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The map label for this gene is phoP [H]

Identifier: 222527316

GI number: 222527316

Start: 5078576

End: 5079748

Strand: Direct

Name: phoP [H]

Synonym: Chy400_4101

Alternate gene names: 222527316

Gene position: 5078576-5079748 (Clockwise)

Preceding gene: 222527315

Following gene: 222527318

Centisome position: 96.39

GC content: 53.2

Gene sequence:

>1173_bases
ATGAAACCCCATACACTGCTGATCGTTGATGATGACGATACCGTTGCCGAGATGCTCGAACTGGTGCTGCGTGGTGCCGG
TTACGAAGTGCGGCGTGCTGCCAGTGGTGAAGAGGCATTACAGCAGATTTACAAGAATCTACCCGATGCCCTGATCTGCG
ATGTGTTGTTACCCGGCATTGATGGCTACACCCTGTGTAAGCGTGTGCGGCAGCATCCGCTAACCAAAACACTCCCGATT
CTGATGCTTACCGCCCAAGGCGATATTAGTGCCAAGATTGCCGGCTTTGAAGCCGGTGCCAACGATTACCTGGCCAAACC
ATTTGAACCGCAAGAGCTGGTCTACCGGGTTAAGAACATCCTGGCGCGCACGACAATCGAGACCCCGACAACACCGGTAC
AACGCGGAAAGGTGATTACCGTCTTCGGGGCAAAGGGTGGTGTCGGCAAAACAACGATTGCGGTATCGGTGGCGCTGGCG
CTACGCCTGCGTTCACGCCGACGGGTCGTAATTGTTGACGCCGATCTCACCTTCGGTGATGTTGCCGTCCATCTCAACAT
TGCACCCACGCGCAGCATCATCGACATCGTCCGCAGCGGCGACGAGATCGAGCAGGAGATGGTAAAACAGGTTCTGCTTT
CCCATCCATCAGGACTGCAAGCCTTACTCGCTCCGCCACGGCCTGAAGAGGCAGAGCTGGTAAGCGCTGAACATATGACT
CGCATTCTTGATTTACTGGCTGTGAATGCCGATTACGTGGTGGTTGATTGCCAGACCAGCTACGATGATCGCACACTATC
CGTCTTTGATCGCACCGATCACGTCTTGCTGGTCATTACGCCGGAAATTGGCCCACTGAAGAATACCAGTTTATTCCTGA
GCCTGGCTAACCAGTTAGGCATCGATCCGCGGGCGATCAGTATTGTCCTGAACCGATCTAACTCCGGCGTTGGCATTGGT
GTTAATGAAATCGAGCGCGTATTACGCCGTAAGATCAACTATCACGTGATGAGTGGCGGTCAGCCAGTCGTCACAGCGGT
TAATCGTGGCACACCACTAATTCTCGAACAACCCAAACATCCCTTCGTTCAACAGATTCTCTATCTGGCCGATCAGATGA
TGAAACAGCTTGACACTAATCAAAACGTGCAGACAGATACAGTAACCCGGTGA

Upstream 100 bases:

>100_bases
AGTTGCTTTCGGTGTCGATGATTATCTCCTCATTCCACTGGCTGCCGGCGCGTTATCAGCCTTGCTCGATCGCCTGAGTG
CATCAGAGAGGAGCACGTAG

Downstream 100 bases:

>100_bases
TACCACACCGAAACCGATAGCAGACTCTCACTGATTGACACTGGCGCACCTATGATCATGAGGTGCATAAGCGACGTTGA
TACGGCACCGAAACCGATAG

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKPHTLLIVDDDDTVAEMLELVLRGAGYEVRRAASGEEALQQIYKNLPDALICDVLLPGIDGYTLCKRVRQHPLTKTLPI
LMLTAQGDISAKIAGFEAGANDYLAKPFEPQELVYRVKNILARTTIETPTTPVQRGKVITVFGAKGGVGKTTIAVSVALA
LRLRSRRRVVIVDADLTFGDVAVHLNIAPTRSIIDIVRSGDEIEQEMVKQVLLSHPSGLQALLAPPRPEEAELVSAEHMT
RILDLLAVNADYVVVDCQTSYDDRTLSVFDRTDHVLLVITPEIGPLKNTSLFLSLANQLGIDPRAISIVLNRSNSGVGIG
VNEIERVLRRKINYHVMSGGQPVVTAVNRGTPLILEQPKHPFVQQILYLADQMMKQLDTNQNVQTDTVTR

Sequences:

>Translated_390_residues
MKPHTLLIVDDDDTVAEMLELVLRGAGYEVRRAASGEEALQQIYKNLPDALICDVLLPGIDGYTLCKRVRQHPLTKTLPI
LMLTAQGDISAKIAGFEAGANDYLAKPFEPQELVYRVKNILARTTIETPTTPVQRGKVITVFGAKGGVGKTTIAVSVALA
LRLRSRRRVVIVDADLTFGDVAVHLNIAPTRSIIDIVRSGDEIEQEMVKQVLLSHPSGLQALLAPPRPEEAELVSAEHMT
RILDLLAVNADYVVVDCQTSYDDRTLSVFDRTDHVLLVITPEIGPLKNTSLFLSLANQLGIDPRAISIVLNRSNSGVGIG
VNEIERVLRRKINYHVMSGGQPVVTAVNRGTPLILEQPKHPFVQQILYLADQMMKQLDTNQNVQTDTVTR
>Mature_390_residues
MKPHTLLIVDDDDTVAEMLELVLRGAGYEVRRAASGEEALQQIYKNLPDALICDVLLPGIDGYTLCKRVRQHPLTKTLPI
LMLTAQGDISAKIAGFEAGANDYLAKPFEPQELVYRVKNILARTTIETPTTPVQRGKVITVFGAKGGVGKTTIAVSVALA
LRLRSRRRVVIVDADLTFGDVAVHLNIAPTRSIIDIVRSGDEIEQEMVKQVLLSHPSGLQALLAPPRPEEAELVSAEHMT
RILDLLAVNADYVVVDCQTSYDDRTLSVFDRTDHVLLVITPEIGPLKNTSLFLSLANQLGIDPRAISIVLNRSNSGVGIG
VNEIERVLRRKINYHVMSGGQPVVTAVNRGTPLILEQPKHPFVQQILYLADQMMKQLDTNQNVQTDTVTR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=146, Percent_Identity=35.6164383561644, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=35, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790860, Length=136, Percent_Identity=36.7647058823529, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788394, Length=119, Percent_Identity=37.8151260504202, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=35.7723577235772, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790437, Length=137, Percent_Identity=35.036496350365, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=38.135593220339, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790863, Length=122, Percent_Identity=35.2459016393443, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787375, Length=120, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786911, Length=137, Percent_Identity=33.5766423357664, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787229, Length=152, Percent_Identity=32.2368421052632, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788550, Length=163, Percent_Identity=29.4478527607362, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082012, Length=113, Percent_Identity=32.7433628318584, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790552, Length=118, Percent_Identity=36.4406779661017, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367329, Length=121, Percent_Identity=37.1900826446281, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789402, Length=134, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 42852; Mature: 42852

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPHTLLIVDDDDTVAEMLELVLRGAGYEVRRAASGEEALQQIYKNLPDALICDVLLPGI
CCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCC
DGYTLCKRVRQHPLTKTLPILMLTAQGDISAKIAGFEAGANDYLAKPFEPQELVYRVKNI
CHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LARTTIETPTTPVQRGKVITVFGAKGGVGKTTIAVSVALALRLRSRRRVVIVDADLTFGD
HHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
VAVHLNIAPTRSIIDIVRSGDEIEQEMVKQVLLSHPSGLQALLAPPRPEEAELVSAEHMT
EEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
RILDLLAVNADYVVVDCQTSYDDRTLSVFDRTDHVLLVITPEIGPLKNTSLFLSLANQLG
HHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHC
IDPRAISIVLNRSNSGVGIGVNEIERVLRRKINYHVMSGGQPVVTAVNRGTPLILEQPKH
CCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEECCCC
PFVQQILYLADQMMKQLDTNQNVQTDTVTR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKPHTLLIVDDDDTVAEMLELVLRGAGYEVRRAASGEEALQQIYKNLPDALICDVLLPGI
CCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCC
DGYTLCKRVRQHPLTKTLPILMLTAQGDISAKIAGFEAGANDYLAKPFEPQELVYRVKNI
CHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LARTTIETPTTPVQRGKVITVFGAKGGVGKTTIAVSVALALRLRSRRRVVIVDADLTFGD
HHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
VAVHLNIAPTRSIIDIVRSGDEIEQEMVKQVLLSHPSGLQALLAPPRPEEAELVSAEHMT
EEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
RILDLLAVNADYVVVDCQTSYDDRTLSVFDRTDHVLLVITPEIGPLKNTSLFLSLANQLG
HHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHC
IDPRAISIVLNRSNSGVGIGVNEIERVLRRKINYHVMSGGQPVVTAVNRGTPLILEQPKH
CCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEECCCC
PFVQQILYLADQMMKQLDTNQNVQTDTVTR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]