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The map label for this gene is hisN [H]

Identifier: 225685912

GI number: 225685912

Start: 41372

End: 42148

Strand: Direct

Name: hisN [H]

Synonym: BMEA_B0048

Alternate gene names: 225685912

Gene position: 41372-42148 (Clockwise)

Preceding gene: 225685911

Following gene: 225685916

Centisome position: 3.49

GC content: 61.13

Gene sequence:

>777_bases
TTGCTGATCGACAAGGCATTTTTTTCGGAAGTGGCGGCAGCCGCAGCAGCGCAAACCCTGCCGCGTTTTCGTCAATTGAC
GGAAGTGGACAATAAATACAGCGTCGGTTTCGACCCGGTGACGGAGGCCGACCGCGCTGCGGAAAGGGCAATTCGCGCTG
TTATCGGGCGCACTTTTCCCGATCATGGCATTCTGGGCGAGGAATATGGGGCGGAAAACACCGACCGCAGCCATGTCTGG
ATCATCGATCCGGTGGATGGTACGCGCGCTTTCATTTCGGGCCTGCCGGTCTGGGGCACGCTGGTGGGCCTTACGGTGGA
TGGCGACGCCAGGGCCGGGATGATGTCGCAGCCCTTCACGGGCGAGCTTTTCTATAGCGACGGTGACGGCGCCTATCTCC
AGCGGGGCGACGGTGCGCCGCGCCGCCTTTGCGTGCGCAAGAATGCGGTGCTGGAAGACGCAACACTTTTCACGACCACG
CCCGCCCTTTTCAAGGGCGATGATCGCAAGGCTTTTGACCGGCTGGAAAGCGCCGTGCGCCTGTCGCGTTATGGCGTGGA
TTGCTATGCTTTCGCGATGCTGGCGGGCGGTTTTGTGGATATTGTGGTGGAAGCCGGTTTACAGACCTATGATATTGCCG
CGCTCATTCCCATTATCGAGCAGGCAGGTGGCGTGGTGACACGGCGCGACGGAGGGCCGGCAGAGCAGGGCGGGGATATC
GTGGCGGCTGCAACGCCTGCGCTGCATCAGGCCGCACTGGATCTGCTCCATATCTAA

Upstream 100 bases:

>100_bases
CTAACGAAAACCGTTTTATATTTTTGGCTCGGAAATGCTCTGGGCAAAATTGGCATAGTTGCACGCAAGAGCGCCATGTT
TTGGAAACAGGAGAACAGGG

Downstream 100 bases:

>100_bases
ACCATGTCGCATATATTGCCGCGAAGGCTGCTCCCATTTTGGGGCAGGCTTTAGATTTGAGAGAGGTCGGGTTCAAGACT
TTGGGGCATGGATTCCACCG

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLIDKAFFSEVAAAAAAQTLPRFRQLTEVDNKYSVGFDPVTEADRAAERAIRAVIGRTFPDHGILGEEYGAENTDRSHVW
IIDPVDGTRAFISGLPVWGTLVGLTVDGDARAGMMSQPFTGELFYSDGDGAYLQRGDGAPRRLCVRKNAVLEDATLFTTT
PALFKGDDRKAFDRLESAVRLSRYGVDCYAFAMLAGGFVDIVVEAGLQTYDIAALIPIIEQAGGVVTRRDGGPAEQGGDI
VAAATPALHQAALDLLHI

Sequences:

>Translated_258_residues
MLIDKAFFSEVAAAAAAQTLPRFRQLTEVDNKYSVGFDPVTEADRAAERAIRAVIGRTFPDHGILGEEYGAENTDRSHVW
IIDPVDGTRAFISGLPVWGTLVGLTVDGDARAGMMSQPFTGELFYSDGDGAYLQRGDGAPRRLCVRKNAVLEDATLFTTT
PALFKGDDRKAFDRLESAVRLSRYGVDCYAFAMLAGGFVDIVVEAGLQTYDIAALIPIIEQAGGVVTRRDGGPAEQGGDI
VAAATPALHQAALDLLHI
>Mature_258_residues
MLIDKAFFSEVAAAAAAQTLPRFRQLTEVDNKYSVGFDPVTEADRAAERAIRAVIGRTFPDHGILGEEYGAENTDRSHVW
IIDPVDGTRAFISGLPVWGTLVGLTVDGDARAGMMSQPFTGELFYSDGDGAYLQRGDGAPRRLCVRKNAVLEDATLFTTT
PALFKGDDRKAFDRLESAVRLSRYGVDCYAFAMLAGGFVDIVVEAGLQTYDIAALIPIIEQAGGVVTRRDGGPAEQGGDI
VAAATPALHQAALDLLHI

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=261, Percent_Identity=30.6513409961686, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI5031789, Length=211, Percent_Identity=25.5924170616114, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI221625487, Length=211, Percent_Identity=25.5924170616114, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1788882, Length=224, Percent_Identity=32.1428571428571, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=220, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI193202570, Length=223, Percent_Identity=33.6322869955157, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320493, Length=220, Percent_Identity=28.1818181818182, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357957, Length=232, Percent_Identity=30.6034482758621, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24664922, Length=227, Percent_Identity=27.7533039647577, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664918, Length=223, Percent_Identity=27.8026905829596, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357329, Length=237, Percent_Identity=32.0675105485232, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664926, Length=238, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27636; Mature: 27636

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDKAFFSEVAAAAAAQTLPRFRQLTEVDNKYSVGFDPVTEADRAAERAIRAVIGRTFP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCC
DHGILGEEYGAENTDRSHVWIIDPVDGTRAFISGLPVWGTLVGLTVDGDARAGMMSQPFT
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCCCCCCCCCCCCC
GELFYSDGDGAYLQRGDGAPRRLCVRKNAVLEDATLFTTTPALFKGDDRKAFDRLESAVR
CEEEEECCCCCEEECCCCCHHHHHHHHCCHHCCCEEEEECCHHHCCCCHHHHHHHHHHHH
LSRYGVDCYAFAMLAGGFVDIVVEAGLQTYDIAALIPIIEQAGGVVTRRDGGPAEQGGDI
HHHCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCE
VAAATPALHQAALDLLHI
EEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MLIDKAFFSEVAAAAAAQTLPRFRQLTEVDNKYSVGFDPVTEADRAAERAIRAVIGRTFP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCC
DHGILGEEYGAENTDRSHVWIIDPVDGTRAFISGLPVWGTLVGLTVDGDARAGMMSQPFT
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCCCCCCCCCCCCC
GELFYSDGDGAYLQRGDGAPRRLCVRKNAVLEDATLFTTTPALFKGDDRKAFDRLESAVR
CEEEEECCCCCEEECCCCCHHHHHHHHCCHHCCCEEEEECCHHHCCCCHHHHHHHHHHHH
LSRYGVDCYAFAMLAGGFVDIVVEAGLQTYDIAALIPIIEQAGGVVTRRDGGPAEQGGDI
HHHCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCE
VAAATPALHQAALDLLHI
EEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]