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The map label for this gene is cycA [H]

Identifier: 225685923

GI number: 225685923

Start: 53138

End: 54541

Strand: Reverse

Name: cycA [H]

Synonym: BMEA_B0060

Alternate gene names: 225685923

Gene position: 54541-53138 (Counterclockwise)

Preceding gene: 225685924

Following gene: 225685920

Centisome position: 4.6

GC content: 53.13

Gene sequence:

>1404_bases
ATGAATACTATATCAAAGCCTTCCGTTGATTTGCACCGGGAGGAGGAACCTCATCTTGCACGTAATCTATCCAATCGACA
CCTCCAGCTGATCGCCATCGGCGGCACGATCGGCACCGGCCTTTTCATGGGGTCGGGCAAAGCCGTTTCGCTGGCGGGGC
CTTCGATCCTGCTCATCTATGCGATCACCGGCTTCATGCTGTTTTTCGTCATGCGCGCGCTGGGCGAAATTCTGCTTTCC
AACCTGCAATATCGCTCCTTCGCGGACTTCGCGGGTGACTATCTGGGGCCATGCGCACAATTTTTCACCGGCTGGACCTA
CTGGCTATGCTGGATCGTGACGGCCGTGGCCGAAGTCGTGGCCGTTCCCGGCTATGTCTCATTCTGGTTTCCTCATCTGG
CGCCGTGGATCCCGGCCCTCGGCCTCATCACAATACTGCTGATACTGAATCTGCCGACCGTGCGCAATTTTGGTGAAATC
GAATTCTGGTTCGCCCTCATCAAAATTATCACCATTATCGGGCTGATTATTACTGGCATATACATGCTCATGACGGGCTT
TGTCTTGCCCAATGGCACCCAGGCATCAATTGCCCATCTGTGGAACCATGGCGGGTTCTTCCCCAATGGTTCTCTTGGCT
TTATCGCCGGGTTCCAGATATCGGTTTTTGCTTTCGTCGGTATCGAACTCGTGGGCACGGCTGCTGCGGAGGCCGAAAAC
CCGATGCGAAACCTGCCGAAGGCGATCAATAATATCCCGATCCGTATCGTTCTTTTTTATATTGGCGCGCTGTTTGTCAT
CATCACCGTCACTCCGTGGAATCAGGTGGACCCGAATTCAAGTCCCTTCGTGGCCATGTTCTCGCTCGCCGGTATCGGCA
TAGCAGCCCATTTCATAAATTTTGTCGTTCTGACTTCGGCATCGTCGAGTTCAAATTCCGGCATCTACTCGACCTCGCGC
ATGGTCTACGGCCTTGCCACTGTCGGGCTTGCACCGAAAGCCTTCAGTAAACTGAGCAATCGCAAGGTGCCGGTCCACGC
GCTAATCTTCTCTTGCATATTCCTGCTGTCGAGCGTGGTTCTGCTTTATGCAGGCCAGAGCATGATCCAGGTCTTCACAC
TCGTCACGACGATTTCGGCGCTCCTGTTCATTTTCATCTGGTCGATTATCCTGGTGTCTTACCTGCAATATCGCCGCAAG
CACCCCGAACGGCATGAAAAATCCACCTTCAAGATGCCCGGTGGACGTGCATCTGTCGTTATGGTCTTCATTTTCTTTGC
CTTCGTCCTTTGGGCGCTGACACAGGAACCGGATACGTTAGCCGCGATGAAAGTCACGCCATTGTGGTTCGTGCTTCTGG
GCATTGCCTATTGGGTCATGAAATTAAAGCAAAAGCAGAGCTAA

Upstream 100 bases:

>100_bases
AGAAAGCGTCGTGTGCCTGAAACGACATATAGGAGAGGGTGCAGCTACGCGCATTCGCGCGCAGTGTGATTATGCGTTTA
CCAACATAAGAGGCGCTTGC

Downstream 100 bases:

>100_bases
AAAATATGAAGCCCGCCATTTGGCGGGCTTTCCATGCACATCTCTCAACGAGGCAAAACGGAACTGCCCATCAAATCCGC
ATCAATAGCATGGGCTGCCT

Product: amino acid permease-associated protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVPGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNGTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGGRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS

Sequences:

>Translated_467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVPGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNGTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGGRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
>Mature_467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVPGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNGTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGGRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=363, Percent_Identity=26.9972451790634, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI114326544, Length=436, Percent_Identity=22.2477064220184, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI114326550, Length=436, Percent_Identity=22.2477064220184, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI258645169, Length=504, Percent_Identity=23.015873015873, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI258614005, Length=389, Percent_Identity=23.9074550128535, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614003, Length=505, Percent_Identity=23.3663366336634, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507047, Length=441, Percent_Identity=23.3560090702948, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI181337167, Length=363, Percent_Identity=22.038567493113, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=452, Percent_Identity=60.3982300884956, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1786789, Length=466, Percent_Identity=38.8412017167382, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1786302, Length=448, Percent_Identity=39.0625, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=39.7802197802198, Blast_Score=324, Evalue=7e-90,
Organism=Escherichia coli, GI48994972, Length=399, Percent_Identity=43.609022556391, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=38.0246913580247, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=37.2208436724566, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87081708, Length=395, Percent_Identity=33.9240506329114, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI1789017, Length=404, Percent_Identity=31.9306930693069, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=24.5327102803738, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=377, Percent_Identity=25.7294429708223, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=402, Percent_Identity=24.6268656716418, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324924, Length=424, Percent_Identity=33.4905660377358, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=432, Percent_Identity=30.787037037037, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=32.0276497695853, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=423, Percent_Identity=31.6784869976359, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=416, Percent_Identity=31.9711538461538, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=426, Percent_Identity=30.0469483568075, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319824, Length=411, Percent_Identity=29.683698296837, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=30.5343511450382, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=411, Percent_Identity=29.4403892944039, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6320717, Length=416, Percent_Identity=26.4423076923077, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=401, Percent_Identity=28.6783042394015, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=419, Percent_Identity=26.9689737470167, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=422, Percent_Identity=30.3317535545024, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=406, Percent_Identity=29.3103448275862, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=398, Percent_Identity=27.1356783919598, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=414, Percent_Identity=28.2608695652174, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=413, Percent_Identity=29.2978208232446, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=464, Percent_Identity=24.3534482758621, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666159, Length=439, Percent_Identity=22.0956719817768, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221512776, Length=439, Percent_Identity=22.0956719817768, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668806, Length=432, Percent_Identity=22.4537037037037, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356285, Length=432, Percent_Identity=22.4537037037037, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24668802, Length=432, Percent_Identity=22.4537037037037, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667468, Length=410, Percent_Identity=23.4146341463415, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51471; Mature: 51471

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHEEECCCCEEEECCCHHHHHH
AITGFMLFFVMRALGEILLSNLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEIEFWFALIKIITIIGLIITGI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMLMTGFVLPNGTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVVLTSASSSSNSGIYSTSRMVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVV
HHHEECCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRKHPERHEKSTFKMPGGRASVV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHH
MVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHEEECCCCEEEECCCHHHHHH
AITGFMLFFVMRALGEILLSNLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEIEFWFALIKIITIIGLIITGI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMLMTGFVLPNGTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVVLTSASSSSNSGIYSTSRMVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVV
HHHEECCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRKHPERHEKSTFKMPGGRASVV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHH
MVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]