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The map label for this gene is ldc [H]

Identifier: 225685964

GI number: 225685964

Start: 97529

End: 98662

Strand: Direct

Name: ldc [H]

Synonym: BMEA_B0103

Alternate gene names: 225685964

Gene position: 97529-98662 (Clockwise)

Preceding gene: 225685959

Following gene: 225685970

Centisome position: 8.23

GC content: 60.14

Gene sequence:

>1134_bases
ATGGCAACGCAGCGTATTATCGATTTCCTCAACACCCGCCGTCCCGAAGGCCCTTGCCTCGTCGTCGATACCGATGTCGT
GCGCGAAAACTATCAGGGCTTTGAAAAAGCTTTGCCTTATTCGCGCATTTTCTATGCGGTGAAGGCCAATCCCGCGCCGG
AAATCCTGCGCCTGCTCGCTTCGCTCGGCTCTTCTTTCGACACGGCCTCGGTTGCTGAAATCGAAATGGCGCTGGAAGCA
GGCGCGACACCAGACCGTATCTCTTATGGCAACACCATCAAGAAAGAGCGCGATATTGCGCGCGCCTTCGATCTGGGCAT
CCGCCTTTATGCGGTCGATTGCGTGGAAGAAGTGGAAAAGATTGCCCGCGTCGCGCCCGGCAGCCGCGTGTTCTGCCGCG
TCCTGACCGATGGCGAAGGTGCCAAATGGCCGCTTTCGCGCAAGTTTGGTTGCGTGCCTGCCATGGCGAAGGACGTGCTG
CGCCGCGCCAAGGCGCTCGGCCTCGATGCTTACGGCGTGTCGTTCCACGTCGGCTCGCAGCAGACGGATCTCACGGCTTG
GGATCGTGCGCTGGCTGACGCGGCAGCGGTCTTCCGCACGCTTGCCGATGAGGGCATCATCTTGCGCATGGTCAATATGG
GCGGCGGTTTTCCGACGCGCTATCTCAAGGATGTGCCGACCGCACAGGCCTATGGCATGGCGATCTTCGACGCGCTGTCC
CGGCATTTCGGCAACCGCATCCCGGAAACCATCATCGAGCCGGGCCGCGGCATGGTGGGCAATGCAGGCGTCATCAAGAC
CGAGGTGGTGCTGGTTTCGCGCAAGGCGGACAACGACAATGTGCGCTGGGTCTATCTCGACATCGGCAAGTTTGGTGGTC
TGGCCGAAACCATGGACGAGGCGATCCGCTACCAGATCGTGACCCCGCATGACGGCAGCGAAACCGAACCTTGTGTCCTG
GCTGGCCCGACCTGCGACAGTGCCGACGTACTTTATGAAAAGACGCCTTACCCGTTGCCGGTCTCGCTGACCATCGGTGA
TGAGATTCTCATCGAAGGCACGGGCGCTTACACCACCACCTATTCGGCGGTGGCGTTCAACGGGTTTGAACCGTTGCGAT
CCTATGTCATCTGA

Upstream 100 bases:

>100_bases
GTGACATCAGCATCTTCACAGACTGGCTTCACTGCGGGGGCGTTTATGCATCTTTGTCCCCCTCGTAAGCGGTAAAAACG
GGCCGCGTGGGAGAGCAACC

Downstream 100 bases:

>100_bases
TCTTTAGAGGGTTCCTGTTTTAATGGAACCCTCTAACTATGCGTAGGCGTTTCGCACTTTTGGCTCGAAAATGCTCTACA
GGCGCAGCAACCGCCCGAAA

Product: Lysine/ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MATQRIIDFLNTRRPEGPCLVVDTDVVRENYQGFEKALPYSRIFYAVKANPAPEILRLLASLGSSFDTASVAEIEMALEA
GATPDRISYGNTIKKERDIARAFDLGIRLYAVDCVEEVEKIARVAPGSRVFCRVLTDGEGAKWPLSRKFGCVPAMAKDVL
RRAKALGLDAYGVSFHVGSQQTDLTAWDRALADAAAVFRTLADEGIILRMVNMGGGFPTRYLKDVPTAQAYGMAIFDALS
RHFGNRIPETIIEPGRGMVGNAGVIKTEVVLVSRKADNDNVRWVYLDIGKFGGLAETMDEAIRYQIVTPHDGSETEPCVL
AGPTCDSADVLYEKTPYPLPVSLTIGDEILIEGTGAYTTTYSAVAFNGFEPLRSYVI

Sequences:

>Translated_377_residues
MATQRIIDFLNTRRPEGPCLVVDTDVVRENYQGFEKALPYSRIFYAVKANPAPEILRLLASLGSSFDTASVAEIEMALEA
GATPDRISYGNTIKKERDIARAFDLGIRLYAVDCVEEVEKIARVAPGSRVFCRVLTDGEGAKWPLSRKFGCVPAMAKDVL
RRAKALGLDAYGVSFHVGSQQTDLTAWDRALADAAAVFRTLADEGIILRMVNMGGGFPTRYLKDVPTAQAYGMAIFDALS
RHFGNRIPETIIEPGRGMVGNAGVIKTEVVLVSRKADNDNVRWVYLDIGKFGGLAETMDEAIRYQIVTPHDGSETEPCVL
AGPTCDSADVLYEKTPYPLPVSLTIGDEILIEGTGAYTTTYSAVAFNGFEPLRSYVI
>Mature_376_residues
ATQRIIDFLNTRRPEGPCLVVDTDVVRENYQGFEKALPYSRIFYAVKANPAPEILRLLASLGSSFDTASVAEIEMALEAG
ATPDRISYGNTIKKERDIARAFDLGIRLYAVDCVEEVEKIARVAPGSRVFCRVLTDGEGAKWPLSRKFGCVPAMAKDVLR
RAKALGLDAYGVSFHVGSQQTDLTAWDRALADAAAVFRTLADEGIILRMVNMGGGFPTRYLKDVPTAQAYGMAIFDALSR
HFGNRIPETIIEPGRGMVGNAGVIKTEVVLVSRKADNDNVRWVYLDIGKFGGLAETMDEAIRYQIVTPHDGSETEPCVLA
GPTCDSADVLYEKTPYPLPVSLTIGDEILIEGTGAYTTTYSAVAFNGFEPLRSYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=372, Percent_Identity=33.0645161290323, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI16506287, Length=354, Percent_Identity=29.6610169491525, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789203, Length=377, Percent_Identity=27.3209549071618, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562780, Length=374, Percent_Identity=32.0855614973262, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25141365, Length=362, Percent_Identity=22.3756906077348, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322664, Length=380, Percent_Identity=31.3157894736842, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24586472, Length=380, Percent_Identity=30.2631578947368, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24586474, Length=359, Percent_Identity=29.5264623955432, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41152; Mature: 41021

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQRIIDFLNTRRPEGPCLVVDTDVVRENYQGFEKALPYSRIFYAVKANPAPEILRLLA
CCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHH
SLGSSFDTASVAEIEMALEAGATPDRISYGNTIKKERDIARAFDLGIRLYAVDCVEEVEK
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHH
IARVAPGSRVFCRVLTDGEGAKWPLSRKFGCVPAMAKDVLRRAKALGLDAYGVSFHVGSQ
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC
QTDLTAWDRALADAAAVFRTLADEGIILRMVNMGGGFPTRYLKDVPTAQAYGMAIFDALS
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHH
RHFGNRIPETIIEPGRGMVGNAGVIKTEVVLVSRKADNDNVRWVYLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYQIVTPHDGSETEPCVLAGPTCDSADVLYEKTPYPLPVSLTIGDEILIEGTGAYTTT
HHEEEEECCCCCCCCCCEEEECCCCCCCCCEECCCCCCCEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLRSYVI
EHHEEECCHHHHHHHCC
>Mature Secondary Structure 
ATQRIIDFLNTRRPEGPCLVVDTDVVRENYQGFEKALPYSRIFYAVKANPAPEILRLLA
CHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHH
SLGSSFDTASVAEIEMALEAGATPDRISYGNTIKKERDIARAFDLGIRLYAVDCVEEVEK
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHH
IARVAPGSRVFCRVLTDGEGAKWPLSRKFGCVPAMAKDVLRRAKALGLDAYGVSFHVGSQ
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC
QTDLTAWDRALADAAAVFRTLADEGIILRMVNMGGGFPTRYLKDVPTAQAYGMAIFDALS
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHH
RHFGNRIPETIIEPGRGMVGNAGVIKTEVVLVSRKADNDNVRWVYLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYQIVTPHDGSETEPCVLAGPTCDSADVLYEKTPYPLPVSLTIGDEILIEGTGAYTTT
HHEEEEECCCCCCCCCCEEEECCCCCCCCCEECCCCCCCEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLRSYVI
EHHEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]