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The map label for this gene is hemH [H]

Identifier: 225685943

GI number: 225685943

Start: 74757

End: 75815

Strand: Reverse

Name: hemH [H]

Synonym: BMEA_B0080

Alternate gene names: 225685943

Gene position: 75815-74757 (Counterclockwise)

Preceding gene: 225685944

Following gene: 225685942

Centisome position: 6.4

GC content: 58.07

Gene sequence:

>1059_bases
ATGAGTGGAACGGACAAGGTGCGTGTGAACGTCAGCCAGACAGCGCAGACCCCGCTGCATACATCGGCCAAACTGCCGAA
AGTCGGGGTTTTGCTGGTCAATCTCGGCACGCCGGACGGCACGAGCTACGGCCCGATGCGGCGCTATCTTGCCGAATTTC
TCTCCGACCGCCGCGTCATCGAATGGTCGCGCCTTATCTGGTACCCGATCCTTTACGGTATTGTTCTCAACACACGGCCC
AGGCGTTCCGGCAGGCTCTATGATCGCATCTGGAATCACGAGAATAATGAATCGCCCCTGCGCACCTATACGCGCGCGCA
GGGCGAGAAACTTGCCAAAGCACTTAGCGACCAACCCAATGTCGTGGTGGACTGGGCGATGCGCTATGGCCAGCCTTCCA
TCGAGAGCATAACCGACCGCCTGCTTCAGCAGGGCTGCGAGCGGATTGTGATATTCCCGCTCTATCCGCAATATTCCGCC
ACTACCACGGCGACGGTGAACGACAAGTTCTTCGAGGCGCTGATGAAAAAGCGCTTCATGCCTGCAATCCGCACCGTGCC
GTCATACGAGGCCGAGCCGGTCTATATCGACGCGCTGGCGCGTTCCGTCGAAAAGCATCTGGCTACGCTTTCCTTCAAGC
CCGAAGTCATCCTCACCTCCTATCACGGCATTCCGAAAAGCTATTCGGACAAGGGCGACCCCTATCGCCAGCAATGCCTT
GAAACGACGCGGCTTCTGCGTGAGCGCCTCGGCCTTGGCGAAGACGAGATGCGCGCCACCTTCCAGTCACGCTTCGGCCC
GGAAGAATGGCTCCAGCCCTATACCGACGAAACCGTGAAGGAACTGGCCAAAAACGGCGTCAAATCGGTGGCGGTGCTCA
ATCCTGGTTTCGTGGCCGATTGCCTGGAAACGGTGGACGAAATCGGCAATGAGGCAGCGGAAGAGTTTCTTGAAAACGGC
GGCGAAAACTTCAGCCATATTCCCTGCCTCAACGATAGCGAAGAGGGCATGAAGGTCATTGAGACGCTGGTGCGCCGCGA
ATTGCTGGGATGGGTTTAG

Upstream 100 bases:

>100_bases
GTTTCCCTGCCCGTTACACACGATCCGATAAACAACGATTTGTCAGGATTGTAATTTGTCTTTTTTTCTCTAGTTTTCTG
GCAGAACATGGAGTCGGAAT

Downstream 100 bases:

>100_bases
ATGAAAGGCAGTAGGGCAGTAAGGGAATAAGGCAGTATGTTTTGATCTGTGGTAAACTCCACTTACTGCCCTACTGCAAT
ATTGCCTTATTCCCTTATTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVIEWSRLIWYPILYGIVLNTRP
RRSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSA
TTTATVNDKFFEALMKKRFMPAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCL
ETTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVADCLETVDEIGNEAAEEFLENG
GENFSHIPCLNDSEEGMKVIETLVRRELLGWV

Sequences:

>Translated_352_residues
MSGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVIEWSRLIWYPILYGIVLNTRP
RRSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSA
TTTATVNDKFFEALMKKRFMPAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCL
ETTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVADCLETVDEIGNEAAEEFLENG
GENFSHIPCLNDSEEGMKVIETLVRRELLGWV
>Mature_351_residues
SGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVIEWSRLIWYPILYGIVLNTRPR
RSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSAT
TTATVNDKFFEALMKKRFMPAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCLE
TTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVADCLETVDEIGNEAAEEFLENGG
ENFSHIPCLNDSEEGMKVIETLVRRELLGWV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=363, Percent_Identity=26.4462809917355, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI60499025, Length=354, Percent_Identity=26.5536723163842, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=45.2830188679245, Blast_Score=272, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324750, Length=351, Percent_Identity=23.0769230769231, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17864156, Length=309, Percent_Identity=24.2718446601942, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24651774, Length=268, Percent_Identity=23.8805970149254, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40057; Mature: 39926

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVI
CCCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHH
EWSRLIWYPILYGIVLNTRPRRSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSATTTATVNDKFFEALMKKRFM
EEEHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHH
PAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
ETTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVAD
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHH
CLETVDEIGNEAAEEFLENGGENFSHIPCLNDSEEGMKVIETLVRRELLGWV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVI
CCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHH
EWSRLIWYPILYGIVLNTRPRRSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSATTTATVNDKFFEALMKKRFM
EEEHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHH
PAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHH
ETTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVAD
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHH
CLETVDEIGNEAAEEFLENGGENFSHIPCLNDSEEGMKVIETLVRRELLGWV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA