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The map label for this gene is livM [H]

Identifier: 225685894

GI number: 225685894

Start: 23142

End: 24362

Strand: Direct

Name: livM [H]

Synonym: BMEA_B0028

Alternate gene names: 225685894

Gene position: 23142-24362 (Clockwise)

Preceding gene: 225685893

Following gene: 225685895

Centisome position: 1.95

GC content: 61.34

Gene sequence:

>1221_bases
ATGACCATCAAGCAGTCGGTCGTTGCGCTCCTCGTTGTCGCACTCCTTGTCGCCCTGCCATATCTCGTCTCGGAATCGAT
GACGAATGCGGCAATCCAGATGTTGATCGCAGCCCTTTTCGCAACGGCTTTCAGCCTGCTTTGCGGGCAGGCGGGCATGT
TGTCCTTCGGCCACGCGGCCTATTTCGGCCTCGGCTCTTTTGCCGCCGTCCACGTCATGAACGCTTTTGGTGGCGAGGGC
CTGTTGCCTACGCCGCTCCTGCCGCTGGCAGGCGCAGGCGTCGGCCTCCTGTCGGGCCTTGTTGCGGGCTGGTTCTCCAC
CAAGCGCACCGGCGTCTATTTCGCCATGATCACGCTGGCGCTTGCTGAACTTCTCCATGCGCTTGCGCCGCATCTGAAAG
GCACGTTTGGCGGCGAGGCGGGCGTGTCCTCGTTCCGTATGCCTGCGTGGGGTTTCGATTTCGGCTCCACGACGGAAGTC
TATTATCTGGCGCTCGCCTGGGTCGTGGGGTCGATCCTGCTTCTCTTCCTCCTCACGCTGACGCCCTTTGGCCGGGTGAC
GGTGGGCCTGCGCGAAAACACCCATCGCCTGCGCTTCCTCGGCTATAATGTCCATGTGCTCGGCACGCTGGTCTTCGCCA
TTTCCGCCATGTTCGCAGGCATTGCCGGCGCCTTGCAGGCCATCAATATCGAAGCGGCCAATTATGTGGTCTTTGAAGCG
GGCATTTCGACCGCTGTGGTTCTCAACAGCTTCATCGGCGGTGTCGGCACCTTCTTCGGCCCGGCCATCGGTGCTGCGGC
CATGACGTTCTTCGGCCATCTCACCTCCGATGTCACACGCTCGTGGCTGCTCTATCAGGGCCTCATCTTGGTGCTTGTCA
TGATGTTCCTGCCGCGCGGTCTCGTCGGAGAAGCGGTCGAGCGTTTCAGGAACCCGAAGGGTACGGGCATTTCGCTTGGC
CATGCGCTGGGGCGTCTTGTGGCGCTTCTGGTGACAGCCGCCGGCACGATCATGATCGTGGAACTGGTACAGCGTTTCTT
TTCCAGCGATTACAAGGCGCTCGCTTCGGCAGGAAACTGGCCTCCGGTCACATCCCTTGGCCGCGAATGGCTGCCTTTCG
CCGTGTCCACATGGCTGATCCCCCTGGCGCTTTTCGCCGCTGGCATCGCCCTTCTCACCATCGTCAATCGCCATAGGGCC
AAAGCCAAGGGAGAGGCATGA

Upstream 100 bases:

>100_bases
GCTGGAAGTCTCCAGCATTGCAGCCACCCTGCCATTCTTCCTGATGCTTATCGTTCTCCTGGTACGTCCAAGCGGACTGT
TCGGGGCAAAGGAGTAAACC

Downstream 100 bases:

>100_bases
TGACGAAGGATATTCTCGTTCTCGATCAGCTGAACAAGTCTTTCGGCCCGGCCCACATCATTCGCGGCGTCAATCTTGCC
GTTCGTGATGGTGAGCGCCA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTIKQSVVALLVVALLVALPYLVSESMTNAAIQMLIAALFATAFSLLCGQAGMLSFGHAAYFGLGSFAAVHVMNAFGGEG
LLPTPLLPLAGAGVGLLSGLVAGWFSTKRTGVYFAMITLALAELLHALAPHLKGTFGGEAGVSSFRMPAWGFDFGSTTEV
YYLALAWVVGSILLLFLLTLTPFGRVTVGLRENTHRLRFLGYNVHVLGTLVFAISAMFAGIAGALQAINIEAANYVVFEA
GISTAVVLNSFIGGVGTFFGPAIGAAAMTFFGHLTSDVTRSWLLYQGLILVLVMMFLPRGLVGEAVERFRNPKGTGISLG
HALGRLVALLVTAAGTIMIVELVQRFFSSDYKALASAGNWPPVTSLGREWLPFAVSTWLIPLALFAAGIALLTIVNRHRA
KAKGEA

Sequences:

>Translated_406_residues
MTIKQSVVALLVVALLVALPYLVSESMTNAAIQMLIAALFATAFSLLCGQAGMLSFGHAAYFGLGSFAAVHVMNAFGGEG
LLPTPLLPLAGAGVGLLSGLVAGWFSTKRTGVYFAMITLALAELLHALAPHLKGTFGGEAGVSSFRMPAWGFDFGSTTEV
YYLALAWVVGSILLLFLLTLTPFGRVTVGLRENTHRLRFLGYNVHVLGTLVFAISAMFAGIAGALQAINIEAANYVVFEA
GISTAVVLNSFIGGVGTFFGPAIGAAAMTFFGHLTSDVTRSWLLYQGLILVLVMMFLPRGLVGEAVERFRNPKGTGISLG
HALGRLVALLVTAAGTIMIVELVQRFFSSDYKALASAGNWPPVTSLGREWLPFAVSTWLIPLALFAAGIALLTIVNRHRA
KAKGEA
>Mature_405_residues
TIKQSVVALLVVALLVALPYLVSESMTNAAIQMLIAALFATAFSLLCGQAGMLSFGHAAYFGLGSFAAVHVMNAFGGEGL
LPTPLLPLAGAGVGLLSGLVAGWFSTKRTGVYFAMITLALAELLHALAPHLKGTFGGEAGVSSFRMPAWGFDFGSTTEVY
YLALAWVVGSILLLFLLTLTPFGRVTVGLRENTHRLRFLGYNVHVLGTLVFAISAMFAGIAGALQAINIEAANYVVFEAG
ISTAVVLNSFIGGVGTFFGPAIGAAAMTFFGHLTSDVTRSWLLYQGLILVLVMMFLPRGLVGEAVERFRNPKGTGISLGH
ALGRLVALLVTAAGTIMIVELVQRFFSSDYKALASAGNWPPVTSLGREWLPFAVSTWLIPLALFAAGIALLTIVNRHRAK
AKGEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=328, Percent_Identity=24.6951219512195, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42758; Mature: 42627

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKQSVVALLVVALLVALPYLVSESMTNAAIQMLIAALFATAFSLLCGQAGMLSFGHAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YFGLGSFAAVHVMNAFGGEGLLPTPLLPLAGAGVGLLSGLVAGWFSTKRTGVYFAMITLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAELLHALAPHLKGTFGGEAGVSSFRMPAWGFDFGSTTEVYYLALAWVVGSILLLFLLTL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TPFGRVTVGLRENTHRLRFLGYNVHVLGTLVFAISAMFAGIAGALQAINIEAANYVVFEA
CCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEC
GISTAVVLNSFIGGVGTFFGPAIGAAAMTFFGHLTSDVTRSWLLYQGLILVLVMMFLPRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVGEAVERFRNPKGTGISLGHALGRLVALLVTAAGTIMIVELVQRFFSSDYKALASAGNW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
PPVTSLGREWLPFAVSTWLIPLALFAAGIALLTIVNRHRAKAKGEA
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TIKQSVVALLVVALLVALPYLVSESMTNAAIQMLIAALFATAFSLLCGQAGMLSFGHAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YFGLGSFAAVHVMNAFGGEGLLPTPLLPLAGAGVGLLSGLVAGWFSTKRTGVYFAMITLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAELLHALAPHLKGTFGGEAGVSSFRMPAWGFDFGSTTEVYYLALAWVVGSILLLFLLTL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TPFGRVTVGLRENTHRLRFLGYNVHVLGTLVFAISAMFAGIAGALQAINIEAANYVVFEA
CCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEC
GISTAVVLNSFIGGVGTFFGPAIGAAAMTFFGHLTSDVTRSWLLYQGLILVLVMMFLPRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LVGEAVERFRNPKGTGISLGHALGRLVALLVTAAGTIMIVELVQRFFSSDYKALASAGNW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
PPVTSLGREWLPFAVSTWLIPLALFAAGIALLTIVNRHRAKAKGEA
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]