGLMTGSEGLLGVVTEITVRILQKPETARAIMVGFP
SSEQAGQCVADIIGAGIIPGGMEMMDRPAIKAAEDFVRVGYPLDVEALLIVELDGPPVEVDYLLGRVEKIALQNGSTTCT
LSQSEEQRLAFWAGRKAAFPAVGRISPDYLCMDGTIPRKELPRVLSGMRALSEKYGLRVANVFHAGDGNLHPLILYDANN
PGELEAAEDFGADILRLCVKVGGVLTGEHGVGIEKRDLMPEMFNETDLDQQMRVKCAFDAKHLLNPGKVFPQLRRCAELG
RMHVSRGALAFPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=459, Percent_Identity=29.6296296296296, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI37595754, Length=482, Percent_Identity=28.2157676348548, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI119964728, Length=461, Percent_Identity=30.8026030368764, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4501993, Length=246, Percent_Identity=28.0487804878049, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789351, Length=482, Percent_Identity=58.0912863070539, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1787977, Length=523, Percent_Identity=23.3269598470363, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994907, Length=221, Percent_Identity=29.8642533936652, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=464, Percent_Identity=28.6637931034483, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71992381, Length=464, Percent_Identity=28.6637931034483, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=362, Percent_Identity=27.6243093922652, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17534361, Length=426, Percent_Identity=26.5258215962441, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17556096, Length=258, Percent_Identity=24.4186046511628, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320027, Length=475, Percent_Identity=28.6315789473684, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320023, Length=459, Percent_Identity=25.4901960784314, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320764, Length=490, Percent_Identity=23.8775510204082, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI18921117, Length=429, Percent_Identity=27.972027972028, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639277, Length=429, Percent_Identity=27.972027972028, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639275, Length=429, Percent_Identity=27.972027972028, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653753, Length=220, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53782; Mature: 53651

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLIMPEPDAGVLQRREQIVADLRVIVPGEGVVDTVNAMRVFETDGLTAHRQLPLVVVL
CCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHEEEEECCCCCCCCCCCEEEEC
PETVEQVAQVLRYCHDNAIRVVPRGAGTSLSGGSMPLEDAVLLVMSRFNRILEIDYPNRV
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCEE
AVVQPGVTNLGITKAVEHEGFYYAPDPSSQIACSIGGNVAENAGGVHCLKYGLTANNVLG
EEECCCCCCCCCHHHHCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEE
IEMVLITGEVMRLGGKHLDSEAYDLLGLMTGSEGLLGVVTEITVRILQKPETARAIMVGF
EEEEEEEHHHHHHCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIKAAEDFVRVGYPLDVEALLIVELDGPPVE
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCEE
VDYLLGRVEKIALQNGSTTCTLSQSEEQRLAFWAGRKAAFPAVGRISPDYLCMDGTIPRK
HHHHHHHHHHEEECCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHH
ELPRVLSGMRALSEKYGLRVANVFHAGDGNLHPLILYDANNPGELEAAEDFGADILRLCV
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHH
KVGGVLTGEHGVGIEKRDLMPEMFNETDLDQQMRVKCAFDAKHLLNPGKVFPQLRRCAEL
HHCCEEECCCCCCCCHHHCCHHHCCCCCCCHHHEEEEEECHHHHCCCHHHHHHHHHHHHH
GRMHVSRGALAFPDLPRF
HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SGLIMPEPDAGVLQRREQIVADLRVIVPGEGVVDTVNAMRVFETDGLTAHRQLPLVVVL
CCCCCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHEEEEECCCCCCCCCCCEEEEC
PETVEQVAQVLRYCHDNAIRVVPRGAGTSLSGGSMPLEDAVLLVMSRFNRILEIDYPNRV
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCEE
AVVQPGVTNLGITKAVEHEGFYYAPDPSSQIACSIGGNVAENAGGVHCLKYGLTANNVLG
EEECCCCCCCCCHHHHCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEE
IEMVLITGEVMRLGGKHLDSEAYDLLGLMTGSEGLLGVVTEITVRILQKPETARAIMVGF
EEEEEEEHHHHHHCCCCCCCHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
PSSEQAGQCVADIIGAGIIPGGMEMMDRPAIKAAEDFVRVGYPLDVEALLIVELDGPPVE
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCEE
VDYLLGRVEKIALQNGSTTCTLSQSEEQRLAFWAGRKAAFPAVGRISPDYLCMDGTIPRK
HHHHHHHHHHEEECCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHH
ELPRVLSGMRALSEKYGLRVANVFHAGDGNLHPLILYDANNPGELEAAEDFGADILRLCV
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHH
KVGGVLTGEHGVGIEKRDLMPEMFNETDLDQQMRVKCAFDAKHLLNPGKVFPQLRRCAEL
HHCCEEECCCCCCCCHHHCCHHHCCCCCCCHHHEEEEEECHHHHCCCHHHHHHHHHHHHH
GRMHVSRGALAFPDLPRF
HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]