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The map label for this gene is phhA

Identifier: 224458591

GI number: 224458591

Start: 2994537

End: 2995355

Strand: Reverse

Name: phhA

Synonym: lpg2647

Alternate gene names: 224458591

Gene position: 2995355-2994537 (Counterclockwise)

Preceding gene: 161723242

Following gene: 52842852

Centisome position: 88.16

GC content: 38.58

Gene sequence:

>819_bases
ATGGAGTTTAGTAGCCGGTATGTCGCACATGTCCCTGATGCTCAGGGTTTAGTCGATTATTCGGCACAAGAAAATAGAAT
TTGGAATATTTTATTTGAGAGGCAACTCAAGTTATTGCCAGGAAGAGCTTGTGATGAATTTCTGTCTGGATTACAGACTT
TAGGACTTAACTCCTCGACTATTCCACAACTTCCAGAAGTAAGTGAGCGATTAAAGGCCAAAACGGGATGGCAAGTAGCG
CCAGTTGCTGCTTTAATTTCAGCCAGGGAATTTTTTGAATTATTAGCAGAAAAATATTTTCCTGCGGCGACTTTTATTCG
AAGTGAAGAAGAATTGGATTATGTTCAAGAACCTGATATTTTTCATGAGCTTTTTGGTCATTGTCCTATGTTAACCGATA
GAGTCTATGCTGAATTTGTCCATGATTACGCATGTAAGGTATTAACTTTTCCTGAACAGGATTGGCCTTTATTGCAAAGA
ATGTTTTGGTTTACTGTAGAGTTTGGATTGATTAAAACGCCTAAAGGGCTTAGAGCATACGGCGGGGGAATTTTATCTTC
TATCAGTGAAACGGTATATTGTGTGGAAAGTGATATTCCTGTGCGAATTTTATTTGATCCAGTGGTGGCTTTTCGAATGC
CTTATCGGATTGACCAGCTACAACCTGTTTATTTCGTTATTGACAGCTATCAAAATTTATATGATTTCGTGCTTTCTGAC
ATGGGTAAATTCATGGATCGTGCGCGAGAGTTAGGTGAATTTCCACCGTATTTTGATGTGGATCCGGATAATCCAAATAT
TCATATAAGGGCTTGTTAA

Upstream 100 bases:

>100_bases
GTAAAAATTCTCGTTGACTTTAATAGGCTGACCCTAAATACAAATAAATATTATTATCCCTGGTTATTTATTTTTGAATG
AGATGAGTGAAGGAGAGATT

Downstream 100 bases:

>100_bases
TTTGTTATTTTGTAAGACAGCTGGACTTGTAGATTAGAGTGACTATGTATTGTAATGATTATCGAGTCTTGTTAACATCG
ACCAACACAGTTTGTTCATT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEFSSRYVAHVPDAQGLVDYSAQENRIWNILFERQLKLLPGRACDEFLSGLQTLGLNSSTIPQLPEVSERLKAKTGWQVA
PVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDIFHELFGHCPMLTDRVYAEFVHDYACKVLTFPEQDWPLLQR
MFWFTVEFGLIKTPKGLRAYGGGILSSISETVYCVESDIPVRILFDPVVAFRMPYRIDQLQPVYFVIDSYQNLYDFVLSD
MGKFMDRARELGEFPPYFDVDPDNPNIHIRAC

Sequences:

>Translated_272_residues
MEFSSRYVAHVPDAQGLVDYSAQENRIWNILFERQLKLLPGRACDEFLSGLQTLGLNSSTIPQLPEVSERLKAKTGWQVA
PVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDIFHELFGHCPMLTDRVYAEFVHDYACKVLTFPEQDWPLLQR
MFWFTVEFGLIKTPKGLRAYGGGILSSISETVYCVESDIPVRILFDPVVAFRMPYRIDQLQPVYFVIDSYQNLYDFVLSD
MGKFMDRARELGEFPPYFDVDPDNPNIHIRAC
>Mature_272_residues
MEFSSRYVAHVPDAQGLVDYSAQENRIWNILFERQLKLLPGRACDEFLSGLQTLGLNSSTIPQLPEVSERLKAKTGWQVA
PVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDIFHELFGHCPMLTDRVYAEFVHDYACKVLTFPEQDWPLLQR
MFWFTVEFGLIKTPKGLRAYGGGILSSISETVYCVESDIPVRILFDPVVAFRMPYRIDQLQPVYFVIDSYQNLYDFVLSD
MGKFMDRARELGEFPPYFDVDPDNPNIHIRAC

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=226, Percent_Identity=38.4955752212389, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI88900505, Length=226, Percent_Identity=38.4955752212389, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI88900501, Length=226, Percent_Identity=38.4955752212389, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4759248, Length=219, Percent_Identity=36.0730593607306, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI4557819, Length=224, Percent_Identity=34.8214285714286, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI31795563, Length=234, Percent_Identity=35.4700854700855, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71980736, Length=242, Percent_Identity=34.297520661157, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17531391, Length=217, Percent_Identity=35.9447004608295, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI115533973, Length=231, Percent_Identity=30.7359307359307, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=231, Percent_Identity=30.7359307359307, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=30.9677419354839, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660393, Length=219, Percent_Identity=37.8995433789954, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI62472054, Length=219, Percent_Identity=37.8995433789954, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17136776, Length=222, Percent_Identity=33.7837837837838, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17136774, Length=222, Percent_Identity=33.7837837837838, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24654994, Length=219, Percent_Identity=32.8767123287671, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 31424; Mature: 31424

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSSRYVAHVPDAQGLVDYSAQENRIWNILFERQLKLLPGRACDEFLSGLQTLGLNSST
CCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
IPQLPEVSERLKAKTGWQVAPVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDI
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCHH
FHELFGHCPMLTDRVYAEFVHDYACKVLTFPEQDWPLLQRMFWFTVEFGLIKTPKGLRAY
HHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCEECCCCHHHH
GGGILSSISETVYCVESDIPVRILFDPVVAFRMPYRIDQLQPVYFVIDSYQNLYDFVLSD
CCHHHHHHHHHEEEECCCCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MGKFMDRARELGEFPPYFDVDPDNPNIHIRAC
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MEFSSRYVAHVPDAQGLVDYSAQENRIWNILFERQLKLLPGRACDEFLSGLQTLGLNSST
CCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
IPQLPEVSERLKAKTGWQVAPVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDI
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCCCHH
FHELFGHCPMLTDRVYAEFVHDYACKVLTFPEQDWPLLQRMFWFTVEFGLIKTPKGLRAY
HHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCEECCCCHHHH
GGGILSSISETVYCVESDIPVRILFDPVVAFRMPYRIDQLQPVYFVIDSYQNLYDFVLSD
CCHHHHHHHHHEEEECCCCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MGKFMDRARELGEFPPYFDVDPDNPNIHIRAC
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]