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The map label for this gene is pyrD

Identifier: 222527449

GI number: 222527449

Start: 5258983

End: 5260074

Strand: Direct

Name: pyrD

Synonym: Chy400_4240

Alternate gene names: 222527449

Gene position: 5258983-5260074 (Clockwise)

Preceding gene: 222527448

Following gene: 222527450

Centisome position: 99.81

GC content: 58.79

Gene sequence:

>1092_bases
TTGAACCGTTCTGAGGCACTGTTCTACCGCTACGGTATACGCCCGATCTTGTTTCGGCTCGGTCGGGGCGACGCCGAGAC
GGCCCATGAACGTACCTTGCATATACTGGCGTTGATCAGTCGCTCACGCCTGTTGTGCAAGACCATCGGGTATCTGACCA
CAATTCGCGATCAACGGCTCCAGCGCACGGTTTGCGGGATACCTTTTCCCAATCCGGTTGGGCTAGCCGCCGGCATGGAT
AAGGATGGTGTGGCAATACCGGCCTGGGCAGCACTGGGCTTTGGCTTCGTCGAGGTTGGCACCGTCACCCATCACCCACA
GCCGGGCAACCCCCGGCCTCGCCTGTTTCGGCTACCAGAGCAGGAAGCGCTGATCAATCGGATGGGGTTCAACAATCAAG
GCGCTGCCAGCCTCGCCAGACGATTGGCCCGCTTGCAGCCGGCACCCATCCCGGTTGGCGTATCAATTGGCAAGTCGAAG
ATTACCCCTCTCGAACAGGCAATTGATGATTACCGGGCGTCGTTTCGTCAGCTCTTTCCGTATGCGGCATACATCGCCAT
CAATGTCAGCTCTCCCAATACTCCTGGCTTGCGCCAGTTACAAGATGCCGACCAGTTGCGTGCGCTGCTGGCAGCTCTGC
AACACGACAATGCGGAATTGGGCCGCACCGACCAGCGCGGCCCCCGGCCACTTCTCGTCAAGATTGCGCCTGATTTGAGC
GATACAGCCATAGAAGAGGTGTTGACCGTCTGCGCCGACCACGGTGTTGCCGGTATCATTGCCACCAATACGACGATCAG
TCGTGAAGGACTGACCGGGGTTGATCCGCGGCTGGCAGCCGAAGCCGGCGGCCTGAGCGGGAGACCACTGATTGCACGTG
CCCTTCACGTGGTACGCCTGATTGCCCGTTTGACAGGCAATCGCCTTCCGATTATTGGGGTCGGAGGCATTCATACACCT
GATGATGGGTTACGTATGTTGGAAGCCGGTGCCAGCCTGATCCAGATCTACACCGGACTGGTCTACTACGGGCCACTGTT
GCCCAGACGGATCAACCGCGCTATCCTTACGCACAGCAAGGTACAGCAATGA

Upstream 100 bases:

>100_bases
GATGACAGTGCAGACCGTAAACGATTACTGAGTCGCATTGACCGTCTGCGTACCACTCGTGATATTGAGCGATTTGCCGA
TGAACTGTCTGAGGTGGGAG

Downstream 100 bases:

>100_bases
ATGGCTTCCTCGGCACAAAAGCTACGTTCGCGCGGGACATCTCGCTGATCGGGAGTATTCTGGTCGCGATTGCTTTCATC
GTTGGTGCCTATCTCGCCGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNRSEALFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTVCGIPFPNPVGLAAGMD
KDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEALINRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSK
ITPLEQAIDDYRASFRQLFPYAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLS
DTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARLTGNRLPIIGVGGIHTP
DDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAILTHSKVQQ

Sequences:

>Translated_363_residues
MNRSEALFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTVCGIPFPNPVGLAAGMD
KDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEALINRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSK
ITPLEQAIDDYRASFRQLFPYAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLS
DTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARLTGNRLPIIGVGGIHTP
DDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAILTHSKVQQ
>Mature_363_residues
MNRSEALFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTVCGIPFPNPVGLAAGMD
KDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEALINRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSK
ITPLEQAIDDYRASFRQLFPYAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLS
DTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARLTGNRLPIIGVGGIHTP
DDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAILTHSKVQQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=366, Percent_Identity=41.8032786885246, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1787177, Length=347, Percent_Identity=43.2276657060519, Blast_Score=258, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17509475, Length=357, Percent_Identity=37.2549019607843, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI281361352, Length=323, Percent_Identity=42.4148606811146, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137316, Length=323, Percent_Identity=42.4148606811146, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_CHLAA (A9WDI1)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001637489.1
- ProteinModelPortal:   A9WDI1
- SMR:   A9WDI1
- GeneID:   5825733
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_3923
- HOGENOM:   HBG351027
- OMA:   ARTNDDQ
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 39418; Mature: 39418

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSEALFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRL
CCCCCEEHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRTVCGIPFPNPVGLAAGMDKDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPE
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCEECCCCCCCCCCCEEECCH
QEALINRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSKITPLEQAIDDYRASFRQLFP
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCC
YAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLS
EEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC
DTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRL
HHHHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHH
IARLTGNRLPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAILTHSK
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VQQ
HCC
>Mature Secondary Structure
MNRSEALFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRL
CCCCCEEHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRTVCGIPFPNPVGLAAGMDKDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPE
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCEECCCCCCCCCCCEEECCH
QEALINRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSKITPLEQAIDDYRASFRQLFP
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCC
YAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLS
EEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC
DTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRL
HHHHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHH
IARLTGNRLPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAILTHSK
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VQQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA